Results 51 to 60 of about 82,732 (241)

Identification, Characterization, and Localization of a Novel Kidney Polycystin-1-Polycystin-2 Complex [PDF]

, 2002
The functions of the two proteins defective in autosomal dominant polycystic kidney disease, polycystin-1 and polycystin-2, have not been fully clarified, but it has been hypothesized that they may heterodimerize to form a "polycystin complex" involved ...
Ackermann, Bergsma, Boletta, Cai, Charron, Chen, Foggensteiner, Gallagher, Gonzalez-Perrett, Green, Grupp, Hanaoka, Huan, Hughes, Ibraghimov Beskrovnaya, Ibraghimov Beskrovnaya, Jat, Jat, Lehtonen, Lohning, Lu, Man, Markowitz, Mochizuki, Moy, Nathke, Obermuller, Olmsted, Ong, Ong, Ong, Ong, Pollack, Pritchard, Putney, Qian, Rothman, Scheffers, Tsiokas, Vassilev, Ward, Watnick, Wu, Xu   +43 more
core   +1 more source

Participant Perceptions of Increasing Water Intake in Polycystic Kidney Disease

Kidney International Reports
Introduction: Clinical practice guidelines suggest maintaining adequate hydration in people with autosomal dominant polycystic kidney disease (ADPKD). However, the long-term perceptions of increasing water intake and the role of self-efficacy tools are ...
Sneha Amin, Irene Sangadi, Margaret Allman-Farinelli, Neil Boudville, Imad Haloob, David C.H. Harris, Carmel M. Hawley, David W. Johnson, Vincent W. Lee, Jun Mai, Anna Rangan, Simon D. Roger, Kamal Sud, Eswari Vilayur, Gopala K. Rangan   +14 more
doaj   +1 more source

Perioperative Management of Hysterectomy in a Patient with Polycystic Kidney Disease [PDF]

Journal of Clinical and Diagnostic Research, 2014
Polycystic disease of the kidney, inherited as an autosomal dominant trait is characterised by progressive expansion of numerous fluidfilled cysts resulting in massive enlargement of the kidneys ultimately resulting in kidney failure. An understanding of
Savitri. K., Ashwini. H.R., Sreedevi. S.
doaj   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Magnetic resonance imaging 3t and total fibrotic volume in autosomal dominant polycystic kidney disease [PDF]

, 2018
INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal hereditary disorder. Several authors have attempted to identify a kidney damage marker for predicting the prognosis and the effectiveness of therapy in ADPKD ...
Ciccariello, Mauro, D'Angelo, Anna Rita, DI GAETA, Alessandro, Ferrigno, Luigina, Lai, Silvia, Letizia, Claudio, Mastroluca, Daniela, Panebianco, Valeria, Perrotta, ADOLFO MARCO, Petramala, Luigi   +9 more
core   +1 more source

Pkd2 dosage influences cellular repair responses following ischemia-reperfusion injury [PDF]

, 2009
Autosomal dominant polycystic kidney disease (ADPKD) results from mutations in either PKD1 or PKD2 and accounts for 10% of all patients on renal replacement therapy. The kidney disease phenotype is primarily characterized by cyst formation, but there are
Haylor, J.L., McDaid, J.P., Ong, A.C.M., Prasad, S., Tam, F.W.K.   +4 more
core   +2 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Combined liver-kidney transplantation: Analysis of patients with preformed lymphocytotoxic antibody [PDF]

, 1988
In this report, we address combined liver-kidney transplantation, with particular attention to the apparent phenomenon of protection of kidney allografts to antibody mediated destruction by liver allografts.
Duquesnoy, R, Fung, J, Gordon, R, Griffin, M, Klintmalm, G, Makowka, L, Starzl, T, Todo, S, Tzakis, A   +8 more
core  

TNF-α blockade is ineffective in animal models of established polycystic kidney disease [PDF]

, 2013
BACKGROUND: Given the large medical burden of polycystic kidney disease (PKD) and recent clinical trial failures, there is a need for novel, safe and effective treatments for the disorder.
Jeffrey Roix, Saurabh Saha
core   +2 more sources

Characterizing the ADPKD-IFT140 Phenotypic Signature With Deep Learning and Advanced Imaging Biomarkers

Kidney International Reports
Introduction: ADPKD-IFT140 is the third most common disease-causing variant in autosomal dominant polycystic kidney disease (ADPKD) after ADPKD-PKD1 and ADPKD-PKD2.
Ahmad Ghanem, Fadi George Munairdjy Debeh, Abdul Hamid Borghol, Nikola Zagorec, Amanda L. Tapia, Byron Smith, Stefan Paul, Abdul Basit, Bassel AlKhatib, Nay Nader, Marie Therese Bou Antoun, Adriana V. Gregory, Hana Yang, Rachel S. Schauer, Neera K. Dahl, Christian Hanna, Vicente E. Torres, Timothy L. Kline, Peter C. Harris, Emilie Cornec-Le Gall, Fouad T. Chebib   +20 more
doaj   +1 more source