Results 1 to 10 of about 9,152,470 (385)

Clinical characteristics and outcomes of hyponatraemia associated with oral water intake in adults: a systematic review

BMJ Open, 2021
Introduction Excessive water intake is rarely associated with life-threatening hyponatraemia. The aim of this study was to determine the clinical characteristics and outcomes of hyponatraemia associated with excess water intake.Methods This review was ...
Martin Howell, Anna Rangan, Gopala K Rangan, Nilofar Dorani, Miranda M Zhang, Lara Abu-Zarour, Ho Ching Lau, Alexandra Munt, Ashley N Chandra, Sayanthooran Saravanabavan, Jennifer Q J Zhang, Annette TY Wong   +11 more
doaj   +1 more source

Effect of Early and Delayed Commencement of Paricalcitol in Combination with Enalapril on the Progression of Experimental Polycystic Kidney Disease

Journal of Cardiovascular Development and Disease, 2021
Vitamin D secosteroids are intranuclear regulators of cellular growth and suppress the renin-angiotensin system. The aim of this study was to test the hypothesis that the vitamin D receptor agonist, paricalcitol (PC), either alone or with enalapril (E ...
Priyanka S. Sagar, Sayanthooran Saravanabavan, Alexandra Munt, Annette T. Y. Wong, Gopala K. Rangan   +4 more
doaj   +1 more source

Efficacy of beetroot juice on reducing blood pressure in hypertensive adults with autosomal dominant polycystic kidney disease (BEET-PKD): study protocol for a double-blind, randomised, placebo-controlled trial

Trials, 2023
Background In autosomal dominant polycystic kidney disease (ADPKD) impaired nitric oxide (NO) synthesis, in part, contributes to early-onset hypertension. Beetroot juice (BRJ) reduces blood pressure (BP) by increasing NO-mediated vasodilation. The aim of
Priyanka S. Sagar, Alexandra Munt, Sayanthooran Saravanabavan, Farnoosh Asghar Vahedi, James Elhindi, Beatrice Nguyen, Katrina Chau, David C. Harris, Vincent Lee, Kamal Sud, Nikki Wong, Gopala K. Rangan   +11 more
doaj   +1 more source

HLA system features in patients on waiting list for kidney transplantation in the Republic of Bashkortostan

Медицинская иммунология, 2022
The aim of our study was to specify the features of the HLA system in patients registered on the waiting list for kidney transplantation in the Republic of Bashkortostan. HLA-A, HLA-B, and HLA-DR phenotypes were assayed by polymerase chain reaction using
A. A. Korzhenevsky, N. P. Korzhenevskaya
doaj   +1 more source

Polycystic Liver Disease: A Case Report

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2021
Polycystic liver disease is characterized by multiple cystic lesions on the liver. Liver cysts are typically incidental findings, with occasional complications including cyst hemorrhage, infection and rupture.
Randy Adiwinata, Natalin Allorerung, Jonathan Arifputra, Andrea Livina, Pearla Lasut, Bradley Jimmy Waleleng, Fandy Gosal, Luciana Rotty, Jeanne Winarta, Andrew Waleleng, Michael Tendean   +10 more
doaj   +1 more source

Polycystic kidney disease

Springer: New York, 2020
Polycystic kidney disease (PKD) is a monogenic, hereditary disorder of the kidneys that leads to fluid-filled cysts within the renal tubes. It is one of the most common causes of end-stage renal failure.
Soo Oh, Rabeet Khan, Ahmed Ziada
semanticscholar   +1 more source

AMPK and Polycystic Kidney Disease Drug Development: An Interesting Off-Target Target

Frontiers in Medicine, 2022
Autosomal Dominant Polycystic Kidney Disease is a genetic disease that causes dramatic perturbations of both renal tissue architecture and of a multitude of cellular signaling pathways.
Michael J. Caplan
doaj   +1 more source

Disrupting polycystin-2 EF hand Ca2+ affinity does not alter channel function or contribute to polycystic kidney disease

Journal of Cell Science, 2020
Approximately 15% of autosomal dominant polycystic kidney disease (ADPKD) is caused by variants in PKD2. PKD2 encodes polycystin-2, which forms an ion channel in primary cilia and endoplasmic reticulum (ER) membranes of renal collecting duct cells ...
T. Vien, L. Ng, Jessica M. Smith, Ke Dong, M. Krappitz, V. Gainullin, S. Fedeles, Peter C Harris, S. Somlo, P. DeCaen   +9 more
semanticscholar   +1 more source

Insights into Autosomal Dominant Polycystic Kidney Disease from Genetic Studies.

American Society of Nephrology. Clinical Journal, 2020
Autosomal dominant polycystic kidney disease is the most common monogenic cause of ESKD. Genetic studies from patients and animal models have informed disease pathobiology and strongly support a "threshold model" in which cyst formation is triggered by ...
M. Lanktree, A. Haghighi, Ighli di Bari, Xuewen Song, Y. Pei   +4 more
semanticscholar   +1 more source

Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease: Evidence and Therapeutic Potential.

American Society of Nephrology. Clinical Journal, 2020
Autosomal dominant polycystic kidney disease is characterized by progressive development and enlargement of kidney cysts, leading to ESKD. Because the kidneys are under high metabolic demand, it is not surprising that mounting evidence suggests that a ...
Kristen L. Nowak, K. Hopp
semanticscholar   +1 more source