Harnessing chitosan and poly-(γ-glutamic acid)-based biomaterials towards cancer immunotherapy
Materials Today Advances, 2022 Cancer-related immunosuppression is one of the most challenging aspects of cancer therapy, being one of the principal causes of disease relapse. Most recent immunotherapeutic strategies have been at the forefront of therapies to overcome this problem ...
Beatriz V. Lima +4 more
doaj +1 more source
Synthesis and structural characterization of bioactive PHA and γ-PGA oligomers for potential applications as a delivery system [PDF]
, 2016 The (trans)esterification reaction of bacterial biopolymers with a selected bioactive compound with a hydroxyl group was applied as a convenient method for obtaining conjugates of such compound.
Covas +6 more
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Bacterial-derived Polymer Poly-y-Glutamic Acid (y-PGA)-based micro/nanoparticles as a delivery system for antimicrobials and other biomedical applications [PDF]
, 2017 : In the past decade, poly-γ-glutamic acid (γ-PGA)-based micro/nanoparticles have garnered remarkable attention as antimicrobial agents and for drug delivery, owing to their controlled and sustained-release properties, low toxicity, as well as ...
Adamus, Grazyna +7 more
core +2 more sources
Materials Today Bio, 2022 We report a highly stretchable hydrogel based on the crosslinking structure between calcium cations and alendronates (ALN) conjugated with poly-γ-glutamate (γ-PGA), a typical biodegradable polymer.
Masahiko Nakamoto +5 more
doaj +1 more source
Assembly of Conducting Polymer and Biohydrogel for the Release and Real-Time Monitoring of Vitamin K3 [PDF]
, 2018 In this work, we report the design and fabrication of a dual-function integrated system to monitor, in real time, the release of previously loaded 2-methyl-1,4-naphthoquinone (MeNQ), also named vitamin K3.
Alemán Llansó, Carlos +3 more
core +2 more sources
A Strategy for Dual Biopolymer Production of P(3HB) and γ-PGA [PDF]
, 2017 BACKGROUND Production of biopolymers has gained considerable attention because of their biodegradability, biocompatibility, and as suitable replacements for mineral-based polymers.
Keshavarz, T. +5 more
core +1 more source
Acta Pharmaceutica Sinica B, 2019 The safety of nanomaterials, a crucial consideration for clinical translation, is enhanced by using building blocks that are biologically nontoxic. Here, we used poly(γ-glutamic acid) (γ-PGA) and dopamine as building blocks of polymeric nanomaterials for
Dongyoon Kim +3 more
doaj +1 more source
Effect of poly-α, γ, L-glutamic acid as a capping agent on morphology and oxidative stress-dependent toxicity of silver nanoparticles [PDF]
, 2011 Highly stable dispersions of nanosized silver particles were synthesized using a straightforward, cost-effective, and ecofriendly method. Nontoxic glucose was utilized as a reducing agent and poly- α, γ, L-glutamic acid (PGA), a naturally occurring ...
Filipič, Metka +4 more
core +3 more sources
Immunomodulatory Effect of Toll-Like Receptor-3 Ligand Poly I:C on Cortical Spreading Depression [PDF]
, 2009 The release of inflammatory mediators following cortical spreading depression (CSD) is suggested to play a role in pathophysiology of CSD-related neurological disorders.
Aghabarari, A. +8 more
core +3 more sources
Improving survival of probiotic bacteria using bacterial poly-γ-glutamic acid [PDF]
, 2014 A major hurdle in producing a useful probiotic food product is bacterial survival during storage and ingestion. The aim of this study was to test the effect of γ-PGA immobilisation on the survival of probiotic bacteria when stored in acidic fruit juice ...
Bartlett, T. +7 more
core +1 more source