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A Review of Polymeric Micelles and Their Applications

Polymers, 2022
Self-assembly of amphiphilic polymers with hydrophilic and hydrophobic units results in micelles (polymeric nanoparticles), where polymer concentrations are above critical micelle concentrations (CMCs).
S. Perumal, R. Atchudan, Wonmok Lee
semanticscholar   +3 more sources

Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions

Journal of Controlled Release, 2021
Polymeric micelles, i.e. aggregation colloids formed in solution by self-assembling of amphiphilic polymers, represent an innovative tool to overcome several issues related to drug administration, from the low water-solubility to the poor drug ...
Sara Nicoli, Patrizia Santi, Elena Del Favero   +2 more
exaly   +2 more sources

Tumor Microenvironment-Responsive Drug Delivery Based on Polymeric Micelles for Precision Cancer Therapy: Strategies and Prospects

Biomedicines
In clinical practice, drug therapy for cancer is still limited by its inefficiency and high toxicity. For precision therapy, various drug delivery systems, including polymeric micelles self-assembled from amphiphilic polymeric materials, have been ...
Zhu Jin, Majdi Al Amili, Shengrong Guo
doaj   +2 more sources

Multifunctional Polymeric Micelles for Cancer Therapy

Polymers, 2022
Polymeric micelles, nanosized assemblies of amphiphilic polymers with a core–shell architecture, have been used as carriers for various therapeutic compounds.
Geun-Woo Jin, N. S. Rejinold, J. Choy
semanticscholar   +3 more sources

Preparation and optimization of polymeric micelles as an oral drug delivery system for deferoxamine mesylate: in vitro and ex vivo studies

Research in Pharmaceutical Sciences, 2019
Deferoxamine mesylate (DFO) is administered as a slow subcutaneous or intravenous infusion due to its poor oral bioavailability and lack of dose proportionality.
Anayatollah Salimi, Behzad Sharif Makhmal Zadeh, Moloud Kazemi   +2 more
doaj   +2 more sources

Evaluation of the Synthesis and Skin Penetration Pathway of Folate-Conjugated Polymeric Micelles for the Dermal Delivery of Irinotecan and Alpha-Mangostin [PDF]

Pharmaceutics
Background/Objectives: The present study aimed to synthesize folate-conjugated poloxamers and develop polymeric micelles for the dermal delivery of irinotecan and alpha-mangostin for the treatment of melanoma using poloxamer 188 and poloxamer 184, which ...
Thanchanok Sirirak, Thirapit Subongkot
doaj   +2 more sources

Redox-sensitive polymeric micelles with aggregation-induced emission for bioimaging and delivery of anticancer drugs

Journal of Nanobiotechnology, 2021
Background Nano-drug delivery systems show considerable promise for effective cancer therapy. Polymeric micelles have attracted extensive attention as practical nanocarriers for target drug delivery and controlled drug delivery system, however, the ...
Changzhen Sun, Ji Lu, Jun Wang, Ping Hao, Chunhong Li, Lu Qi, Lin Yang, Bin He, Zhirong Zhong, Na Hao   +9 more
doaj   +2 more sources

Enhancement of dissolution and oral bioavailability of lacidipine via pluronic P123/F127 mixed polymeric micelles: formulation, optimization using central composite design and in vivo bioavailability study

Drug Delivery, 2018
This study aims at preparing and optimizing lacidipine (LCDP) polymeric micelles using thin film hydration technique in order to overcome LCDP solubility-limited oral bioavailability. A two-factor three-level central composite face-centered design (CCFD)
Ahmed R. Fares, Aliaa N. ElMeshad, Mohamed A. A. Kassem   +2 more
doaj   +2 more sources

Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders

Journal of Advanced Pharmaceutical Technology & Research, 2018
The easy accessibility of skin made dermal application, one of the approaches for local drug therapy. Effectiveness of topical drug application is depended on different parameters such as skin barrier properties, physicochemical properties of drug and ...
Behzad Sharif Makhmalzade, Fateme Chavoshy   +1 more
doaj   +2 more sources

Comparative Stability of Synthetic and Natural Polymeric Micelles in Physiological Environments: Implications for Drug Delivery [PDF]

Pharmaceutics
Polymeric micelles are widely studied as nanocarriers for hydrophobic drugs, yet their structural stability under physiological conditions remains a major limitation.
Hurriyet Polat, Merve Cevik Eren, Mehmet Polat, Kyle M. Koss, Onur K. Polat   +4 more
doaj   +2 more sources