Results 31 to 40 of about 130,543 (268)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

STRUCTURE AND FORMS OF THE ARGUMENT ANALYSIS IN THE MAKING OF THE CITY GOVERNMENT BUDGET POLICY IN MAKASSAR

open access: yesJPP (Jurnal Politik Profetik), 2018
This paper aims to analysis the dynamics related to the policy making process related to its structure and forms of argument analysis. Based on the research was conducted in Makassar, within the framework of policy system, this research describes the ...
Muhammad Saad, Sukri Tamma
doaj   +1 more source

Post-election survey data: Local democracy and the 2018 local elections in the Czech Republic

open access: yesData in Brief, 2021
This article presents unique survey data focused on local democracy, political attitudes and political participation. The main aim of the research was to understand the relationships between political values, political participation, political knowledge ...
Pavel Šaradín   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Introducing the Archive of Interwar Europe Election Data & Assemblies (AIEEDA)

open access: yesScientific Data
We describe the Archive of Interwar Europe Election Data and Assemblies (AIEEDA), a new multi-level dataset of parliamentary elections in interwar Europe (1919-1939).
Lea Kaftan   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Security Expenditures and Fiscal Strain: The Impact of the Farmer-Herder Conflict on Public Finance in Northern Nigeria (2015–2024)

open access: yesBulletin of "Carol I" National Defense University
Nigeria has been entrapped in a cycle of insecurity which has not only affected the lives and properties of its citizens, but as had a colossal effect on the macro-economy of the state.
Ibrahim O. SALAWU   +3 more
doaj   +1 more source

Aristotle’s Politics: Ethical Politics or Political Realism?

open access: yes, 2017
Much of the scholarly literature provides significant support for the ethical foundation of Aristotelian political science. Still, it cannot be said that there is a smooth relationship between Aristotle’s ethical thinking and his theory of politics in the Politics.
openaire   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

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