Results 81 to 90 of about 424,658 (301)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Spectral Analysis of Gluonic Pole Matrix Elements

, 2008
We use a spectator framework to investigate the spectral properties of quark-quark-gluon correlators and use this to study gluonic pole matrix elements. Such matrix elements appear in principle both for distribution functions such as the Sivers function ...
Gamberg, L. P., Mukherjee, A., Mulders, P. J.   +2 more
core   +1 more source

Computer-aided pole figure construction

Computers & Geosciences, 1991
Abstract A microcomputer application has been designed to assist in the construction of pole figures using a digital universal microscope stage. The software monitors the stage orientation and switch settings in real time. The trend and plunge of the microscope axis is displayed on an equal area (Schmidt) stereonet in a user-defined reference frame ...
openaire   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crystal plastic deformation and texture evolution mechanism of ZK61 magnesium alloy hot-rolled plate

Cailiao gongcheng
The crystal internal stress and texture evolution of six-pass hot rolled ZK61 magnesium alloy plate are studied by means of combining macroscopic finite element simulation and microscopic crystal plasticity analysis.
WEI Hongzhe, CHEN Ming, WANG Haolei, LIU Qingjie, HU Xiaodong, ZHAO Hongyang   +5 more
doaj   +1 more source

Large Rapidity Gaps in PP Collisions

, 1993
The survival probability of large rapidity gaps in pp collisions is calculated for several different eikonal models of the Gaussian form. Results obtained for models based on partonic interactions are quite similar. The Regge-pole model predicts a higher
Aurenche, Bjorken, Bloch, Bloch, Block, Chjehime, Chou, Chou, Cudell, Dokshitzer, Donnachie, E. Gotsman, E.M. Levin, Engel, Kuraev, Landshoff, Lipatov, U. Maor   +17 more
core   +2 more sources

Quark model description of quasi-elastic pion knockout from the proton at JLAB [PDF]

, 2006
The interference term between s- and t-pole contributions to the p(e,e' pi+)n cross section is evaluated on the basis of the constituent quark model. It is shown that the contribution of baryon s-poles can be modeled by a nonlocal extension of the Kroll ...
Ackleh, Actor, Amand Faessler, Beise, Cano, Cardarelli, D. Fedorov, Faessler, Gross, Guidal, Gutbrod, I.T. Obukhovsky, Koch, Kroll, Le Yaouanc, Maris, Melnitchouk, Neudatchin, Nikolaev, Obukhovsky, Speth, Speth, Speth, Th. Gutsche, V.E. Lyubovitskij, Vanderhaeghen, Volmer, Yudin   +27 more
core   +3 more sources

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Deposition of biaxially aligned YSZ layers by dual unbalanced magnetron sputtering [PDF]

, 2004
Biaxially aligned YSZ (Yttria Stabilised Zirconia) layers were deposited by unbalanced magnetron sputtering, in a dual magnetron geometry. The unbalanced magnetrons were mounted in such a way that the angle between the target- and substrate normal was 55°
De Gryse, Roger, De Winter, Griet, Denul, Jurgen, Mahieu, Stijn   +3 more
core