Dysregulated iron metabolism in polycythemia vera: etiology and consequences
Leukemia, 2018 Polycythemia vera (PV) is a chronic myeloproliferative neoplasm. Virtually all PV patients are iron deficient at presentation and/or during the course of their disease.
Yelena Z. Ginzburg +5 more
semanticscholar +1 more source
Mechanisms of haemoglobin mass expansion following heat stress
The Journal of Physiology, EarlyView.Abstract figure legend Theorised mechanisms of heat stress‐induced erythropoiesis which may facilitate the expansion of haemoglobin mass. A, acute: heat stress‐induced renal ischaemia. Redistribution of blood flow away from the kidneys to facilitate thermoregulation during heat stress could reduce renal oxygen delivery, subsequently lowering renal PO2${
Elliott J. Jenkins +4 more
wiley +1 more source
Regorafenib-related erythrocytosis in metastatic extra-gastrointestinal stromal tumor: a case report
Frontiers in OncologyIntroductionRegorafenib is an oral multi-targeted tyrosine kinase inhibitor (TKI) indicated for the treatment of various tumor types, including metastatic gastrointestinal stromal tumors (GIST), as a third-line systemic therapy.
Elena Fassi +6 more
doaj +1 more source
Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities
The Journal of Physiology, EarlyView.Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley +1 more source
Hemi-central retinal artery occlusion in young adults
Indian Journal of Ophthalmology, 2010 Amongst the clinical presentations of retinal artery occlusion, hemi-central retinal artery occlusion (Hemi-CRAO) is rarely described. This case series of four adults aged between 22 and 36 years attempts to describe the clinical profile, etiology and ...
Rishi Pukhraj +3 more
doaj
Metaplastic Carcinoma Breast in Polycythemic Octogenarian – Lessons Learnt: Case Report
Lietuvos ChirurgijaAn 80-year-old lady presented with lump Left breast of 8 months duration. Clinically was aT4b lesion, sonomammogram showed BIRADS V lesion and core needle breast biopsy features were suggestive of metaplastic carcinoma breast of adenosquamous type, ER ...
Swarup Prabhu +5 more
doaj +1 more source
Polycythemia, increased erythropoietin levels in a patient with renal lymphoma
Advanced Biomedical Research, 2014 A young male presented to our clinic with 3 months history of shortness of breathness and progressive distension of abdomen. On investigations, patient had renal failure, polycythemia and nephromegaly.
Riyaz Ahmad Bhat +3 more
doaj +1 more source
Targeted deep sequencing in polycythemia vera and essential thrombocythemia.
Blood Advances, 2016 Polycythemia vera (PV) is characterized by JAK2 and essential thrombocythemia (ET) by JAK2, calreticulin (CALR), and myeloproliferative leukemia virus oncogene (MPL) mutations; we describe the occurrence and prognostic relevance of DNA sequence variants ...
A. Tefferi +15 more
semanticscholar +1 more source
Cytoreductive therapy reduces JAK2V617F+ blood velocity and adhesion to activated endothelium
British Journal of Haematology, EarlyView.
Angelica DaSilva +8 more
wiley +1 more source
Endocrine and androgenic response to altitude training in professional cyclists
The Journal of Physiology, EarlyView.Abstract figure legend Steroidal and endocrine variables are altered during altitude training. Abstract This study investigated endocrine and steroidal blood markers in 31 male elite cyclists monitored over 7 weeks, including a 3 week altitude training camp either at 2050 m (n = 19) or 3000 m (n = 12).
Raphael Faiss +11 more
wiley +1 more source