Results 61 to 70 of about 61,709 (266)

Practical applications of the method of generalized pole figures [PDF]

IOP Conference Series: Materials Science and Engineering, 2015
Several actual practical applications of the new X-ray method of generalized pole figures are considered. Among them there are determination of c- and a-dislocation densities in shell tubes from Zr-1%Nb alloy, analysis of strain hardening at opposite sides of shell tubes from ferrritic-martensitic steel with oxide disperse strengthening particles for ...
Yu Perlovich, M Isaenkova, V Fesenko, O Krymskaya, P Dobrokhotov   +4 more
openaire   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Study of EBSD Experiment Parameters Influence on Computation of Polycrystalline Pole Figures and Orientation Distribution Function

MATEC Web of Conferences, 2016
Mathematical model for a polycrystalline specimen and EBSD experiment is proposed. As the measurement parameters, the scanning step and the threshold disorientation angle are considered.
Antonova Anastasia O., Dzhumaev Pavel S., Savyolova Tatyana I.   +2 more
doaj   +1 more source

Piezoelectric Pole Figure of a Vein Quartz Sample [PDF]

Texture, Stress, and Microstructure, 1988
Longitudinal piezoelectric coefficients have been measured on cubic samples and from 150 different orientations on a spherical sample of coarse‐grained vein quartz. The results are consistent with the presence of a piezoelectric fabric. The piezoelectric pole figure of the studied spherical sample demonstrates three distinct patterns of alternatively ...
M. M. Ghomshei, B. B. Narod, T. L. Templeton, A. S. Arrott, R. D. Russell   +4 more
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Crystal plastic deformation and texture evolution mechanism of ZK61 magnesium alloy hot-rolled plate

Cailiao gongcheng
The crystal internal stress and texture evolution of six-pass hot rolled ZK61 magnesium alloy plate are studied by means of combining macroscopic finite element simulation and microscopic crystal plasticity analysis.
WEI Hongzhe, CHEN Ming, WANG Haolei, LIU Qingjie, HU Xiaodong, ZHAO Hongyang   +5 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source