Polo like kinase 2 tumour suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancer [PDF]
, 2012 The polo-like kinase PLK2 has recently been identified as a potential theranostic marker in the management of chemotherapy sensitive cancers. The methylation status of the PLK2 CpG island varies with sensitivity to paclitaxel and platinum in ovarian ...
Mcneish, I. +6 more
core +8 more sources
Digital range of motion analysis is sensitive to subjective steps in joint model construction. [PDF]
J AnatA systematic sensitivity analysis of a six degree‐of‐freedom range of motion (ROM) analysis workflow was conducted to evaluate how variation in the subjective steps of the reference pose assembly affects the determined viable poses in the ankle and tarsometatarsophalangeal III joints of Guinea fowl (Numida meleagris).
Lowes RJ +4 more
europepmc +2 more sources
Acta Ortopédica Brasileira, 2011 OBJETIVO: avaliar a correlação entre a presença de uma faceta medial do semilunar e a incidência de lesões ligamentares e artrose do pólo proximal do hamato. MÉTODOS: Avaliação artroscópica e dissecação dos punhos foram efetuados em cadáveres. RESULTADOS:
Edgard de Novaes França Bisneto +4 more
doaj +1 more source
Plk1 promotes renal tubulointerstitial fibrosis by targeting autophagy/lysosome axis
Cell Death and Disease, 2023 The prevalence of chronic kidney disease (CKD) has been increasing over the past decades. However, no effective therapies are available for delaying or curing CKD.
Yang Du +12 more
doaj +1 more source
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication [PDF]
, 2015 Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and cytokinesis; PLK4 is a master regulator of centriole duplication.
Timm Maier +15 more
core +1 more source
Comparison of two anaerobic water polo-specific tests with the Wingate test [PDF]
, 2009 The purpose of the current study was to compare 2 water polo–specific tests—the 14 3 25-m swims (SWIM) and the 30-second crossbar jumps (30CJ)—with a laboratory-based test of anaerobic power, the Wingate Anaerobic Test (WAnT).
Marrin, K. +6 more
core +1 more source
Revista Iberoamericana de Cirugía de la Mano, 2004 Se presenta la experiencia obtenida con injerto óseo vascularizado dependiente de la arteria del cuarto compartimento extensor de radio distal en siete pacientes con pseudoartrosis de escafoides.
M. Molina Martos +4 more
doaj +1 more source
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis [PDF]
, 2003 We have investigated the function of mitotic kinesin-like protein (MKlp) 2, a kinesin localized to the central spindle, and demonstrate that its depletion results in a failure of cleavage furrow ingression and cytokinesis, and disrupts localization of ...
Mayer, Thomas U. +20 more
core +1 more source
Problemática y tratamiento actual de la seudoartrosis de escafoides
Revista Iberoamericana de Cirugía de la Mano, 2007 La fractura de escafoides es la más frecuente del carpo y es inherentemente inestable, por lo que aún con tratamiento precoz puede evolucionar hacia la seudoartrosis hasta en un 55% de los casos.
A. Luis Calero +3 more
doaj +1 more source
On the regulation of centriole duplication in human cells : exploring the interactions of polo-like kinase 4 with the centrosomal proteins Cep192 and STIL [PDF]
, 2015 Centrioles duplicate once in each cell cycle to give rise to two centrosomes that form the spindle poles during mitosis. Aberrant centriole duplication can result in the formation of supernumerary centrosomes, leading to incorrect spindle assembly and ...
Gabryjonczyk, Anna-Maria
core +1 more source