Results 61 to 70 of about 6,751,333 (339)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

On the belief that beliefs should change according to evidence: Implications for conspiratorial, moral, paranormal, political, religious, and science beliefs [PDF]

, 2020
Gordon Pennycook, James Allan Cheyne, Derek J. Koehler, Jonathan A. Fugelsang   +3 more
openalex   +1 more source

Building Mistrust: ‘Minha Casa Minha Vida’ and its Political Effects in Rio de Janeiro [PDF]

, 2021
Silvia Stefani
openalex   +1 more source

Card games are effective tools to enhance foundation year health and safety inductions

FEBS Open Bio, EarlyView.
A series of three card games was developed to actively deliver health and safety education to foundation year students. Most students reported positive responses regarding their enjoyment (89.9 %) and learning (74.7 %) from all games evaluated. Data revealed significant improvements in health and safety knowledge (P < 0.0001).
Rumana Rafiq, Holly Matthews, Daniya Abedalreza, Faten Yahya, Matthew Allan Jones   +4 more
wiley   +1 more source

STRUCTURE AND FORMS OF THE ARGUMENT ANALYSIS IN THE MAKING OF THE CITY GOVERNMENT BUDGET POLICY IN MAKASSAR

JPP (Jurnal Politik Profetik), 2018
This paper aims to analysis the dynamics related to the policy making process related to its structure and forms of argument analysis. Based on the research was conducted in Makassar, within the framework of policy system, this research describes the ...
Muhammad Saad, Sukri Tamma
doaj   +1 more source

Integrating biodiversity: a longitudinal and cross-sectoral analysis of Swiss politics [PDF]

, 2022
Ueli Reber, Manuel Fischer, Karin Ingold, Felix Kienast, Anna M. Hersperger, Rolf Grütter, Robin Benz   +6 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Introducing the Archive of Interwar Europe Election Data & Assemblies (AIEEDA)

Scientific Data
We describe the Archive of Interwar Europe Election Data and Assemblies (AIEEDA), a new multi-level dataset of parliamentary elections in interwar Europe (1919-1939).
Lea Kaftan, Bruno Della Sala, Olga Jerjomina, Stefan Stojkovic, Edoardo Alberto Viganò, Nils-Christian Bormann   +5 more
doaj   +1 more source

Conceptualising backlash politics: Introduction to a special issue on backlash politics in comparison [PDF]

, 2020
Karen J. Alter, Michael Zürn
openalex   +1 more source