Results 161 to 170 of about 122,513 (306)

A mouse model of mechanical stress injury to the basal ganglia using thermosensitive PNIPAM hydrogel for intracerebral hemorrhage research

Animal Models and Experimental Medicine, EarlyView.
In this study, we established a novel mouse model of intracerebral hemorrhage (ICH) by stereotactically injecting thermosensitive PNIPAM hydrogel into the internal capsule to impose localized mechanical stress on the corticospinal tract, which provides a straightforward and reproducible tool for preclinical studies on focal mechanical stress–induced ...
Mingxi Li, Yujie Chen, Rongsu Huang, Min Xia, Chao Mi, Yuan Tian, Peiwen Guo, Taotao Jin, Shilei Hao, Hua Feng, Yujie Chen, Zhi Chen   +11 more
wiley   +1 more source

Ribosome transfer via tunnelling nanotubes rescues protein synthesis in pancreatic cancer cells

Cell Communication and Signaling
Background Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the deadliest types of cancer. Tunnelling nanotubes (TNTs) are thin, membranous, intercellular communication structures observed in normal and cancer cells, where they mediate the
Stanislava Martínková, Denisa Jansová, Jana Vorel, Lucie Josefa Lamačová, Petr Daniel, Michael Hudec, Mário Boďo, Jan Hajer, Andrej Susor, Jan Trnka   +9 more
doaj   +1 more source

Polyinosinic-polycytidylic acid modulates Porphyromonas gingivalis-induced cell apoptosis via the janus kinase/ signal transducer and activator of transcription signaling pathway

Journal of Dental Sciences
Background/Purpose: Porphyromonas gingivalis (P. gingivalis) has been shown to induce apoptosis in endothelial cells and contribute to the progression of atherosclerosis.
Shengnan Zhang, Jianru Liu, Xiangying Ouyang, Wenyi Liu, Yuanbo Wang, Jinsheng Zhong   +5 more
doaj   +1 more source

Hyperacute Interleukin‐1β Production and Neutrophil Extracellular Trap Formation in the Cerebral Circulation of Stroke Patients with Large Vessel Occlusion

Annals of Neurology, EarlyView.
Acute ischemic stroke due to large vessel occlusion is associated with rapid intravascular immune activation. Analysis of arterial blood sampled distal to the thrombus during mechanical thrombectomy revealed increased extracellular adenosine triphosphate (ATP) and interleukin‐1β (IL‐1β) levels, evidence of inflammasome priming in monocytes, and ...
Justine Münsterberg, Caspar Brekenfeld, Hanna Englert, Marius Piepke, Regine J. Dress, Martin Oertel, Tina Fischer, Romy Hackbusch, Mingming Zha, Haodi Cai, Christian Casar, Ines S. Schädlich, Leo Winter, Alina Jander, Karoline Degenhardt, Maxim Bester, Fabian Flottmann, Uta Hanning, Brigitte Holst, Anna Worthman, Johanna Hiefner, Berenike Rutz, Eckhard Schlemm, Götz Thomalla, Bettina H. Clausen, Ann M. Stowe, Immo Prinz, Thiruma V. Arumugam, Markus Glatzel, Thomas Renné, Jens Fiehler, Eva Tolosa, Tim Magnus, Mathias Gelderblom   +33 more
wiley   +1 more source

Divalent and multivalent cations control liquid-like assembly of poly(ADP-ribosyl)ated PARP1 into multimolecular associates in vitro

Communications Biology
The formation of nuclear biomolecular condensates is often associated with local accumulation of proteins at a site of DNA damage. The key role in the formation of DNA repair foci belongs to PARP1, which is a sensor of DNA damage and catalyzes the ...
Maria V. Sukhanova, Rashid O. Anarbaev, Ekaterina A. Maltseva, Mikhail M. Kutuzov, Olga I. Lavrik   +4 more
doaj   +1 more source

Natural Aging of Biomaterials in Ambient and Physiological Environments

Advanced NanoBiomed Research, EarlyView.
Biomaterials used in biomedical applications can change their physical properties over time, even under ambient and physiological conditions. This review highlights key studies on the natural aging of materials ranging from soft hydrogels to metals and ceramics, emphasizing how time‐dependent changes influence function and performance.
Shuyu Zhang, Anne E. Staples
wiley   +1 more source

BRCA1 Interacts with Poly(A)-binding Protein [PDF]

Journal of Biological Chemistry, 2006
Eva Dizin, Céline Gressier, Clémence Magnard, Hind Ray, Didier Décimo, Théophile Ohlmann, Nicole Dalla Venezia   +6 more
openaire   +1 more source

Characterization of nuclease stability and poly(A)-binding protein binding activity of chemically modified poly(A) tail for in vivo applications

RSC Chemical Biology
EGF mRNA with optimized chemical modifications of the poly(A) tail showed prolonged protein expression in vivo .
Atsushi Hashimoto, Yuma Kunitomo, Ittoku Kikuchi, Hiroki Yamada, Keiko Kobayashi, Kazuhiro Soshiroda, Hiromi Aman, Yasuaki Kimura, Junichiro Yamamoto, Yasuhisa Shiraishi, Satoshi Uchida, Hiroshi Abe, Hiroto Iwai   +12 more
openaire   +3 more sources

Investigation of endocytosis and cytotoxicity of poly-d, l-lactide-poly(ethylene glycol) micro/nano-particles in osteoblast cells

, 2010
Weijia Wang, Shaobing Zhou, Laiyang Guo, Wei Zhi, Xiaohong Li, Jie WengSchool of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Material, Ministry of Education, Southwest Jiaotong University, Chengdou, Sichuan, People& ...
Shaobing Zhou, Laiyang Guo, et al, Weijia Wang   +3 more
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Estudo da produção de poli-hidroxialcanoatos em Escherichia coli recombinante a partir de soro de queijo [PDF]

, 2011
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de AlimentosOs PHAS são um grupo de poliésteres acumulados sob a forma de grânulos intracelulares por inúmeras bactérias, como ...
Cesca, Karina
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