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GLPG2737, a CFTR Inhibitor, Prevents Cyst Growth in Preclinical Models of Autosomal Dominant Polycystic Kidney Disease.

Am J Nephrol
Dumont V, Meurisse S, Verdonck K, Salgues V, Robert T, Anquetil F, Delachaume C, Blanqué R, Liekens D, Huang Y, Hu J, Harris PC, Nakhlé J, Conrath K, Vandeghinste N, Christophe T, Comas D.   +16 more
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Assessing Risk of Rapid Progression in Autosomal Dominant Polycystic Kidney Disease and Special Considerations for Disease-Modifying Therapy.

American Journal of Kidney Diseases, 2021
Autosomal Dominant Polycystic Kidney Disease is the most common inherited cause of kidney failure accounting for 5-10% of cases. Predicting which patient would progress rapidly to kidney failure is critical to assess the risk-benefit ratio of any ...
F. Chebib, V. Torres
semanticscholar   +1 more source

Polycystic Kidney Disease

Comprehensive Physiology, 2017
ABSTRACTRenal cysts, which arise from renal tubules, can be seen in a variety of hereditary and nonhereditary entities. Common mechanisms associated with renal cyst formation include increased cell proliferation, epithelial fluid secretion, and extracellular matrix remodeling.
Benjamin D. Cowley, Joseph Ghata
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Prescribed Water Intake in Autosomal Dominant Polycystic Kidney Disease

NEJM Evidence, 2021
Prescribed Water Intake in Autosomal Dominant Polycystic Kidney Disease The effect of increased water intake on kidney cyst growth in patients with polycystic kidney disease was compared for two groups randomly assigned to either prescribed or ad libitum
Gopi Rangan, Annette Wong, A. Munt, Jennifer Zhang, S. Saravanabavan, Margaret Allman-Farinelli, Sunil V. Badve, Neil Boudville, Bradley J. Erickson, Mangalee R. Fernando, Sheryl L. Foster, Adriana Gregory, I. Haloob, Carmel M. Hawley, David W. Johnson, Timothy L. Kline, Vincent W. Lee, Maureen A. Lonergan, Elaine Pascoe, A. Rangan, Simon D Roger, Kamal Sud, Vicente E. Torres, Sundareswari V. Adinarayanan, D. Harris   +24 more
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Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease

Science Translational Medicine, 2020
Pharmacological induction of NRF2 restores redox homeostasis and slows cystogenesis in mouse models of polycystic kidney disease. Antioxidants dominate ADPKD Autosomal dominant polycystic kidney disease (ADPKD) is a relatively common genetic disorder ...
Yi Lu, Yongzhan Sun, Zhiheng Liu, Yumei Lu, Xu Zhu, Bingxue Lan, Zeyun Mi, Lin Dang, Na Li, Wenlei Zhan, Lu Tan, J. Pi, H. Xiong, Lirong Zhang, Yupeng Chen   +14 more
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Polycystic Kidney Disease

New England Journal of Medicine, 2004
Polycystic kidney diseases are inherited renal disorders due mainly to mutations in genes that regulate the development and function of cells that line renal tubules. This review outlines the clinical importance of polycystic kidney diseases and discusses the cell biology and molecular mechanisms that cause the formation of hundreds of cystic lesions ...
Thomas C. Hart, Anthony J. Bleyer
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Polycystic Disease of the Kidneys

Annals of Internal Medicine, 1928
Excerpt Although polycystic degeneration of the kidneys cannot be looked upon a rare disease, it may be regarded as relatively uncommon.
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