Results 71 to 80 of about 2,211,450 (296)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Numerical Study of Forced Air Cooling of a Heated Porous Foam Pyramid Array
Journal of Applied Fluid Mechanics, 2015 The current study employs CFD to study the forced air cooling of a pyramid shaped porous foam absorber. Herein, a three by three (33) array of porous foam absorbers heated with an external heat flux is modeled using the differential equations governing ...
Anderson Kevin +2 more
doaj
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Emergence of physiological oscillation frequencies in a computer model of neocortex
Frontiers in Computational Neuroscience, 2011 Coordination of neocortical oscillations has been hypothesized to underlie the binding essential to cognitive function. However, the mechanisms that generate neocortical oscillations in physiological frequency bands remain unknown.
Samuel A Neymotin +11 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2015 We investigate the mean number of real zeros over an interval $[a,b]$ of a random trigonometric polynomial of the form $\sum_{k=1}^n a_k \cos(kt)+b_k \sin(kt)$ where the coefficients are i.i.d. random variables.
Angst, Jürgen, Poly, Guillaume
core +1 more source
Herpetofauna of the Little South Fork Basin (Cumberland River Drainage), Wayne and McCreary Counties, Kentucky [PDF]
, 1999 Author Institution: Department of Zoology, Southern Illinois UniversityAmphibians and reptiles were surveyed along Little South Fork (tributary of the Cumberland River) and other sites within the drainage basin from May-October 1996 and April-May 1997 to
Poly, William J.
core
Nucleic Acids Research, 1978 Alkaline titrations of different samples of poly(dG).poly(dC) and of the constituent homopolymers poly(dG) and poly(dC) have been performed in 0.15 M NaCl and their CD spectra followed. Sample I contained a slight excess of poly(dC) (52% C: 48% G) and showed a single reversible transition (pK = 11.9) due to the dissociation of double stranded poly(dG ...
C, Marck, D, Thiele
openaire +3 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Orthopaedic SurgeryObjective Minimally invasive reduction and intramedullary nailing (IMN) are the most common strategies used to treat subtrochanteric femur fractures (SFF).
Teng Ma +9 more
doaj +1 more source