Results 31 to 40 of about 9,152,470 (385)

Combined liver-kidney transplant in polycystic diseases: a case report [PDF]

Einstein (São Paulo), 2023
Polycystic liver disease, a hereditary pathology, usually manifests as autosomal dominant polycystic kidney disease. The many cysts in the liver cause massive hepatomegaly, majorly affecting the patient’s quality of life. In cases of refractory symptoms,
Olival Cirilo Lucena da Fonseca Neto, Beatriz Costa Nava Martins, Norma Thomé Jucá, Victor Cruz Rosa Alencar de Sá, Priscylla Jennie Monteiro Rabêlo, Paulo Sérgio Vieira de Melo, Américo Gusmão Amorim, Cláudio Moura Lacerda   +7 more
doaj   +1 more source

Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease

Nature Communications, 2019
Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in either PKD1 or PKD2 genes, is one of the most common human monogenetic disorders and the leading genetic cause of end-stage renal disease.
Edmund C. Lee, T. Valencia, C. Allerson, Annelie E Schairer, Andrea Flaten, Matanel Yheskel, Kara Kersjes, Jian Li, Sole Gatto, Mandeep Takhar, S. Lockton, A. Pavlícek, Michael Kim, Tiffany T Chu, Randy Soriano, Scott Davis, J. Androsavich, Salma Sarwary, Tate Owen, J. Kaplan, Kai-zhen Liu, G. Jang, S. Neben, Philip J. Bentley, T. Wright, V. Patel   +25 more
semanticscholar   +1 more source

The cardiovascular risk of young women with polycystic ovary syndrome: an observational, analytical, prospective case-control study [PDF]

, 2004
To evaluate the cardiovascular risk of polycystic ovary syndrome (PCOS), we investigated lipid profile, metabolic pattern, and echocardiography in 30 young women with PCOS and 30 healthy age- and body mass index (BMI)-matched women. PCOS women had higher
CASCELLA, TERESA, COLAO, ANNAMARIA, F. Zullo, L. Tauchmanovà, LOMBARDI, GAETANO, ORIO, FRANCESCO, PALOMBA, STEFANO, SPINELLI, LETIZIA   +7 more
core   +1 more source

Deep Learning for Polycystic Kidney Disease: Utilizing Neural Networks for Accurate and Early Detection through Gene Expression Analysis [PDF]

arXiv, 2023
With Polycystic Kidney Disease (PKD) potentially leading to fatal complications in patients due to the formation of cysts in kidneys, early detection of PKD is crucial for effective management of the condition. However, the various patient-specific factors that play a role in the diagnosis make it an intricate puzzle for clinicians to solve, leading to
arxiv  

Prevalence Estimates of Polycystic Kidney and Liver Disease by Population Sequencing.

Journal of the American Society of Nephrology, 2018
BACKGROUND Estimating the prevalence of autosomal dominant polycystic kidney disease (ADPKD) is challenging because of age-dependent penetrance and incomplete clinical ascertainment.
M. Lanktree, A. Haghighi, E. Guiard, Ioan-Andrei Iliuta, Xuewen Song, P. Harris, A. Paterson, Y. Pei   +7 more
semanticscholar   +1 more source

Germline Mutations for Kidney Volume in ADPKD

Kidney International Reports, 2022
Introduction: Valid prediction models or predictors of disease progression in children and young patients with autosomal dominant polycystic kidney disease (ADPKD) are lacking.
Hiroshi Kataoka, Rie Yoshida, Naomi Iwasa, Masayo Sato, Shun Manabe, Keiko Kawachi, Shiho Makabe, Taro Akihisa, Yusuke Ushio, Atsuko Teraoka, Ken Tsuchiya, Kosaku Nitta, Toshio Mochizuki   +12 more
doaj  

Could semiquantitative analysis of real-time ultrasound elastography distinguish more liver parenchyma alterations of nonalcoholic fatty liver disease in patients with polycystic ovary syndrome?

Archives of Endocrinology and Metabolism, 2019
Objective: Nonalcoholic fatty liver disease is the commonest diffuse liver disease, of which women with polycystic ovary syndrome are at an increased risk.
Na Di, Xinchuan Zhou, Yaxiao Chen, Xiaomiao Zhao, Lin Li, Linlin Jiang, Baoming Luo, Xiaoli Chen, Dongzi Yang   +8 more
doaj   +1 more source

Modeling Vascular Branching Alterations in Polycystic Kidney Disease [PDF]

arXiv, 2022
The analysis of biological networks encompasses a wide variety of fields from genomic research of protein-protein interaction networks, to the physiological study of biologically optimized tree-like vascular networks. It is certain that different biological networks have different optimization criteria and we are interested in those networks optimized ...
arxiv  

Clinical practice guideline monitoring children and young people with, or at risk of developing autosomal dominant polycystic kidney disease (ADPKD)

BMC Nephrology, 2019
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is thought to affect about 1 in 1000 people in the UK. ADPKD causes a progressive decline in kidney function, with kidney failure tending to occur in middle age.
Jan Dudley, Paul Winyard, Matko Marlais, Oliver Cuthell, Tess Harris, Jiehan Chong, John Sayer, Daniel P. Gale, Lucy Moore, Kay Turner, Sarah Burrows, Richard Sandford   +11 more
doaj   +1 more source

Molecular Mechanisms of Isolated Polycystic Liver Diseases

Frontiers in Genetics, 2022
Polycystic liver disease (PLD) is a rare autosomal dominant disorder including two genetically and clinically distinct forms: autosomal dominant polycystic kidney disease (ADPKD) and isolated polycystic liver disease (PCLD).
Ziqi Yu, Xiang Shen, Chong Hu, Jun Zeng, Aiyao Wang, Jianyong Chen   +5 more
doaj   +1 more source