Results 31 to 40 of about 134,392 (268)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Introducing the Archive of Interwar Europe Election Data & Assemblies (AIEEDA)

Scientific Data
We describe the Archive of Interwar Europe Election Data and Assemblies (AIEEDA), a new multi-level dataset of parliamentary elections in interwar Europe (1919-1939).
Lea Kaftan, Bruno Della Sala, Olga Jerjomina, Stefan Stojkovic, Edoardo Alberto Viganò, Nils-Christian Bormann   +5 more
doaj   +1 more source

STRUCTURE AND FORMS OF THE ARGUMENT ANALYSIS IN THE MAKING OF THE CITY GOVERNMENT BUDGET POLICY IN MAKASSAR

JPP (Jurnal Politik Profetik), 2018
This paper aims to analysis the dynamics related to the policy making process related to its structure and forms of argument analysis. Based on the research was conducted in Makassar, within the framework of policy system, this research describes the ...
Muhammad Saad, Sukri Tamma
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Security Expenditures and Fiscal Strain: The Impact of the Farmer-Herder Conflict on Public Finance in Northern Nigeria (2015–2024)

Bulletin of "Carol I" National Defense University
Nigeria has been entrapped in a cycle of insecurity which has not only affected the lives and properties of its citizens, but as had a colossal effect on the macro-economy of the state.
Ibrahim O. SALAWU, Moshood Olayinka SALAHU, Emmanuel Oyewole LAMBE, Hassan Seyid ISHOLA   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Patron-client relationship in the Rohingya camps: recent trends and impact on refugee governance

Journal of International Humanitarian Action
Bangladesh’s rapidly increasing population is putting immense pressure on its resources. Additionally, the country bears the responsibility of providing shelter and protection to millions of Rohingya refugees.
Nurul Huda Sakib, Nusrat Mahmood, Tasbir Ul Islam   +2 more
doaj   +1 more source

Aristotle’s Politics: Ethical Politics or Political Realism?

, 2017
Much of the scholarly literature provides significant support for the ethical foundation of Aristotelian political science. Still, it cannot be said that there is a smooth relationship between Aristotle’s ethical thinking and his theory of politics in the Politics.
openaire   +3 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source