Results 21 to 30 of about 130,543 (268)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Human Security and the Special Autonomy

Bestuurskunde, 2022
Issues of human rights violations, poverty, unemployment, low HDI, low access to education, and poor health are the most important parts of the concept of human security introduced by the UNDP report 1994. These issues have not been adequately addressed
Hendy Setiawan, Khalimatus Sa’diyah
doaj   +1 more source

On becoming political: the political in subjectivity [PDF]

Subjectivity, 2017
This article explores mundane political agency. We introduce the notion of the political ordinary as agency based on the capacity of human beings to carry out acts that are undetermined and unexpected, and thus capable of challenging, opposing, negotiating, maintaining, and readjusting prevailing conditions.
Häkli, Jouni, Kallio, Kirsi Pauliina
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

An Overview of Post-structuralism in Comparative Analysis of Pakistan and Türkiye in Managing Refugee Crisis

Journal of Research in Social Sciences, 2022
Pakistan and Türkiye host millions of registered Afghan and Syrian refugee respectively and provide them with humanitarian aid. This study highlights the picture demonstrated to the world, made by Türkiye and Pakistan to address refugee crises. In Middle
Khushboo Fatima, Dr. Amna Mahmood, Muneeba Shahid   +2 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Faith-Based and Community Organizations as Human Security Actors: Bridging Governance Gaps in Kwara North

Bulletin of "Carol I" National Defense University
This study investigates the role of faith-based and community organizations in advancing human security through poverty alleviation initiatives in Kwara North, Nigeria. Situated within the broader discourse on non-state actors and governance, it examines
Abdulrauf AMBALI, Alabi ABDULLAHI, Moshood Olayinka SALAHU SALAHU, Ibrahim A. ADEYANJU   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source