Results 31 to 40 of about 6,187,809 (272)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Prosodic constituents in the representation of consonantal sequences in Polish [PDF]

open access: yes, 2013
The aim of this paper is to show what role prosodic constituents, especially the foot and the prosodic word play in Polish phonology. The focus is placed on their function in the representation of extrasyllabic consonants in word-initial, word-medial ...
Rochoń, Marzena
core  

Siedemnastowieczna polszczyzna kijowska w panegirykach Stefana Jaworskiego

open access: yesForum Lingwistyczne, 2019
The article discusses a regional variety of Polish spoken in Kiyv preserved in the Polish-Latin panegyrics composed by Stefan Jaworski (1656(8)–1722) to venerate Warłam Jasiński.
Jolanta Klimek-Grądzka
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Урбанонимическая омореферентность в устной русской речи

open access: yesStudia Rossica Posnaniensia, 2018
The idea of the Polish scientist, Jerzy Kaliszan, regarding the omo-reference of the facts of word-formation and form-formation in the Russian language is developing on the basis of Russian urbanonyms; it has been established that the formation of ...
Антонина Щербак
doaj   +1 more source

Problemy opisu staropolskiej derywacji czasownikowej

open access: yesLingVaria, 2020
Problems in the description of old polish verbal derivation The article discusses the problems associated with the description of verbal derivation in the earliest period of the Polish language.
Aleksandra Janowska
doaj   +1 more source

Polish Derivational Nests with Nouns Delineating the Seasons of the Year – a Comparison with the Russian Language

open access: yesZeszyty Cyrylo-Metodiańskie, 2023
The article discusses derivational nests of Polish nouns ‘wiosna’, ‘lato’, ‘jesień’, ‘zima’ in comparison with their Russian equivalents ‘весна’, ‘лето’, ‘осень’, ‘зима’.
Anna Stasienko
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

open access: yesFEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

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