Results 51 to 60 of about 773,117 (268)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Numerical Study of Forced Air Cooling of a Heated Porous Foam Pyramid Array

Journal of Applied Fluid Mechanics, 2015
The current study employs CFD to study the forced air cooling of a pyramid shaped porous foam absorber. Herein, a three by three (33) array of porous foam absorbers heated with an external heat flux is modeled using the differential equations governing ...
Anderson Kevin, Maryam Shafahi, Alfredo Guiterrez   +2 more
doaj  

Emergence of physiological oscillation frequencies in a computer model of neocortex

Frontiers in Computational Neuroscience, 2011
Coordination of neocortical oscillations has been hypothesized to underlie the binding essential to cognitive function. However, the mechanisms that generate neocortical oscillations in physiological frequency bands remain unknown.
Samuel A Neymotin, Heekyung eLee, Eunhye ePark, Andre A Fenton, Andre A Fenton, Andre A Fenton, Andre A Fenton, William W Lytton, William W Lytton, William W Lytton, William W Lytton, William W Lytton   +11 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Engineered telecom emission and controlled positioning of Er3+ enabled by SiC nanophotonic structures

Nanophotonics, 2020
High-precision placement of rare-earth ions in scalable silicon-based nanostructured materials exhibiting high photoluminescence (PL) emission, photostable and polarized emission, and near-radiative-limited excited state lifetimes can serve as critical ...
Tabassum Natasha, Nikas Vasileios, Kaloyeros Alex E., Kaushik Vidya, Crawford Edward, Huang Mengbing, Gallis Spyros   +6 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Frontier in special needs education and climate change: a thematic review

Discover Education
The intersection of special needs education and climate change posed (poses) significant challenges, particularly in regions highly vulnerable to environmental disruptions. This thematic review employed (employs) the PRISMA method to conduct a systematic
Mohd Zuri Ghani, Mohamad Nizam Adhaa Kamarudin, Muhamad Fitri Radzuan, Muhammad Amran, Muhammad Amin Mustapa, Mohd Noor Afiq Ramlee, Mohd Hafiz Jaafar, Zahrah Binti Yahya   +7 more
doaj   +1 more source

Building Resilience during Compassion Fatigue: Autoethnographic Accounts of College Students and Faculty

Education Sciences
Compassion fatigue (CF) is a well-researched topic in the fields of mental health and nursing. However, studies on CF in the fields of primary, secondary, and higher education are very recent and scant.
Riley N. Nelson, Amanda Johnson Bertucci, Sara Swenson, Angel Seguine, Meenal Rana   +4 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source