Results 41 to 50 of about 105,591 (295)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Experimentation to Reduce Friction from Novel Abrasive Tape Polishing Method [PDF]

, 2010
The aim is to develop and improve a finishing process that allows reduced CO2 emissions, through reduced use of carbon-based fuels, achieving improvement in fuel consumption.
Chen, Xun, Blunt, Liam, Wilkinson, Adam
core   +3 more sources

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Pulsed Laser Micro Polishing: Surface Prediction Model [PDF]

, 2011
This project is focused on developing physics-based models to predict the outcome of pulsed laser micro polishing (PL P). Perry et al. have modeled PL P as oscillations of capillary waves with damping resulting from the forces of surface tension and ...
Li, Xiaochun, Ma, Chao, Duffie, Neil A., Pfefferkorn, Frank E., Vadali, Madhu   +4 more
core  

A New Environmentally Friendly Chemical Mechanical Polishing Method Applied for Surface Finishing Ti-6Al-4V Alloy [PDF]

, 2023
A new eco-friendly slurry has been developed for the chemical mechanical polishing process with a solution of malic acid, deionized water, and an oxidizing agent hydrogen peroxide (H2O2).
Tung, Nguyen Tien, Hai, Ha Thanh, Nguyen Minh Quang, Ha Thanh Hai, Mai, Nguyen Trong, Nguyen Ngoc Quan, Nguyen Trong Mai, Quang, Nguyen Minh, Le Thi Phuong Thanh, Tran Ngoc Tan, Nguyen Tien Tung, Nguyen Duy Trinh, Thanh, Le Thi Phuong, Trinh, Nguyen Duy, Quan, Nguyen Ngoc, Tan, Tran Ngoc   +15 more
core   +1 more source

Effect of optical processing on the surface structure of paratellurite single crystals

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов, 2023
The effect of optical treatment of the surfaces of a paratellurite single crystal corresponding to the (100), (110), and (001) crystallographic planes was studied.
S.V. Molchanov, S.A. Tretyakov, A.M. Ivanov, I.A. Kaplunov   +3 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Class I Gap-formation in Highly-viscous Glass-ionomer Restorations: Delayed vs Immediate Polishing [PDF]

, 2008
This in vitro study evaluated the effects of delayed versus immediate polishing to permit maturation of interfacial gap-formation around highly viscous conventional glass-ionomer cement (HV-GIC) in Class I restorations, together with determining the ...
Maruo, Yukinori, Suzuki, Kazuomi, Watts, David C, Nishgawa, Goro, Watts, David C.; id_orcid, Irie, Masao   +5 more
core   +1 more source