Results 81 to 90 of about 46,034 (246)

Janus kinase inhibitors after ruxolitinib failure in myelofibrosis: A systematic review and pooled analysis of phase 3 efficacy and integrated safety across clinical trials and real‐world evidence

British Journal of Haematology, EarlyView.
Summary Ruxolitinib remains first‐line standard of care for symptomatic myelofibrosis, but resistance/intolerance develops in most patients. Three Janus kinase inhibitors (JAKis) have entered the post‐ruxolitinib space via distinct pivotal trials. We systematically searched prospective trials evaluating JAKi in refractory adults with myelofibrosis ...
Andrea Duminuco, Patrick Harrington, Elena Torre, Hillary Catellani, Novella Pugliese, Matteo Pacilli, Annalisa Santisi, Arianna Sbriglione, Giuseppe A. Palumbo   +8 more
wiley   +1 more source

Hematology and Heights – A Concern for People Living at High Altitude

Current Medical Issues
Background: Hemoglobin (Hb) values are higher in people living at an altitude as compared to inhabitants living at sea level, therefore, to define anemia and polycythemia based on Hb cutoffs may be different in both areas.
Abraham Susan Ancy, Dave Gautam Rutvi, Mammen John Joy, Yadav K Bijesh, Thomas Jason   +4 more
doaj   +1 more source

Estimated pulse wave velocity as a marker of major adverse cardiovascular events in essential thrombocythaemia and polycythaemia vera

British Journal of Haematology, EarlyView.
In patients with essential thrombocythaemia or polycythaemia vera, higher estimated pulse wave velocity (ePWV) was independently associated with major adverse cardiovascular events, while its relationship with overall survival was largely age‐driven.
Alessandro Costa, Olga Mulas, Federica Pilo, Eleonora Atzeni, Martina Pettinau, Daniela Mantovani, Giovanni Caocci   +6 more
wiley   +1 more source

Characterization of primary and secondary polycythemia among Palestinian blood donors in the West bank

Scientific Reports
Polycythemia is a hematological condition characterized by an elevated red blood cell (RBC) mass that exceeds the normal range for a specific age and gender; it can be classified as either primary or secondary. This study aimed to estimate the prevalence
Gana Odeh, Mohammed Alili, Roa Hamshari, Ahmad Saabna, Rami Zagha, Mahmoud Draidi, Safa’ Bushnaq, Suheir Ereqat, Basma Damiri   +8 more
doaj   +1 more source

Oral Idasanutlin in Patients with Polycythemia Vera.

Blood, 2019
A limited number of drugs are available to treat patients with polycythemia vera (PV) and essential thrombocythemia (ET). We attempted to identify alternative agents that may target abnormalities within malignant hematopoietic stem and progenitor cells ...
J. Mascarenhas, Min Lu, H. Kosiorek, E. Virtgaym, Lijuan Xia, L. Sandy, R. Mesa, B. Petersen, N. Farnoud, V. Najfeld, R. Rampal, A. Dueck, R. Hoffman   +12 more
semanticscholar   +1 more source

Compound‐Heterozygous PLVAP Missense Variants Associated With Attenuated Protein‐Losing Enteropathy (DIAR10)

Clinical Genetics, EarlyView.
A three‐year‐old girl with attenuated protein‐losing enteropathy carried compound‐heterozygous missense PLVAP variants inherited from unaffected non‐consanguineous parents. The case supports residual PLVAP function in missense‐associated DIAR10 and expands its genetic and clinical spectrum.
Jana Zídková, Dagmar Procházková, Petra Konečná, Kamila Réblová, Tereza Kramářová, Johana Kopčilová, Magdaléna Soukup Vodičková, Romana Borská, Lenka Fajkusová   +8 more
wiley   +1 more source

Clonal analyses reveal associations of JAK2V617F homozygosity with hematologic features, age and gender in polycythemia vera and essential thrombocythemia

Haematologica, 2013
Subclones homozygous for JAK2V617F are more common and larger in patients with polycythemia vera compared to essential thrombocythemia, but their role in determining phenotype remains unclear.
Anna L. Godfrey, Edwin Chen, Francesca Pagano, Yvonne Silber, Peter J. Campbell, Anthony R. Green   +5 more
doaj   +1 more source

Squamoid Eccrine Ductal Carcinoma: Case Series of a Rare, Potentially Aggressive Skin Cancer Associated With Immunosuppression

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Squamoid Eccrine Ductal Carcinoma (SEDC) is a rare cutaneous adenexal carcinoma first described in 1997. It has distinct biphasic features on histology which commonly result in misdiagnosis as Bowen disease or cutaneous squamous cell carcinomas (cSCC) if diagnostic skin biopsies are too superficial. This may lead to a delay in diagnosis. It is
Xiang Li Tan, Pooja Patel, Jeva Cernova, Sarah Hogan, Jason Thomson, Efthymios Hadjimichael, Sharanpal Jeetle, Dorota Markiewicz, Michael Sheaff, Nilukshi Wijesuriya, Mark Hawthorne, Graeme Moir, Matthew Stodell, Kapil Bhargava, Suchitra Chinthapalli, Catherine A. Harwood   +15 more
wiley   +1 more source

Serum transferrin receptor in polycythemia

Haematologica, 1998
We measured serum transferrin receptor (sTfR) levels in 22 patients with polycythemia vera and in 26 cases of secondary polycythemia. In our study, raised sTfR levels in both polycythemia groups were related to iron deficiency.
R Manteiga, AF Remacha, MP Sarda, J Ubeda   +3 more
doaj  

Characteristics and outcomes of patients with essential thrombocythemia or polycythemia vera diagnosed before 20 years of age: a systematic review

Haematologica, 2019
Although it is well known that myeloproliferative neoplasms occur in younger patients, few large cohorts of such patients have been reported. Thus, our knowledge about circumstances of diagnosis, outcome and treatment is limited, especially for children ...
J. Ianotto, N. Curto-Garcia, Marie Lauermanova, D. Radia, J. Kiladjian, C. Harrison   +5 more
semanticscholar   +1 more source