Results 231 to 240 of about 37,931 (246)

Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease

Science Translational Medicine, 2020
Pharmacological induction of NRF2 restores redox homeostasis and slows cystogenesis in mouse models of polycystic kidney disease. Antioxidants dominate ADPKD Autosomal dominant polycystic kidney disease (ADPKD) is a relatively common genetic disorder ...
Yi Lu, Yongzhan Sun, Zhiheng Liu, Yumei Lu, Xu Zhu, Bingxue Lan, Zeyun Mi, Lin Dang, Na Li, Wenlei Zhan, Lu Tan, J. Pi, H. Xiong, Lirong Zhang, Yupeng Chen   +14 more
semanticscholar   +1 more source

Autosomal dominant polycystic kidney disease

The Lancet, 2007
Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal, monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which can be explained to a large extent by its genetic heterogeneity and modifier genes.
Vicente E. Torres, Peter C. Harris, Yves Pirson   +2 more
openaire   +3 more sources

Autosomal Dominant Polycystic Kidney Disease

New England Journal of Medicine, 1990
Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disease occurring in 1 in 200 to 1 in 1,000 individuals. ADPKD is characterized by cystic lesions in the kidneys and often by structural abnormalities in the gastrointestinal tract and cardiovascular system.
openaire   +5 more sources

Autosomal dominant polycystic kidney disease

BMJ, 2016
#### What you need to know Polycystic kidney disease (PKD) is an inherited condition defined by the pathological development of fluid-filled cysts throughout the kidneys leading to organ enlargement (fig 1⇓) and chronic kidney disease. Autosomal dominant polycystic kidney disease (ADPKD) is the commonest inherited kidney disease1 and is the fourth ...
openaire   +3 more sources

Angiogenesis and autosomal dominant polycystic kidney disease

Pediatric Nephrology, 2012
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the growth of multiple cysts that in many cases result in end-stage renal disease. Current strategies to reduce cyst progression in ADPKD focus on modulating cell turnover, fluid secretion, and vasopressin signalling; but an alternative approach may be to target pathways providing
Huang, JL, Woolf, AS, Long, DA
openaire   +4 more sources

Autosomal Dominant Polycystic Kidney Disease

Advances in Kidney Disease and Health
Over 50% of people affected with autosomal dominant polycystic kidney disease (ADPKD) will develop kidney failure, making ADPKD the 4th most common cause of end-stage kidney disease. ADPKD is a systemic condition affecting the kidneys, liver, heart, vasculature, and other organ systems.
Maria Lourdes Gonzalez Suarez, Silvia Titan, Neera K. Dahl   +2 more
openaire   +2 more sources

Autosomal dominant polycystic kidney disease in the fetus

American Journal of Medical Genetics, 1994
AbstractWe report on 3 cases with a fetal presentation of autosomal dominant polycystic kidney disease (ADPKD), which illustrate the variable expression of ADPKD during fetal life. Fetus 1 was diagnosed at 20 weeks of gestation by ultrasonography; a molecular prenatal diagnosis was performed at 10 weeks on fetus 2, a sib of fetus 1; and ADPKD was an ...
Andrée Grignon, Estelle Lamothe, Jacques L. Michaud, D.G. Bichet, Louis Dallaire, David S. Rosenblatt, Pierre Russo, Marie Lambert   +7 more
openaire   +3 more sources

Diagnosis of autosomal dominant polycystic kidney disease

Expert Opinion on Medical Diagnostics, 2008
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and accounts for 5 - 10% of end stage renal disease. Mutations of two genes, PKD1 and PKD2, account for ∼ 85 and ∼ 15% of cases, respectively.This paper reviews the clinical features of ADPKD, highlights the current roles for image- and molecular-based ...
York Pei, Xiao Zhao
openaire   +3 more sources

Hypertension in autosomal dominant polycystic kidney disease

Current Opinion in Nephrology and Hypertension, 1995
Hypertension occurs frequently in autosomal dominant polycystic kidney disease. Increased activity of the renin-angiotensin system contributes to the development and maintenance of hypertension before the development of renal failure. Angiotensin-converting enzyme inhibitors are indicated for treatment of hypertension before the development of renal ...
Brendan J. Barrett, Patrick S. Parfrey
openaire   +2 more sources

Nephrolithiasis in Autosomal Dominant Polycystic Kidney Disease

Journal of Endourology, 2010
Autosomal dominant polycystic kidney disease (ADPKD) manifests with renal and extrarenal abnormalities and is inherited in an autosomal dominant fashion. In addition to multiple renal cysts, abnormalities such as liver cysts (80%), pancreatic cysts, splenic cysts, pulmonary cysts, berry aneurysms in the distribution of arterial circle of Willis (8 ...
Sarath Krishna Nalagatla, Uwais B. Mufti
openaire   +3 more sources