Results 61 to 70 of about 62,795 (319)
To investigate the diagnostic accuracy of delta middle cerebral artery peak systolic velocity (MCA‐PSV) > 0.5 multiples of the median (MoM) and compare its predictive value with that of the current MCA‐PSV cut‐off values of > 1.5 MoM in the donor and
L. Tollenaar+6 more
semanticscholar +1 more source
Polycythemia and pulmonary hypertension are two human diseases for which better therapies are needed. Upregulation of hypoxia inducible factor2α (HIF2α) and its target genes, erythropoietin (EPO) and endothelin-1 causes polycythemia and pulmonary ...
M. Ghosh+6 more
semanticscholar +1 more source
Summary This case report focuses on a 71-year old patient affected by unknown dyspnea and erythrocytosis referred by his general practitioner to our center for specialist advice after a hematological examination had excluded polycythemia vera on grounds ...
Zito Luca+6 more
doaj +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Targeted deep sequencing in polycythemia vera and essential thrombocythemia.
Polycythemia vera (PV) is characterized by JAK2 and essential thrombocythemia (ET) by JAK2, calreticulin (CALR), and myeloproliferative leukemia virus oncogene (MPL) mutations; we describe the occurrence and prognostic relevance of DNA sequence variants ...
A. Tefferi+15 more
semanticscholar +1 more source
Key challenges in diagnosing anemia in high‐altitude populations include variability in hemoglobin (Hb) concentration, associated pathological conditions, altitude‐induced plasma volume changes, and environmental factors such as contamination and nutrition.
Ayoub Boulares+11 more
wiley +1 more source
Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. [PDF]
In this study, because excessive polycythemia is a predominant trait in some high-altitude dwellers (chronic mountain sickness [CMS] or Monge's disease) but not others living at the same altitude in the Andes, we took advantage of this human experiment ...
Appenzeller, Otto+9 more
core
Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms [PDF]
Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,
Aranaz, P.+99 more
core +5 more sources
Sheep femoral artery occlusion is well tolerated and does not result in ischemia
Left femoral artery occlusion (yellow arrows) can be seen shortly after the lateral femoral circumflex artery origin, with distal arterial reconstitution. Sheep with femoral artery occlusion showed no change in pain scores nor mobility, thus making them an appropriate model for novel small diameter femoral artery graft studies. Abstract Objective Sheep
Timothy Shiraev+10 more
wiley +1 more source
ERYTHROPOIESIS REACTION TO TUMOR GROWTH IN LUNG CANCER PATIENTS
Background. In addition to the transport of oxygen in tissues, erythrocytes participate in maintaining homeostasis therefore their qualitative and quantitative characterization may reflect a number of changes occurring in the body.
Y. A. Ragulin+8 more
doaj +1 more source