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Hepcidin mimetics in polycythemia vera: resolving the irony of iron deficiency and erythrocytosis
Current opinion in hematology, 2022Purpose of review Development of hepcidin therapeutics has been a ground-breaking discovery in restoring iron homeostasis in several haematological disorders.
S. Handa +3 more
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Hematology/Oncology Clinics of North America, 2003
The differential diagnosis of an elevated hematocrit and the criteria for the diagnosis of polycythemia vera present little or no problem; however, there is not a consensus on therapy. Spivak likened this to a conundrum--"an intricate and difficult problem." Nonetheless, it can be argued that on the basis of the following criteria--life expectancy, the
Nathanial, Berlin, Nathanial I, Berlin
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The differential diagnosis of an elevated hematocrit and the criteria for the diagnosis of polycythemia vera present little or no problem; however, there is not a consensus on therapy. Spivak likened this to a conundrum--"an intricate and difficult problem." Nonetheless, it can be argued that on the basis of the following criteria--life expectancy, the
Nathanial, Berlin, Nathanial I, Berlin
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Internal and Emergency Medicine, 2010
The diagnostic approach to a patient with polycythemia has been greatly simplified by the introduction of new genetic testing in addition to traditional tests, such as measurement of red cell mass and serum erythropoietin (Epo) level. Clonal erythrocytosis, which is the diagnostic feature of polycythemia vera (PV), is almost always associated with a ...
Raffaele, Landolfi +3 more
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The diagnostic approach to a patient with polycythemia has been greatly simplified by the introduction of new genetic testing in addition to traditional tests, such as measurement of red cell mass and serum erythropoietin (Epo) level. Clonal erythrocytosis, which is the diagnostic feature of polycythemia vera (PV), is almost always associated with a ...
Raffaele, Landolfi +3 more
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Annals of Internal Medicine, 1964
Excerpt It is generally considered that the demonstration of arterial oxygen unsaturation in a patient with polycythemia indicates a secondary rather than a primary cause for the increase in red ce...
L. G. Israels +3 more
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Excerpt It is generally considered that the demonstration of arterial oxygen unsaturation in a patient with polycythemia indicates a secondary rather than a primary cause for the increase in red ce...
L. G. Israels +3 more
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Polycythemia Vera in Nonagenarian [PDF]
JAMA: The Journal of the American Medical Association, 1974 POLYCYTHEMIA vera is a disease of unknown origin, characterized by insidious onset, chronic course, and increase in the number of red blood cells (RBC) and total blood volume. 1 All of the patients reported so far in various series 2-5 have been less than 80 years of age. We recently encountered a 96-year-old white woman with polycythemia vera. Report
Shivaji R. Gunale, Leo Zelkowitz
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Journal of the American Academy of Nurse Practitioners, 1999
Although no cure exists for PV, treatment can prolong lives and enhance the quality-of-life for patients affected by this condition (Talarico, 1998). The insidious onset may make diagnosis difficult, but PV should be suspected when any patient presents with an elevated hematocrit.
Lorna Schumann, Kerri Lantz Petersen
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Although no cure exists for PV, treatment can prolong lives and enhance the quality-of-life for patients affected by this condition (Talarico, 1998). The insidious onset may make diagnosis difficult, but PV should be suspected when any patient presents with an elevated hematocrit.
Lorna Schumann, Kerri Lantz Petersen
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New England Journal of Medicine, 1963
THE course of polycythemia vera is complicated by hemorrhagic and thromboembolic phenomena of varying severity occurring in about a third of the cases. These complications have been ascribed to the hypervolemia and increased red-cell mass, with resultant sluggish blood flow, capillary distention with poor retractability, thrombocytosis and a complex ...
Louis R. Wasserman, Harriet S. Gilbert
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THE course of polycythemia vera is complicated by hemorrhagic and thromboembolic phenomena of varying severity occurring in about a third of the cases. These complications have been ascribed to the hypervolemia and increased red-cell mass, with resultant sluggish blood flow, capillary distention with poor retractability, thrombocytosis and a complex ...
Louis R. Wasserman, Harriet S. Gilbert
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Current Treatment Options in Oncology, 2018
Polycythemia vera (PV) is the most common myeloproliferative neoplasm (MPN), the ultimate phenotype of the JAK2 V1617F mutation, the MPN with the highest incidence of thromboembolic complications, which usually occur early in the course of the disease, and the only MPN in which erythrocytosis occurs. The classical presentation of PV is characterized by
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Polycythemia vera (PV) is the most common myeloproliferative neoplasm (MPN), the ultimate phenotype of the JAK2 V1617F mutation, the MPN with the highest incidence of thromboembolic complications, which usually occur early in the course of the disease, and the only MPN in which erythrocytosis occurs. The classical presentation of PV is characterized by
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Disease-a-Month, 1992
Polycythemia vera (PV) is one of the myeloproliferative diseases, and, as such, is an example of clonal hematopoiesis. The progeny of a single, abnormal, hematopoietic stem cell gain a growth advantage over their normal counterparts resulting in overproduction of red cells generally accompanied by overproduction of granulocytes and platelets as well ...
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Polycythemia vera (PV) is one of the myeloproliferative diseases, and, as such, is an example of clonal hematopoiesis. The progeny of a single, abnormal, hematopoietic stem cell gain a growth advantage over their normal counterparts resulting in overproduction of red cells generally accompanied by overproduction of granulocytes and platelets as well ...
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The Hypercoagulability of Polycythemia Vera
Hospital Practice, 1993Thrombosis is the most common cause of death in patients with this myeloproliferative syndrome. Phlebotomy, hydroxyurea, and antiplatelet agents are the mainstays of therapy but may not stave off a lethal embolism.
W, Fields, N J, Freeman
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