Results 51 to 60 of about 1,110,820 (300)
Insulin-like growth factor-1 induces hyperproliferation of PKD1 cystic cells via a Ras/Raf dependent signalling pathway [PDF]
, 2007 Autosomal dominant polycystic kidney disease (ADPKD) largely results from mutations in the PKD1 gene leading to hyperproliferation of renal tubular epithelial cells and consequent cyst formation.
Harris, P.C. +7 more
core +1 more source
Putative roles of cilia in polycystic kidney disease [PDF]
, 2011 The last 10years has witnessed an explosion in research into roles of cilia in cystic renal disease. Cilia are membrane-enclosed finger-like projections from the cell, usually on the apical surface or facing into a lumen, duct or airway.
Jenkins, Dagan, Winyard, Paul
core +1 more source
Genetics of Autosomal Recessive Polycystic Kidney Disease and Its Differential Diagnoses
Frontiers in Pediatrics, 2018 Autosomal recessive polycystic kidney disease (ARPKD) is a hepatorenal fibrocystic disorder that is characterized by enlarged kidneys with progressive loss of renal function and biliary duct dilatation and congenital hepatic fibrosis that leads to portal
C. Bergmann
semanticscholar +1 more source
POLYCYSTIC KIDNEY IN AN INFANT [PDF]
Archives of Pediatrics & Adolescent Medicine, 1918 Cases of polycystic kidney observed in infancy, with necropsy findings, are still sufficiently rare to justify the report of the following case. REPORT OF CASE History. —E. S., of Syrian parentage, born July 1, 1916, of healthy parents. There were several other children in the family who were well and healthy.
openaire +3 more sources
Kidney transcriptome and cystic kidney disease genes in zebrafish
Frontiers in Physiology, 2023 Introduction: Polycystic kidney disease (PKD) is a condition where fluid filled cysts form on the kidney which leads to overall renal failure. Zebrafish has been recently adapted to study polycystic kidney disease, because of its powerful embryology and ...
Matthew Koslow +5 more
doaj +1 more source
Management of Pain in Autosomal Dominant Polycystic Kidney Disease and Anatomy of Renal Innervation [PDF]
, 2015 Purpose Chronic pain is a prominent feature of autosomal dominant polycystic kidney disease that is difficult to treat and manage, often resulting in a decrease in quality of life.
Bacallao, Robert L. +4 more
core +1 more source
Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localisation of polycystin-2 in vivo and in vitro [PDF]
, 2006 PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease (ADPKD). Polycystin-2 (PC2), the PKD2 protein, is a nonselective Ca2 + -permeable cation channel which may function at the cell surface and ER. Nevertheless, the factors
Kane, M.E. +4 more
core +2 more sources
Complications of polycystic kidney disease
Kidney International, 1997 A 33-year-old white man first presented to the Royal Infirmary Stirling, Scotland, 24 years ago with a history of recent-onset hematuria. Intravenous urography at that time showed a filling defect in the right kidney; a subsequent aortogram demonstrated a single simple cyst in the right kidney.
Michael L. Watson
openalex +4 more sources
European Medical Journal Urology, 2020 Horseshoe kidney is the most common renal fusion anomaly occurring in 0.15–0.25% of the general population. Horseshoe kidney is usually asymptomatic but may present with disease-like infections, urolithiasis, malignancy, polycystic disease, and other ...
Ayun Cassell +9 more
doaj +1 more source
British Journal of Pharmacology, 2019 The pathogenic mechanism of autosomal dominant polycystic kidney disease (ADPKD) is unclear. Similar to tumour cells, polycystic kidney cells are primarily dependent on aerobic glycolysis for ATP production. Compared with rodents, miniature pigs are more
Xiaoying Lian +9 more
semanticscholar +1 more source