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Participant Perceptions of Increasing Water Intake in Polycystic Kidney Disease [PDF]

Kidney International Reports
Introduction: Clinical practice guidelines suggest maintaining adequate hydration in people with autosomal dominant polycystic kidney disease (ADPKD). However, the long-term perceptions of increasing water intake and the role of self-efficacy tools are ...
Sneha Amin, Irene Sangadi, Margaret Allman-Farinelli, Neil Boudville, Imad Haloob, David C.H. Harris, Carmel M. Hawley, David W. Johnson, Vincent W. Lee, Jun Mai, Anna Rangan, Simon D. Roger, Kamal Sud, Eswari Vilayur, Gopala K. Rangan   +14 more
doaj   +1 more source

Clinical characteristics and outcomes of hyponatraemia associated with oral water intake in adults: a systematic review

BMJ Open, 2021
Introduction Excessive water intake is rarely associated with life-threatening hyponatraemia. The aim of this study was to determine the clinical characteristics and outcomes of hyponatraemia associated with excess water intake.Methods This review was ...
Martin Howell, Anna Rangan, Gopala K Rangan, Nilofar Dorani, Miranda M Zhang, Lara Abu-Zarour, Ho Ching Lau, Alexandra Munt, Ashley N Chandra, Sayanthooran Saravanabavan, Jennifer Q J Zhang, Annette TY Wong   +11 more
doaj   +1 more source

Effect of Early and Delayed Commencement of Paricalcitol in Combination with Enalapril on the Progression of Experimental Polycystic Kidney Disease

Journal of Cardiovascular Development and Disease, 2021
Vitamin D secosteroids are intranuclear regulators of cellular growth and suppress the renin-angiotensin system. The aim of this study was to test the hypothesis that the vitamin D receptor agonist, paricalcitol (PC), either alone or with enalapril (E ...
Priyanka S. Sagar, Sayanthooran Saravanabavan, Alexandra Munt, Annette T. Y. Wong, Gopala K. Rangan   +4 more
doaj   +1 more source

Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease

Nature Genetics, 2022
Adult kidney organoids have been described as strictly tubular epithelia and termed tubuloids. While the cellular origin of tubuloids has remained elusive, here we report that they originate from a distinct CD24+ epithelial subpopulation.
Yaoxian Xu, C. Kuppe, J. Perales-Patón, Sikander Hayat, Jennifer Kranz, Ali T. Abdallah, J. Nagai, Zhijian Li, Fabian Peisker, Turgay Saritas, M. Halder, Sylvia Menzel, Konrad Hoeft, A. Kenter, Hyojin Kim, Claudia R C van Roeyen, M. Lehrke, J. Moellmann, T. Speer, E. Buhl, R. Hoogenboezem, P. Boor, J. Jansen, C. Knopp, I. Kurth, B. Smeets, E. Bindels, M. Reinders, C. Baan, J. Gribnau, E. Hoorn, J. Steffens, T. Huber, Ivan G. Costa, J. Floege, R. Schneider, J. Saez-Rodriguez, Benjamin S. Freedman, R. Kramann   +38 more
semanticscholar   +1 more source

Efficacy of beetroot juice on reducing blood pressure in hypertensive adults with autosomal dominant polycystic kidney disease (BEET-PKD): study protocol for a double-blind, randomised, placebo-controlled trial

Trials, 2023
Background In autosomal dominant polycystic kidney disease (ADPKD) impaired nitric oxide (NO) synthesis, in part, contributes to early-onset hypertension. Beetroot juice (BRJ) reduces blood pressure (BP) by increasing NO-mediated vasodilation. The aim of
Priyanka S. Sagar, Alexandra Munt, Sayanthooran Saravanabavan, Farnoosh Asghar Vahedi, James Elhindi, Beatrice Nguyen, Katrina Chau, David C. Harris, Vincent Lee, Kamal Sud, Nikki Wong, Gopala K. Rangan   +11 more
doaj   +1 more source

AMPK and Polycystic Kidney Disease Drug Development: An Interesting Off-Target Target

Frontiers in Medicine, 2022
Autosomal Dominant Polycystic Kidney Disease is a genetic disease that causes dramatic perturbations of both renal tissue architecture and of a multitude of cellular signaling pathways.
Michael J. Caplan
doaj   +1 more source

Polycystic kidney disease

Springer: New York, 2020
Polycystic kidney disease (PKD) is a monogenic, hereditary disorder of the kidneys that leads to fluid-filled cysts within the renal tubes. It is one of the most common causes of end-stage renal failure.
Soo Oh, Rabeet Khan, Ahmed Ziada
semanticscholar   +1 more source

Causal relationship between polycystic ovary syndrome and chronic kidney disease: A Mendelian randomization study

Frontiers in Endocrinology, 2023
ObjectivePolycystic ovary syndrome is one of the most common endocrine disorders among women of childbearing age. The relationship between polycystic ovary syndrome and chronic kidney disease remains unclear and controversial.
Yufei Du, Fengao Li, Shiwei Li, Li Ding, Ming Liu   +4 more
doaj   +1 more source

An Empirical Biomarker-based Calculator for Autosomal Recessive Polycystic Kidney Disease - The Nieto-Narayan Formula [PDF]

, 2016
Autosomal polycystic kidney disease (ARPKD) is associated with progressive enlargement of the kidneys fuelled by the formation and expansion of fluid-filled cysts.
Goldberg, Itzhak D., Narayan, Prakash, Nieto, Jake A., Yamin, Michael A.   +3 more
core   +9 more sources

Atypical Polycystic Kidney Disease as defined by Imaging

Scientific Reports, 2023
Using age- and height-adjusted total kidney volume, the Mayo Clinic Imaging Classification provides a validated approach to assess the risk of chronic kidney disease (CKD) progression in autosomal dominant polycystic kidney disease (ADPKD), but requires ...
Ioan-Andrei Iliuta, Aung Zaw Win, Matthew B. Lanktree, Seung Heyck Lee, Marina Pourafkari, Fatemeh Nasri, Elsa Guiard, Amirreza Haghighi, Ning He, Alistair Ingram, Crystal Quist, David Hillier, Korosh Khalili, York Pei   +13 more
doaj   +1 more source