Results 51 to 60 of about 8,059,514 (302)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Proposing policy tools for developing production and demand of knowledge-based products using the concept of policy mix and system failures [PDF]

بهبود مدیریت, 2019
Undertaking innovation in developing countries and transition towards knowledge-based economy is difficult without government intervention; necessity of balance between supply- and demand-side policies, the need for holistic view and the interconnections
Mohammad Reza Attarpour, Kiarash Fartash, Mehdi Elyasi, Ali Asghar Sadabadai   +3 more
doaj  

Positioning public procurement as a procedural tool for innovation: an empirical study

Policy & Society, 2021
Procurement has received scholarly attention as a valuable policy tool to reach desired outcomes in society, such as innovation. While interest has grown in analyzing the impact of the ‘substantive’ function of procurement (purchasing of goods and ...
Mehmet Akif Demircioglu, Roberto Vivona
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

The Tools of Policy Formulation:Actors, Capacities, Venues and Effects [PDF]

, 2015
Policy analysts are accustomed to thinking in terms of tools and instruments. Yet an authoritative examination of the tools which have been developed to formulate new policies is missing.
Turnpenny, John R., Howlett, Michael, Turnpenny, John, Migone, Andrea, Andrew J. Jordan, Rayner, Timothy, John R. Turnpenny, Jordan, Andrew J., Jordan, Andrew, Wellstead, Adam, Benson, David, Evans, Bryan, Tan, Seck L., Adam Wellstead, Bryan Evans, Michael Howlett, Seck L. Tan, Andrea Migone   +17 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Metagovernance of migration policy in the Asia Pacific region: an analysis of policy tools

Policy & Society, 2021
This article considers how nation states steer transnational forums by examining how the Australian government has ‘metagoverned’ the Bali Process on People Smuggling, Trafficking in Persons and Related Transnational Crime, a multilateral forum with 50 ...
Paul Fawcett
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Relationship between the Changes in Policy Tools of the Central Government and the Local Fiscal Structure: Focused on the Changes in the Transaction Taxes [PDF]

Journal of Contemporary Eastern Asia, 2017
This study aimed to determine the changes in the local fiscal structure brought about by the change in the transaction tax, including the acquisition tax, by the central government. The review of the analysis results proved the following.
Miae Lee, Inseok Seo
doaj   +1 more source