Results 31 to 40 of about 21,571 (256)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Design and analysis of a 32 × 5 Gbps passive optical network employing FSO based protection at the distribution level☆

Alexandria Engineering Journal, 2020
A cost efficient and reliable single mode fiber and free space optics based hybrid 32×5Gbps ultra dense wavelength division multiplexed-passive optical network architecture employing optical comb and polarization multiplexing is proposed.
Jawad Mirza, Waqas A. Imtiaz, Abdulah Jeza Aljohani, Ahmad Atieh, Salman Ghafoor   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Genetic-Algorithm-Driven Intelligent Spatiotemporal Mode-Locking in All-Fiber Laser with Hysteresis

Photonics
We demonstrate a robust intelligent spatiotemporal mode-locked fiber laser with large modal dispersion, based on the nonlinear polarization rotation mechanism and an electric polarization controller (EPC).
Yangbing Lin, Yongguo Zheng, Xinhai Zhang   +2 more
doaj   +1 more source

Vector Nature of Dissipative-Soliton-Resonance Pulses in Fiber Lasers Mode-Locked by Nonlinear Polarization Rotation Technique

IEEE Photonics Journal, 2019
The vector nature of dissipative-soliton-resonance (DSR) pulses is numerically investigated in an all-normal-dispersion Yb-doped fiber laser mode-locked by the nonlinear polarization rotation technique.
Wenxiong Du, Heping Li, Junwen Li, Zhuang Wang, Pinghe Wang, Zhiyao Zhang, Yong Liu   +6 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

14.5 GHz passive harmonic mode-locking in a dispersion compensated Tm-doped fiber laser

Scientific Reports, 2017
We demonstrate a high repetition rate passive harmonic mode-locking (HML) based on nonlinear polarization evolution (NPE) technique in a Tm-doped ring fiber laser cavity.
Yazhou Wang, Jianfeng Li, Kundong Mo, Yanyan Wang, Fei Liu, Yong Liu   +5 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Analysis of signal processing techniques for optical 112 Gb/s DP-QPSK receivers with experimental data

Journal of Microwaves, Optoelectronics and Electromagnetic Applications
This paper evaluates several signal processing techniques for optical dual-polarization quadrature phase-shift keying (DP-QPSK) coherent receivers, using offline post-processing of experimental data.
Thiago F. Portela, Diego V. Souto, Valery N. Rozental, Hugo B. Ferreira, Darli A. A. Mello, Helmut Griesser   +5 more
doaj   +1 more source