Results 51 to 60 of about 751,096 (269)

Building Resilience during Compassion Fatigue: Autoethnographic Accounts of College Students and Faculty

Education Sciences
Compassion fatigue (CF) is a well-researched topic in the fields of mental health and nursing. However, studies on CF in the fields of primary, secondary, and higher education are very recent and scant.
Riley N. Nelson, Amanda Johnson Bertucci, Sara Swenson, Angel Seguine, Meenal Rana   +4 more
doaj   +1 more source

Emergence of physiological oscillation frequencies in a computer model of neocortex

Frontiers in Computational Neuroscience, 2011
Coordination of neocortical oscillations has been hypothesized to underlie the binding essential to cognitive function. However, the mechanisms that generate neocortical oscillations in physiological frequency bands remain unknown.
Samuel A Neymotin, Heekyung eLee, Eunhye ePark, Andre A Fenton, Andre A Fenton, Andre A Fenton, Andre A Fenton, William W Lytton, William W Lytton, William W Lytton, William W Lytton, William W Lytton   +11 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Numerical Study of Forced Air Cooling of a Heated Porous Foam Pyramid Array

Journal of Applied Fluid Mechanics, 2015
The current study employs CFD to study the forced air cooling of a pyramid shaped porous foam absorber. Herein, a three by three (33) array of porous foam absorbers heated with an external heat flux is modeled using the differential equations governing ...
Anderson Kevin, Maryam Shafahi, Alfredo Guiterrez   +2 more
doaj  

Selective and competitive removal of three basic dyes from single, binary and ternary systems in aqueous solutions: A combined experimental and theoretical study

Journal of Saudi Chemical Society, 2020
The present study evaluates the selective and competitive adsorption of three basic dyes, namely, Basic blue 9 (BB9), Basic blue 41 (BB41) and Basic yellow 28 (BY28) from single, binary and ternary solutions onto natural safiot clay (NSC).
Aziz El Kassimi, Aziz Boutouil, Mamoune El Himri, My Rachid Laamari, Mohammadine El Haddad   +4 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Comparison of a New Minimally Invasive Reduction Technique Using Open Wiring in the Treatment of Subtrochanteric Femur Fractures

Orthopaedic Surgery
Objective Minimally invasive reduction and intramedullary nailing (IMN) are the most common strategies used to treat subtrochanteric femur fractures (SFF).
Teng Ma, Chaofeng Wang, Qiang Huang, Hua Lin, Qian Wang, Cheng Ren, Yibo Xu, Kun Zhang, Congming Zhang, Deyin Liu   +9 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Complete disproportionation of duplex poly(dT)*poly(dA) into triplex poly(dT)*poly(dA)*poly(dT) and poly(dA) by coralyne.

Nucleic acids research, 2002
Coralyne is a small crescent-shaped molecule known to intercalate duplex and triplex DNA. We report that coralyne can cause the complete and irreversible disproportionation of duplex poly(dT)*poly(dA). That is, coralyne causes the strands of duplex poly(dT)*poly(dA) to repartition into equal molar equivalents of triplex poly(dT)*poly(dA)*poly(dT) and ...
Matjaz, Polak, Nicholas V, Hud
openaire   +1 more source