Polymeric Micelles: Morphology, Synthesis, and Pharmaceutical Application [PDF]
E3S Web of Conferences, 2021 Polymeric micelles (PMs) are nanosized core-shell molecules formed by the self-assembly of amphiphilic block copolymers. Their unique morphologies, biocompatibility have allowed them to serve as drug carriers and have found wide applications in the ...
Bai Kun, Wang Anda
doaj +2 more sources
Evaluation of the Synthesis and Skin Penetration Pathway of Folate-Conjugated Polymeric Micelles for the Dermal Delivery of Irinotecan and Alpha-Mangostin [PDF]
PharmaceuticsBackground/Objectives: The present study aimed to synthesize folate-conjugated poloxamers and develop polymeric micelles for the dermal delivery of irinotecan and alpha-mangostin for the treatment of melanoma using poloxamer 188 and poloxamer 184, which ...
Thanchanok Sirirak, Thirapit Subongkot
doaj +2 more sources
Comparative Stability of Synthetic and Natural Polymeric Micelles in Physiological Environments: Implications for Drug Delivery [PDF]
PharmaceuticsPolymeric micelles are widely studied as nanocarriers for hydrophobic drugs, yet their structural stability under physiological conditions remains a major limitation.
Hurriyet Polat +4 more
doaj +2 more sources
Nose-to-brain administration of cannabidiol-loaded polymeric micelles improves the core behavioral symptoms of autism spectrum disorder [PDF]
Bioactive MaterialsNeurodevelopmental disorders including autism spectrum disorder (ASD) affect 5.9% of the global population. Research shows the potential therapeutic use of cannabidiol (CBD) to treat different neurodevelopmental disorders, including ASD.
Rania Awad +5 more
doaj +2 more sources
Biomaterials Research, 2022 Background Superparamagnetic iron oxide nanoparticles (SPIO) have been applied for decades to design theranostic polymeric micelles for targeted cancer therapy and diagnostic MR imaging. However, the effects of SPIO on the physicochemical, and biological
Yixin Jiang +5 more
doaj +1 more source
Intracellular K+-Responsive Block Copolymer Micelles for Targeted Drug Delivery of Curcumin
Frontiers in Bioengineering and Biotechnology, 2022 Curcumin (CUR) is a natural bioactive compound that has attracted attention as a “golden molecule” due to its therapeutic properties against several types of tumors.
Mingyue Jiang +19 more
doaj +1 more source
Hypoxia-Responsive Polymeric Micelles for Enhancing Cancer Treatment
Frontiers in Chemistry, 2020 Polymeric drug vectors have shown great potentials in cancer therapy. However, intelligent controlled release of drugs has become a major challenge in nanomedicine research.
Huayang Feng +8 more
doaj +1 more source
Pharmaceuticals, 2022 In this study, the effect of Cremophor® RH 40 (CR 40) classic micelles and Soluplus® (SP) polymeric micelles were investigated on a novel granule-type drug-delivery system containing megestrolacetate (MGA).
Gábor Katona +4 more
doaj +1 more source
Frontiers in Chemistry, 2021 Chemotherapy is one of the commonly used therapies for the treatment of malignant tumors. Insufficient drug-loading capacity is the major challenge for polymeric micelle–based drug delivery systems of chemotherapy.
Man Zhou +11 more
doaj +1 more source
Development of Polymeric Micelles of Oleanolic Acid and Evaluation of Their Clinical Efficacy
Nanoscale Research Letters, 2020 Oleanolic acid has been used only as a subsidiary agent in cosmetic products. The aim of the study is to show the effect of oleanolic acid as an active ingredient for the alleviation of wrinkles in humans and to develop a polymeric micelle formulation ...
Joo Young An +6 more
doaj +1 more source