Results 61 to 70 of about 107,391 (310)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Rabelais's contempt for fortune: Pantagruelism, politics, and philosophy Politics, literature, & film./ Timothy Haglund.

open access: yes, 2019
Includes bibliographical references and index.Francois Rabelais wrote Gargantua and Pantagruel at the height of the Renaissance, when top-caliber thinkers aimed to unite the best of freshly rediscovered ancient Greco-Roman theory and practice and ...
Haglund Timothy
core  

Why moralize upon it?: democratic education through American literature and film Politics, literature, & film./ Brian Danoff.

open access: yes, 2020
Danoff argues that novels and films with an ambiguous, nuanced, and tragic outlook help teach citizen-readers how to think through the moral complexities of political issues on which they must render judgment.
Danoff Brian
core  

The Art of Writing Utopian and Dystopian Novels in the World Literature

open access: yes, 2022
This article is devoted to the history of the creation of utopian and dystopian novels, which have a special place and form in modern world literature, and their current development.
Mustafayevna, Begmatova Sokhiba
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Age of anxiety: meaning, identity, and politics in 21st century film and literature Politics, literature, & film./ Anthony M. Wachs and Jon D. Schaff.

open access: yes, 2019
Includes bibliographical references and index."Age of Anxiety: Meaning, Identity, and Politics in 21st Century Film and Literature applies historical and contemporary political and rhetorical theory to current popular culture to discuss the problem of ...
Wachs Anthony M.,, Schaff Jon D.,
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Literature as a defining trait of the human umwelt: From and beyond Heidegger

open access: yesSign Systems Studies, 2016
Writers and readers of literature are, among other things, biological en tities that evolve under particular political (geographical/historical) conditions.
Pierre-Louis Patoine, Jonathan Hope
doaj   +1 more source

Public value, politics and public management: a literature review

open access: yes, 2006
This paper summarises the findings of the literature review on politics and public management and sets out the theoretical background that underpins the concept of Public Value.
Lekhi, R., Horner, L., Blaug, R.
core  

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