Results 101 to 110 of about 799,584 (305)
Multidecadal (1960–2011) shoreline changes in Isbjørnhamna (Hornsund, Svalbard) [PDF]
, 2015 A section of a gravel-dominated coast in Isbjørnhamna (Hornsund, Svalbard) was analysed to calculate the rate of shoreline changes and explain processes controlling coastal zone development over last 50 years.
Błaszczyk, Małgorzata +11 more
core +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Competitiveness of the Polish Food Sector after the accession to the European Union [PDF]
The paper focuses on the competitiveness as a driving force of market economy. The analyses of the results of foreign trade in agricultural and food products confirm that Polish agro-food sector is well prepared for operation on the Common European ...
Szczegolska, Monika, Szczepaniak, Iwona
core
Critical Approaches to Discourse Analysis across Disciplines, 2015 Embedded in the framework of positive discourse analysis (PDA), this article investigates the discourse of gender dissidents using the example of Latvian and Polish LGBTQ and feminist blogs.
Joanna Chojnicka
doaj
LinguisticsOf similative origin, Polish jakoby derives from the connective jako ‘how, that’ univerbated with the irrealis enclitic by. From the earliest attested stages (late 14th century) into the 17th century, jakoby was used as a comparison marker and as a ...
Wiemer Björn
doaj +1 more source