Results 51 to 60 of about 759,541 (219)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Emergence of physiological oscillation frequencies in a computer model of neocortex

Frontiers in Computational Neuroscience, 2011
Coordination of neocortical oscillations has been hypothesized to underlie the binding essential to cognitive function. However, the mechanisms that generate neocortical oscillations in physiological frequency bands remain unknown.
Samuel A Neymotin, Heekyung eLee, Eunhye ePark, Andre A Fenton, Andre A Fenton, Andre A Fenton, Andre A Fenton, William W Lytton, William W Lytton, William W Lytton, William W Lytton, William W Lytton   +11 more
doaj   +1 more source

Engineered telecom emission and controlled positioning of Er3+ enabled by SiC nanophotonic structures

Nanophotonics, 2020
High-precision placement of rare-earth ions in scalable silicon-based nanostructured materials exhibiting high photoluminescence (PL) emission, photostable and polarized emission, and near-radiative-limited excited state lifetimes can serve as critical ...
Tabassum Natasha, Nikas Vasileios, Kaloyeros Alex E., Kaushik Vidya, Crawford Edward, Huang Mengbing, Gallis Spyros   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Numerical Study of Forced Air Cooling of a Heated Porous Foam Pyramid Array

Journal of Applied Fluid Mechanics, 2015
The current study employs CFD to study the forced air cooling of a pyramid shaped porous foam absorber. Herein, a three by three (33) array of porous foam absorbers heated with an external heat flux is modeled using the differential equations governing ...
Anderson Kevin, Maryam Shafahi, Alfredo Guiterrez   +2 more
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Comparison of a New Minimally Invasive Reduction Technique Using Open Wiring in the Treatment of Subtrochanteric Femur Fractures

Orthopaedic Surgery
Objective Minimally invasive reduction and intramedullary nailing (IMN) are the most common strategies used to treat subtrochanteric femur fractures (SFF).
Teng Ma, Chaofeng Wang, Qiang Huang, Hua Lin, Qian Wang, Cheng Ren, Yibo Xu, Kun Zhang, Congming Zhang, Deyin Liu   +9 more
doaj   +1 more source

Building Resilience during Compassion Fatigue: Autoethnographic Accounts of College Students and Faculty

Education Sciences
Compassion fatigue (CF) is a well-researched topic in the fields of mental health and nursing. However, studies on CF in the fields of primary, secondary, and higher education are very recent and scant.
Riley N. Nelson, Amanda Johnson Bertucci, Sara Swenson, Angel Seguine, Meenal Rana   +4 more
doaj   +1 more source

Selective and competitive removal of three basic dyes from single, binary and ternary systems in aqueous solutions: A combined experimental and theoretical study

Journal of Saudi Chemical Society, 2020
The present study evaluates the selective and competitive adsorption of three basic dyes, namely, Basic blue 9 (BB9), Basic blue 41 (BB41) and Basic yellow 28 (BY28) from single, binary and ternary solutions onto natural safiot clay (NSC).
Aziz El Kassimi, Aziz Boutouil, Mamoune El Himri, My Rachid Laamari, Mohammadine El Haddad   +4 more
doaj   +1 more source