Results 51 to 60 of about 345,897 (268)

Challenges of translating C. S. Lewis’s “The Problem of Pain” into Polish and Spanish by professional translators – comparative and evaluative perspectives [PDF]

Studia Translatorica
The article discusses diverse translation challenges which translators may be confronted with while working on target-language renditions of C. S. Lewis’s “The Problem of Pain”. To present his thoughts and theses, this famous British writer, philosopher,
Adam Palka
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Geschlossen, lang oder gespannt? Die Beschreibung der Artikulation niederländischer Vokale aus einer polykonfrontativen (und didaktischen) Perspektive [PDF]

Linguistische Treffen in Wrocław
By analyzing the descriptions of Dutch vowels in the selected literature in four languages (Dutch, Polish, German and English), this paper addresses issues at the intersection of terminology and phonetics, while also placing them in the context of ...
Zuzanna Czerwonka-Wajda
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Türkiye-Polonya İlişkilerinin Tesisinde Başlıca Dış Dinamiklerin Fonksiyonu

Journal of Universal History Studies, 2019
Dünya tarihinin iki kadim milleti olan Polonyalılar/Lehler ve Türklerin ikili ilişkilerinde hem Osmanlı Devleti hem de Türkiye Cumhuriyeti’nin kuruluş döneminde temel dış dinamiklerden biri Çarlık Rusya/Sovyet Rusya’nın izlediği dış politika olmuştur. 20.
Hadiye Yılmaz Odabaşı
doaj   +1 more source

Sprachliche Etikette im polnisch-deutschen Vergleich lexikographisch erfasst

Linguistische Treffen in Wrocław, 2020
Höflichkeit ist ein Phänomen, das neulich immer häufiger auch sprachlich untersucht wird. Es handelt sich dabei um sprachliche Formen und Formeln, die in bestimmten Kommunikationssituationen ein-gesetzt werden können. Dabei spielt die sog.
Joanna Szczęk
doaj   +1 more source