ESC Heart Failure, Volume 12, Issue 4, Page 3028-3041, August 2025.Abstract Aims Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome accounting for half of heart failure cases. Although natriuretic peptides are the most accepted and extensively used biomarkers for heart failure, their diagnostic accuracy for HFpEF remains debatable.
Reza Parvan +8 more
wiley +1 more source
Widespread intronic polyadenylation diversifies immune cell transcriptomes
bioRxiv, 2017 Alternative cleavage and polyadenylation (ApA) is known to alter untranslated region (3ʹUTR) length but can also recognize intronic polyadenylation (IpA) signals to generate transcripts that lose part or all of the coding region.
I. Singh +8 more
semanticscholar +1 more source
Orthomyxovirus Replication, Transcription, and Polyadenylation
, 2004 Efficient in vitro and in vivo systems are now in place to study the role of viral proteins in replication and/or transcription, the regulation of these processes, polyadenylation of viral mRNAs, the viral promoter structures, or the significance of noncoding regions for virus replication.
Neumann, G +3 more
openaire +3 more sources
Upregulation of Functional Kv11.1a Isoform Expression by Modified U1 Small Nuclear RNA
, 2018 The KCNH2 or human ether-a go-go-related gene (hERG) encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier potassium current in the heart.
Gong, Qiuming +2 more
core
Polyadenylation of histone mRNA in Xenopus oocytes and embryos [PDF]
, 1985 Josiah Ballantine, Hugh R. Woodland
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Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle
FASEB BioAdvances, Volume 7, Issue 8, August 2025.Current model on the effects of acute endurance exercise on the AS regulatory mechanism with key trans‐factors/RBPs (e.g., hnRNP‐A1, ‐A3, and TIA1). ABSTRACT Alternative splicing (AS) is a highly conserved posttranscriptional mechanism, generating mRNA variants to diversify the proteome.
Alexander Ahn +5 more
wiley +1 more source
The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sites. [PDF]
, 1988 Jeffrey Wilusz +2 more
openalex +1 more source
The TP53 tumor suppressor gene: From molecular biology to clinical investigations
Journal of Internal Medicine, Volume 298, Issue 2, Page 78-96, August 2025.Abstract Extensively studied over the past four decades, the TP53 gene has emerged as a pivotal watchman in cellular defense and a key factor in cancer biology. TP53 is the most frequently mutated gene in human malignancies, 50% of which carry alterations to it.
Panagiotis Baliakas, Thierry Soussi
wiley +1 more source
Ere, a Family of Short Interspersed Elements in the Genomes of Odd-Toed Ungulates (Perissodactyla)
AnimalsShort Interspersed Elements (SINEs) are eukaryotic retrotransposons transcribed by RNA polymerase III (pol III). Many mammalian SINEs (T+ SINEs) contain a polyadenylation signal (AATAAA), a pol III transcription terminator, and an A-rich tail in their 3′-
Ilia G. Ustyantsev +4 more
doaj +1 more source
Kinetics and Efficiency of Polyadenylation of Late Polyomavirus Nuclear RNA: Generation of Oligomeric Polyadenylated RNAs and Their Processing into mRNA [PDF]
, 1984 Nicholas H. Acheson
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