Results 61 to 70 of about 44,617 (246)

Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals

Integrative Zoology, EarlyView.
This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley   +1 more source

What anabolic–androgenic steroids reveal about the limits of current harm reduction models

Addiction, EarlyView.
Abstract Background Harm reduction has largely been shaped by responses to psychoactive drug use where the most urgent harms are acute. These models focus on overdose, blood‐borne viruses, and rapid‐onset toxicity related harms. When applied wholesale to anabolic–androgenic steroids (AAS), they obscure the distinctive pharmacology, consumer typologies,
Timothy Piatkowski, Jason M. Nagata, Suzanne Nielsen   +2 more
wiley   +1 more source

Polycythemia Vera and Essential Thrombocythemia: A Nationwide Population-Based Study on Treatment Patterns, Vascular Complications and Survival. [PDF]

Eur J Haematol
ABSTRACT Background Polycythemia vera (PV) and essential thrombocythemia (ET) are associated with a well‐recognized increased risk of thrombotic events, bleeding, and all‐cause mortality, but the frequency of these outcomes during treatment has rarely been assessed in large cohorts.
Larsson AE, Renlund H, Andréasson B, Holmberg H, Liljeholm M, Själander A.   +5 more
europepmc   +2 more sources

Macrophages support pathological erythropoiesis in Polycythemia Vera and Beta-Thalassemia [PDF]

, 2014
Regulation of erythropoiesis is achieved by integration of distinct signals. Among these, macrophages are emerging as erythropoietin-complementary regulators of erythroid development, particularly under stress conditions. We investigated the contribution
Abdel-Wahab, Omar, Breda, Laura, Casu, Carla, Crielaard, Bart J., Ebert, Benjamin L., Gardenghi, Sara, Ghaffari, Saghi, Giardina, Patricia J., Grady, Robert W., Gupta, Ritama, Guy, Ella, Levine, Ross L., Marongiu, Maria Franca, Ramos, Pedro, Rivella, Stefano, Van Rooijen, Nico   +15 more
core   +1 more source

Testosterone Versus Clomiphene Treatment of Hypogonadism: A Retrospective Analysis in US Veterans

Andrology, EarlyView.
ABSTRACT Background Male hypogonadotropic hypogonadism is a complex condition with a multifactorial etiology. Although testosterone replacement therapy (TRT) is the only approved treatment for male hypogonadism, clomiphene citrate (CC) is often used as an off‐label treatment.
Shourya Tadisina, Elizabeth Cristiano, Thomas Wiegmann, Ken Grasing, Betty Drees, Ram Sharma, Mariana Garcia‐Touza   +6 more
wiley   +1 more source

Polycythemia at Moderate Altitude: Rethinking Screening for Polycythemia Vera

Journal of Applied Hematology
BACKGROUND: Polycythemia is a clinical condition characterized by increased red blood cell mass (RCM). With the aim to increase the sensitivity of capturing patients with polycythemia vera (PV), the hemoglobin (Hb) and hematocrit (Hct) thresholds were ...
Husain Y. Alkhaldy, Ali M. Assiri
doaj   +1 more source

Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. [PDF]

, 2017
Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and ...
Cohen IR, Douglass S, Kalas W, Mathiak M, Onita T, Zhu YH   +5 more
core   +2 more sources

Perinatal outcomes following single intrauterine death in monochorionic twin pregnancies complicated by twin anemia polycythemia sequence: Systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
The aim of this systematic review was to report perinatal outcomes in monochorionic diamniotic (MCDA) twin pregnancies complicated by twin anemia polycythemia sequence (TAPS) after single intrauterine fetal death (IUFD). Abstract Introduction Most of the studies reporting the outcome of the surviving twin after single intra‐uterine fetal death (sIUFD ...
Marina Piergianni, Asma Khalil, Giuseppe Rizzo, Ilenia Mappa, Lorenza Della Valle, Hiba J. Mustafa, Alberto Galindo, Alireza A. Shamshisaz, Francesco D'Antonio   +8 more
wiley   +1 more source

Polycythemia in Nephrotic Syndrome

Indian Journal of Kidney Diseases
The association of polycythemia with kidney diseases such as adult polycystic kidney disease, kidney tumors, and renal artery stenosis is well known. However, polycythemia associated with nephrotic syndrome (NS) is rarely seen and documented.
Anagha Auradkar, Sandhya Suresh, Ramprasad Elumalai   +2 more
doaj   +1 more source

The aging male: investigation, treatment and monitoring of late-onset hypogonadism in males [PDF]

, 2006
Androgen deficiency in the aging male has become a topic of increasing interest and debate throughout the world. The demographics clearly demonstrate the increasing percentage of the population that is in the older age groups.
Behre, Hermann M., Gooren, L. J., Kaufman, J. M., Legros, J. J., Lunenfeld, Bruno, Morley, John E., Nieschlag, Eberhard, Schulman, C., Swerdloff, Ronald, Wang, C., Weidner, W., Wu, F. C. W.   +11 more
core