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Polycystic Kidney Disease [PDF]
The Journal of Clinical Hypertension, 2005 Polycystic kidney disease, an inherited systemic disorder, is characterized by the development of multiple cysts in the kidneys and other organs. Patients can present at any age, but more often come to clinical attention (unless there is a family history) after age 30. Patients who are diagnosed before age 30 have a worse renal survival.
Pamela J, Fall, L Michael, Prisant
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Predictors and outcomes of laparoscopic nephrectomy in autosomal dominant polycystic kidney disease [PDF]
Investigative and Clinical Urology, 2018 Purpose: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, and 20% of patients eventually require nephrectomies due to compressive symptoms or renal-related complications. Traditionally, nephrectomies were
Kenneth Chen +5 more
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Polycystic Kidney Disease Drug Development: A Conference Report
Kidney Medicine, 2023 Autosomal dominant polycystic kidney disease (ADPKD) is part of a spectrum of inherited diseases that also includes autosomal recessive polycystic kidney disease, autosomal dominant polycystic liver disease, and an expanding group of recessively ...
Max C. Liebau +4 more
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Fetal polycystic kidney disease: Pathological overview
Journal of the Scientific Society, 2013 Polycystic kidney disease is a rare developmental anomaly inherited as autosomal dominant or autosomal recessive. It is characterized by cystic dilatation of the collecting ducts frequently associated with hepatic involvement and progression to renal ...
Sunita B Patil +3 more
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Feline Polycystic Kidney Disease: An Update
Veterinary Sciences, 2021 Polycystic kidney disease (PKD) is a disease that affects felines and other mammals, such as humans. The common name is autosomal dominant polycystic kidney disease (ADPKD) and causes a progressive development of fluid-filled cysts in the kidney and ...
Lorie Schirrer +2 more
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Phase Separation in Kidney Diseases: Autosomal Dominant Polycystic Kidney Disease and Beyond
Kidney Diseases, 2023 Background: The formation of biomolecular condensates via phase separation has emerged as a fundamental principle underlying the spatiotemporal coordination of biological activities in cells.
Lirong Zhang +4 more
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Femoral Neuropathy Secondary to Autosomal Dominant Polycystic Kidney Disease: A Case Report [PDF]
Annals of Rehabilitation Medicine, 2018 Compressive femoral neuropathy is a disabling condition accompanied by difficulty in hip flexion and knee extension. It may result from retroperitoneal hematoma or bleeding, or from complications associated with pelvic, hip surgery, and renal transplants.
Jeehyun Yoo +5 more
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Emerging Therapies for Childhood Polycystic Kidney Disease
Frontiers in Pediatrics, 2017 Cystic kidney diseases comprise a varied collection of hereditary disorders, where renal cysts comprise a major element of their pleiotropic phenotype.
William E. Sweeney, Ellis D. Avner
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Gene therapy for pediatric genetic kidney diseases
Pediatric Discovery, 2023 Genetic kidney disease is the main cause of chronic kidney disease in children. While the pathogenic genes associated with most genetic kidney diseases have been identified, the underlying mechanisms of disease initiation remain ambiguous, and effective ...
Yi Lu +4 more
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Beyond polycystic kidney disease [PDF]
BMJ Case Reports, 2017 Tuberous sclerosis(TS) is an autosomal dominant disease caused by mutations inTSC1andTSC2genes.TSC2gene is located in chromosome 16p13.3, adjacent toPKD1gene, responsible for the autosomal dominant polycystic kidney disease. In a rare subgroup of patients, the presence of a deletion which simultaneously affects theTSC2andPKD1genes has been confirmed ...
Santos, SF +3 more
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