Results 41 to 50 of about 345,897 (268)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Classification of Turkic (and via Turkic) Loanwords in the Polish Vocabulary

open access: yesTürkiyat Mecmuası
Interlingual borrowing is the process by which a language borrows words or structures from another language. This process occurs as a result of various interactions such as cultural, commercial, technological, literary, scientific, and historical.
Emrah Gaznevi
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Polish historical book as a phenomenon of intellectual culture of the Renaissance

open access: yesБиблиосфера, 2013
The article is dedicated to the problem of evolution of Polish history book in the late Middle Ages and Renaissance. The author studied manuscripts and old-printed books of most famous Polish historians – Jan Długosz, Mathias Mechovius, Martin Kromer ...
D. V. Karnaukhov
doaj  

Repliki dialogowe informujące o emocjach z pola zdziwienia (na materiale współczesnych utworów prozatorskich napisanych w języku polskim, rosyjskim i angielskim)

open access: yesStudia Linguistica
The aim of the article is to analyze dialogue replicas communicating emotions from the lexical-semantic field of surprise, retrieved from contemporary prose works written in Polish, Russian and English.
Daniel Dzienisiewicz
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Reflexive Verbs In Polish: On The Inclusion Of Slavic Language Into A Model Based On Germanic Languages

open access: yesACC Journal
This article examines whether and to what extent Polish can be integrated into a model based on Germanic languages. The model deals with the categorization and use of reflexive verbs and pronouns.
Zuchewicz Karolina, Czarnetzki Lilli
doaj   +1 more source

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