Results 51 to 60 of about 62,112 (266)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Journal of Materials Research and Technology, 2022 The paper investigates the effect of tool eccentricity on the strain rate and microtextures produced in rapid-quenched AA6061 friction stir welds. Thermocouples are embedded in the tool and the thermal cycle are recorded via a data acquisition system ...
Luqman Hakim Ahmad Shah +4 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Геодинамика и тектонофизика, 2015 Drifting and submeridional compression of the continental and oceanic lithosphere, both with the northward vector (Figure 1) are revealed at the background of various directions of horizontal displacement combined with deformations of horizontal ...
Mikhail A. Goncharov +2 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Materials Research, 2009 Experiments have been conducted to study the strain induced transformation from austenite to martensite in a metastable AISI 301LN austenitic stainless steel, deformed by uniaxial tension applied along rolling direction.
Hamilton Ferreira Gomes de Abreu +3 more
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Omega transition accompanied by mechanically-induced twinned martensite
Materials Research Express, 2020 We present here an analysis on omega transition process during martensitic transformation. Martensitic transformation occurred during deformation at room temperature, avoiding the influence of auto-tempering on metastable omega phase.
P J Du, Y J Li, R D K Misra, D Wu
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Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
MATEC Web of Conferences, 2016 Mathematical model for a polycrystalline specimen and EBSD experiment is proposed. As the measurement parameters, the scanning step and the threshold disorientation angle are considered.
Antonova Anastasia O. +2 more
doaj +1 more source