Results 191 to 200 of about 22,356 (221)

Poloxamer Thermogel Systems as Medium for Crystallization

Pharmaceutical Research, 2011
To prepare a thermoreversible gel system able to work as a medium for crystallization at around 20°C, allowing easy retrieval of crystals by simply decreasing the gel temperature. Lactose was selected has model substance for crystallization.Water solutions with different% of poloxamer 407, α-Lactose monohydrate, and ethanol were prepared and analysed ...
CESPI, MARCO, BONACUCINA, Giulia, Luca Casettari, Giovanna Mencarelli, PALMIERI, Giovanni Filippo   +4 more
openaire   +4 more sources

Enhanced Oral Bioavailability of Ibuprofen in Rats by Poloxamer Gel Using Poloxamer 188 and Menthol

Drug Development and Industrial Pharmacy, 2005
To improve the oral bioavailability of poorly water-soluble ibuprofen with poloxamer and menthol, the effects of menthol and poloxamer 188 on the aqueous solubility of ibuprofen were investigated. The dissolution and pharmacokinetic study of ibuprofen delivered by the ibuprofen-loaded preparations composed of poloxamer 188 and menthol were then ...
Chul Soon, Yong, Mi-Kyung, Lee, Young-Joon, Park, Kyung-Hwan, Kong, Jing Ji, Xuan, Ji-Hyun, Kim, Jung-Ae, Kim, Won Seok, Lyoo, Sung Soo, Han, Jong-Dal, Rhee, Jong Oh, Kim, Chae Ha, Yang, Chong-Kook, Kim, Han-Gon, Choi   +13 more
openaire   +2 more sources

Poloxamer-based stimuli-responsive biomaterials

Materials Today: Proceedings, 2018
Abstract Advanced materials are the combination of theory and practice. They pave the way for elegant solutions to the challenges engineers are facing in designing high-performance materials for harsh conditions. Stimuli-response polymers lie in such family as they exhibit strongly sensitive to the surrounding condition.
Payam Zarrintaj, Zahed Ahmadi, Mohammad Reza Saeb, Masoud Mozafari   +3 more
openaire   +1 more source

Rheological properties of poloxamer vehicles

International Journal of Pharmaceutics, 1984
Abstract The rheological behavior of poloxamer vehicles as a function of composition and temperature was evaluated using continuous shear methods. For poloxamer vehicles in the sol state (low concentration and temperature) a linear relationship was observed between shear rate and shear stress. For some of the vehicles, as concentration or temperature
Susan C. Miller, Bernadette R. Drabik
openaire   +1 more source

Permeation of Piroxicam from the Poloxamer Gels

Drug Development and Industrial Pharmacy, 1999
Topical formulations of piroxicam were prepared using poloxamer 407 or poloxamer 188 by a cold method, and the permeation characteristics of piroxicam were evaluated. The permeation rate of piroxicam across the synthetic cellulose membrane and the rat skin decreased as the concentration of poloxamer increased.
S C, Shin, C W, Cho, H K, Choi
openaire   +2 more sources

Effects of additives on phase transitions of Poloxamer 407/Poloxamer 188 mixture and release property of monoolein cubic phase containing the poloxamers

Journal of Industrial and Engineering Chemistry, 2012
Abstract The gelling temperature of Poloxamer 407/Poloxamer 188 (16%/10%) mixture solution increased with increasing amount of surfactants. Among surfactants tested, the order of effectiveness in increasing the gelling temperature was sodium dodecyl sulfate (SDS) > tween 20 > cetyltrimethylammonium chloride (CTAC).
Hee Jin Seo, Jin-Chul Kim
openaire   +1 more source

Poloxamer association in aqueous solution

Journal of Colloid and Interface Science, 1982
Abstract Aqueous solutions of the surface active poly(oxyethylene)-poly(oxypropylene)-poly(oxyethylene) block copolymers (poloxamers) were studied using photon correlation spectroscopy (quasi-elastic light scattering) and viscosity measurements. Poloxamers 184 and 237 showed detectable aggregates at 25° only at concentrations above about 6% with size
A.A Al-Saden, T.L Whateley, A.T Florence
openaire   +1 more source

Physicochemical Characterizations of Piroxicam-Poloxamer Solid Dispersion

Pharmaceutical Development and Technology, 1997
To develop an efficient topical delivery system for piroxicam using poloxamer gel formulation, physicochemical behavior of piroxicam in poloxamer was studied. The gelling property of poloxamer and the solubility of piroxicam in the poloxamer were investigated.
S C, Shin, C W, Cho
openaire   +2 more sources

Determination of poloxamer 188 and poloxamer 407 using high-performance thin-layer chromatography in pharmaceutical formulations

Journal of Pharmaceutical and Biomedical Analysis, 2008
Poloxamers (PXMs) are amphiphilic non-ionic block polymers commonly used in the cosmetic and pharmaceutical industries. In spite of the wide use of PXMs, few studies have dealt with the analysis of these polymers in pharmaceutical preparations. In this work, high-performance thin-layer chromatography (HPTLC) has been used to quantify both PXM-188 and ...
Z, Urbán-Morlán, R, Castro-Ríos, A, Chávez-Montes, L M, Melgoza-Contreras, E, Piñón-Segundo, A, Ganem-Quintanar, D, Quintanar-Guerrero   +6 more
openaire   +2 more sources

Poloxamer 188 as vehicle for injectable diazepam

Journal of Pharmaceutical Sciences, 1980
The significant occurrence of thrombophlebitis in patients administered diazepam intravenously was described recently. This side effect has been attributed to the crystallization of diazepam and its subsequent precipitation upon contact with blood or intravenous fluids.
A V, Prancan, B, Ecanow, R J, Bernardoni, M S, Sadove   +3 more
openaire   +2 more sources