Results 31 to 40 of about 34,123 (218)
Emerging Therapies for Childhood Polycystic Kidney Disease
Frontiers in Pediatrics, 2017 Cystic kidney diseases comprise a varied collection of hereditary disorders, where renal cysts comprise a major element of their pleiotropic phenotype.
William E. Sweeney, Ellis D. Avner
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Exploring the Spectrum of Kidney Ciliopathies
Diagnostics, 2020 Ciliopathies are a group of multi-organ diseases caused by the disruption of the primary cilium. This event leads to a variety of kidney disorders, including nephronophthisis, renal cystic dysplasia, and renal cell carcinoma (RCC).
Matteo Santoni +7 more
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Gene therapy for pediatric genetic kidney diseases
Pediatric Discovery, 2023 Genetic kidney disease is the main cause of chronic kidney disease in children. While the pathogenic genes associated with most genetic kidney diseases have been identified, the underlying mechanisms of disease initiation remain ambiguous, and effective ...
Yi Lu +4 more
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Beyond polycystic kidney disease [PDF]
BMJ Case Reports, 2017 Tuberous sclerosis(TS) is an autosomal dominant disease caused by mutations inTSC1andTSC2genes.TSC2gene is located in chromosome 16p13.3, adjacent toPKD1gene, responsible for the autosomal dominant polycystic kidney disease. In a rare subgroup of patients, the presence of a deletion which simultaneously affects theTSC2andPKD1genes has been confirmed ...
Santos, SF +3 more
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MicroRNAs and Polycystic Kidney Disease [PDF]
Drug Discovery Today: Disease Models, 2013 Polycystic kidney disease (PKD), the most common genetic cause of chronic renal failure, is characterized by the presence of numerous fluid-filled cysts in renal parenchyma. Despite recent progress, no FDA-approved therapy is available to retard cyst growth.
Lama, Noureddine +2 more
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Venous Thromboembolism in Kidney Diseases and Genetic Predisposition
Kidney Diseases, 2022 Background: Many renal diseases have been associated with profound clinical effects on thrombosis. To our knowledge, patients with nephrotic syndrome (NS) and chronic kidney disease (CKD) display an elevated risk of vein thrombosis, which is among the ...
Tingting Wu, Liang V. Tang, Yu Hu
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Cystic Kidney Diseases From the Adult Nephrologist’s Point of View
Frontiers in Pediatrics, 2018 Cystic kidney diseases affect patients of all age groups with the onset spanning from prenatal disease to late adulthood. Autosomal-dominant polycystic kidney disease (ADPKD) is by far the most common renal cystic disease.
Roman-Ulrich Müller, Thomas Benzing
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Renal cell carcinoma in autosomal dominant polycystic kidney disease: A case report
Radiology Case Reports, 2023 Autosomal dominant polycystic kidney disease (ADPKD) is one of the congenital cystic renal diseases with the highest incidence. ADPKD was suspected of being a risk factor for the emergence of RCC.
Gullyawan Rooseno +3 more
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Expert-level segmentation using deep learning for volumetry of polycystic kidney and liver [PDF]
Investigative and Clinical Urology, 2020 Purpose: Volumetry is used in polycystic kidney and liver diseases (PKLDs), including autosomal dominant polycystic kidney disease (ADPKD), to assess disease progression and drug efficiency.
Tae Young Shin +17 more
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Extracellular vesicles in kidneys and their clinical potential in renal diseases [PDF]
Kidney Research and Clinical Practice, 2021 Extracellular vesicles (EVs), such as exosomes and microvesicles, are cell-derived lipid bilayer membrane particles, which deliver information from host cells to recipient cells.
Sul A Lee, Chulhee Choi, Tae-Hyun Yoo
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