Results 41 to 50 of about 23,072 (179)

Effect of polymer topology on non-covalent polymer-protein complexation: miktoarm versus linear mPEG-poly(glutamic acid) copolymers [PDF]

, 2017
Non-covalent polymer-protein conjugation is emerging as a potential route to improve pharmacokinetics and pharmacodynamics of protein therapeutics. In this study, a family of structurally related block copolymers of mPEG2k - poly(glutamic acid) with ...
Bosquillon, Cynthia, Childerhouse, Nick, Conte, Claudia, Di Antonio, Marco, Falcone, Franco H., Mantovani, Giuseppe, Nieto-Orellana, Alejandro, Stolnik, Snow   +7 more
core   +2 more sources

Metabolic engineering of Bacillus amyloliquefaciens LL3 for enhanced poly‐γ‐glutamic acid synthesis

Microbial Biotechnology, 2019
Summary Poly‐γ‐glutamic acid (γ‐PGA) is a biocompatible and biodegradable polypeptide with wide‐ranging applications in foods, cosmetics, medicine, agriculture and wastewater treatment.
Weixia Gao, Yulian He, Fang Zhang, Fengjie Zhao, Chao Huang, Yiting Zhang, Qiang Zhao, Shufang Wang, Chao Yang   +8 more
doaj   +1 more source

Block copolypeptide nanoparticles for the delivery of ocular therapeutics [PDF]

, 2014
Self-assembling block copolypeptides were prepared by sequential ring-opening polymerization of N-carboxyanhydride (NCA) derivatives of γ-benzyl-L-glutamic acid and ε-carbobenzyloxy-L-lysine, followed by selective deprotection of the benzyl glutamate ...
Andrés-Guerrero, Vanessa, Caballo Gonzalez, Maria, Cameron, Neil R., Dose, Anica, Groenen, Alexander J.J., Hehir, Sarah, Herrero Vanrell, Rocio, Stukenkemper, Timo   +7 more
core   +1 more source

Comparative transcriptomics reveal different genetic adaptations of biofilm formation in Bacillus subtilis isolate 1JN2 in response to Cd2+ treatment

Frontiers in Microbiology, 2022
Biofilm plays important roles in the life cycle of Bacillus species, such as promoting host and object surface colonization and resisting heavy metal stress.
Wei Yang, Wei Yang, Haixia Yan, Guanghui Dong, Zhengpeng Li, Zhengpeng Li, Chunhao Jiang, Dalu Gu, Dongdong Niu, Danni Zhou, Yuming Luo, Yuming Luo   +11 more
doaj   +1 more source

Modification of microbial polymers by thiol-ene click reaction: Nanoparticle formation and drug encapsulation [PDF]

, 2016
Comb-like amphiphilic polymers were obtained by grafting long paraffinic chains on microbial poly(¿,dl-glutamic acid) and poly(ß,l-malic acid) through two steps, i.e.
García Álvarez, Montserrat, Lanz, Alberto, Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon, Muñoz Guerra, Sebastián   +3 more
core   +2 more sources

Molecular and structural characterization of a Bacillus cereus strain producing an anthrax-like capsule

Microbiology Spectrum
Bacillus cereus is a ubiquitous Gram-positive, spore-forming, rod-shaped saprophytic bacterium, occasionally reported to cause food-borne illnesses. However, instances of B.
Prashant Dahal, Thi Hai Au La, Md Samun Sarker, Liyanage Devthilini Fernando, Jiri Vlach, Parastoo Azadi, Michael H. Norris   +6 more
doaj   +1 more source

PEG Branched Polymer for Functionalization of Nanomaterials with Ultralong Blood Circulation

, 2009
Nanomaterials have been actively pursued for biological and medical applications in recent years. Here, we report the synthesis of several new poly(ethylene glycol) grafted branched-polymers for functionalization of various nanomaterials including carbon
Adams M. L., Ashiuchi M., Bruchez M., Chan W. C. W., Chatterjee T., Chen R. J., Chen Z., Cheng Y., Cognet L., Dieckmann G. R., Dubertret B., Fan H. Y., Gao M. Y., Gerion D., Han G., Huff T. B., Ipe B. I., Jiang W., Kam N. W. S., Kam N. W. S., Kanaras A. G., Karajanagi S. S., Kogan M. J., Kryachko E. S., Lin Wang W. Z., Liu W. H., Liu Z., Liu Z., LizMarzan L. M., Markowitz M. A., Maubach G., Mulder W. J. M., Nakayama-Ratchford N., Nam J. M., Nath N., Numata M., Oyelere A. K., O’Connell M. J., Paciotti G. F., Parveen S., Pinaud F., Porta F., Richard C., Schultz S., Selvan S. T., Sinani V. A., Sinha N., Sohn B. H., Sonnichsen C., Thaxton C. S., Tong L., Wang D., Welsher K., Williams K. A., Xiaoming Sun Z. L., Yang S. T., Zhelev Z., Zheng M., Zheng M.   +58 more
core   +1 more source

Synthesis and properties of Poly(L-lactide)-b-poly (L-phenylalanine) hybrid copolymers [PDF]

, 2014
Hybrid materials constituted by peptides and synthetic polymers have nowadays a great interest since they can combine the properties and functions of each constitutive block, being also possible to modify the final characteristics by using different ...
Planellas Oates, Marc, Puiggalí Bellalta, Jordi   +1 more
core   +3 more sources

Identification of Key Metabolites in Poly-γ-Glutamic Acid Production by Tuning γ-PGA Synthetase Expression

Frontiers in Bioengineering and Biotechnology, 2020
Poly-γ-glutamic acid (γ-PGA) production is commonly achieved using glycerol, citrate, and L-glutamic acid as substrates. The constitutive expression of the γ-PGA synthetase enabled γ-PGA production with Bacillus subtilis from glucose only. The precursors
Birthe Halmschlag, Sastia P. Putri, Eiichiro Fukusaki, Lars M. Blank   +3 more
doaj   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source