Results 131 to 140 of about 122,513 (306)

A score for predicting risk of death from cardiovascular disease in adults with raised blood pressure, based on individual patient data from randomised controlled trials. [PDF]

, 2001
OBJECTIVE: To create a risk score for death from cardiovascular disease that can be easily used. DESIGN: Data from eight randomised controlled trials of antihypertensive treatment. SETTING: Europe and North America.
Pocock, SJ, Fagard, RH, McCormack, V, Boutitie, F, Gueyffier, F, Boissel, JP   +5 more
core   +1 more source

Comparative analysis of cellular immune responses in treated Leishmania patients and hamsters against recombinant Th1 stimulatory proteins of Leishmania donovani

Frontiers in Microbiology, 2016
Our prior studies demonstrated that cellular response of T helper 1 (Th1) type was generated by a soluble antigenic fraction (ranging from 89.9–97.1 kDa) of Leishmania donovani promastigote, in treated Leishmania patients as well as hamsters and showed ...
SUMIT eJOSHI, Narendra Kumar Yadav, Keerti eRawat, Chandradev Pati Tripathi, Anil Kumar Jaiswal, Prashant eKhare, Rati eTandon, Rajendra Kumar Baharia, Sanchita eDas, Reema eGupta, Pramod Kumar Kushawaha, Shyam eSundar, Amogh Anant Sahasrabuddhe, Anuradha eDube   +13 more
doaj   +1 more source

A Millimeter‐Scale Implantable Magneto–Mechano–Electric Transducer Based on BTO Piezoelectric Ceramics for Remote Wireless Electrical Stimulation of Injured Sciatic Nerves

Advanced Science, EarlyView.
We report a fully wireless, circuit‐free neural stimulator built on a millimetric magneto‐mechano‐electric (MME) cantilever transducer (3 × 10 × 5 mm) with a barium titanate (BTO) piezoelectric ceramic core. Under low‐frequency alternating magnetic fields, the MME cantilever mechanically oscillates, inducing stress on the BTO element and thereby ...
Yijing Wang, Jingyu Tian, Zhe Xu, Cuiling Zhang, Jingen Wu, Ming Liu, Zhilu Ye, Xiaohui Zhang   +7 more
wiley   +1 more source

Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins.

, 2017
Cell-to-cell transmission of protein aggregates is an emerging theme in neurodegenerative disease. Here, we analyze the dipeptide repeat (DPR) proteins that form neuronal inclusions in patients with hexanucleotide repeat expansion C9orf72, the most ...
Michaelsen, M., Farny, D., Mori, K., Klopstock, T., Zhou, Q., Edbauer, D., Lehmer, C., Arzberger, T., Schreiber, F., Kuhm, C., Hermann, A., Haass, C., Baumjohann, D., Greiling, J., May, S., Schludi, M.H., Alterauge, D., Feederle, R., Flatley, A.   +18 more
core   +1 more source

Poly-basic peptides and polymers as new drug candidates against Plasmodium falciparum

Malaria Journal
Background Plasmodium falciparum, the malaria-causing parasite, is a leading cause of infection-induced deaths worldwide. The preferred treatment approach is artemisinin-based combination therapy, which couples fast-acting artemisinin derivatives with ...
Roshan Sivakumar, Katherine Floyd, Jessey Erath, Alex Jacoby, Jenny Kim Kim, Peter O. Bayguinov, James A. J. Fitzpatrick, Dennis Goldfarb, Marko Jovanovic, Abhai Tripathi, Sergej Djuranovic, Slavica Pavlovic-Djuranovic   +11 more
doaj   +1 more source

Hair Follicle Seedling Cryomicroneedles from Hierarchical Microfluidic Organoid on a Chip

Advanced Science, EarlyView.
In this paper, a hierarchical microfluidic chip is developed to produce uniform hair follicle organoids (HFOs) in cryomicroneedles. Cryopreservation agents encapsulate HFOs, preserving viability and hair growth potential. The cryomicroneedles enable simple intradermal transplantation with good skin penetration.
Xinyue Cao, Dongyu Xu, Minhui Lu, Yuanjin Zhao   +3 more
wiley   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences

, 2015
The Dnmt2 RNA methyltransferase catalyses the methylation of C38 in the anticodon loop of tRNA-Asp, but the molecular role of this methylation is unknown.
Jurkowski, Tomasz P, Jeltsch, Albert, Helm, Mark, Kaiser, Steffen, Shanmugam, Raghuvaran, Fierer, Jacob   +5 more
core   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Produção de poli(3-hidroxibutirato) por linhagens de Escherichia coli DH5a e JM101 recombinantes [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de AlimentosPoli-hidroxialcanoatos (PHAs) são uma família de polímeros biodegradáveis que muitos micro-organismos são capazes de ...
Zanfonato, Kellen
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