Results 41 to 50 of about 287,802 (318)

Persistent leukocytosis in polycythemia vera is associated with disease evolution but not thrombosis.

Blood, 2020
There are unresolved questions regarding the association between persistent leukocytosis and risk of thrombosis and disease evolution in polycythemia vera (PV), as much of the published literature on the topic does not appropriately utilize repeated ...
L. Ronner, N. Podoltsev, J. Gotlib, M. Heaney, A. Kuykendall, C. O'Connell, J. Shammo, Angela G. Fleischman, R. Scherber, R. Mesa, A. Yacoub, C. Perkins, S. Meckstroth, Lindsey Behlman, M. Chiaramonte, M. Salehi, Kimia Ziadkhanpour, Hellen Nguyen, Olivia Siwoski, A. Hung, M. Janania Martinez, Jenny Nguyen, Sagar V. Patel, R. Kollipara, Ami Dave, M. Randall, Mike Grant, M. Harrison, Paola Fernandez Soto, D. Tremblay, R. Hoffman, E. Moshier, J. Mascarenhas   +32 more
semanticscholar   +1 more source

New Perspectives on Polycythemia Vera: From Diagnosis to Therapy

International Journal of Molecular Sciences, 2020
Polycythemia vera (PV) is mainly characterized by elevated blood cell counts, thrombotic as well as hemorrhagic predisposition, a variety of symptoms, and cumulative risks of fibrotic progression and/or leukemic evolution over time.
A. Iurlo, D. Cattaneo, C. Bucelli, L. Baldini   +3 more
semanticscholar   +1 more source

Givinostat: an emerging treatment for polycythemia vera

Expert Opinion on Investigational Drugs, 2020
Introduction Polycythemia vera (PV), a Philadelphia chromosome-negative myeloproliferative neoplasm, is characterized by panmyelosis, pancytosis, and a JAK2 mutation.
H. Chifotides, P. Bose, S. Verstovsek
semanticscholar   +1 more source

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms [PDF]

, 2015
Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,
Aranaz, P., Aranaz, P., Bandinelli, S., Bandinelli, S., Barosi, G., Barosi, G., Baxter, E.J., Baxter, E.J., Callaway, A., Callaway, A., Campbell P., Campbell P., Cazzola, M., Cazzola, M., Chase, A., Chase, A., Chen, E., Chen, E., Cross N.C., Cross N.C., Dohner, K., Dohner, K., Duncombe, A.S., Duncombe, A.S., Evans, P., Evans, P., Ewing, J., Ewing, J., Gale, R.E., Gale, R.E., Giannopoulos, A., Giannopoulos, A., Gisslinger, H., Gisslinger, H., Godfrey, A.L., Godfrey, A.L., Grallert, H., Grallert, H., Green, A.R., Green, A.R., Griffiths, M., Griffiths, M., Guglielmelli, P., Guglielmelli, P., Haferlach, T., Haferlach, T., Harrison, C., Harrison, C., Harutyunyan, A.S., Harutyunyan, A.S., Jack, A., Jack, A., Jones, A.V., Jones, A.V., Kralovics, R., Kralovics, R., Leung, W., Leung, W., Lin, F., Lin, F., Maclean, C., Maclean, C., Mannarelli, C., Mannarelli, C., Mead, A.J., Mead, A.J., Nangalia, J., Nangalia, J., Oscier, D., Oscier, D., Pieri, L., Pieri, L., Reiter, A., Reiter, A., Schnittger, S., Schnittger, S., Schuh, A., Schuh, A., Short, M., Short, M., Stegelmann, F., Stegelmann, F., Strauch, K., Strauch, K., Tanaka, T., Tanaka, T., Tapper, W., Tapper, W., Vannucchi, A., Vannucchi, A., Waghorn, K., Waghorn, K., Wallis, L., Wallis, L., Ward, D., Ward, D., White, H.E., White, H.E., Zoi, K., Zoi, K.   +99 more
core   +5 more sources

Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part Phase Ib/II study

Leukemia, 2020
Rambaldi, A., Iurlo, A., Vannucchi, A. M., Noble, R., von Bubnoff, N., Guarini, A., Martino, B., Pezzutto, A., Carli, G., De Muro, M., Luciani, S., McMullin, M. F., Cambier, N., Marolleau, J-P., Mesa, R. A., Tibes, R., Pancrazzi, A., Gesullo, F., Bettica,
A. Rambaldi, A. Iurlo, A. Vannucchi, R. Noble, N. von Bubnoff, A. Guarini, B. Martino, A. Pezzutto, G. Carli, M. De muro, Stefania Luciani, M. McMullin, N. Cambier, J. Marolleau, R. Mesa, R. Tibes, A. Pancrazzi, F. Gesullo, P. Bettica, S. Manzoni, Silvia Di Tollo   +20 more
semanticscholar   +1 more source

The JAK2V617 mutation induces constitutive activation and agonist hypersensitivity in basophils from patients with polycythemia vera

Haematologica, 2009
Background The JAK2V617F mutation has been associated with constitutive and enhanced activation of neutrophils, while no information is available concerning other leukocyte subtypes.Design and Methods We evaluated correlations between JAK2V617F mutation ...
Lisa Pieri, Costanza Bogani, Paola Guglielmelli, Maria Zingariello, Rosa Alba Rana, Niccolò Bartalucci, Alberto Bosi, Alessandro M. Vannucchi   +7 more
doaj   +1 more source

Macrophages support pathological erythropoiesis in Polycythemia Vera and Beta-Thalassemia [PDF]

, 2014
Regulation of erythropoiesis is achieved by integration of distinct signals. Among these, macrophages are emerging as erythropoietin-complementary regulators of erythroid development, particularly under stress conditions. We investigated the contribution
Abdel-Wahab, Omar, Breda, Laura, Casu, Carla, Crielaard, Bart J., Ebert, Benjamin L., Gardenghi, Sara, Ghaffari, Saghi, Giardina, Patricia J., Grady, Robert W., Gupta, Ritama, Guy, Ella, Levine, Ross L., Marongiu, Maria Franca, Ramos, Pedro, Rivella, Stefano, Van Rooijen, Nico   +15 more
core   +1 more source

Neutropenia caused by hairy cell leukemia in a patient with myelofibrosis secondary to polycythemia vera: a case report

Journal of Medical Case Reports, 2018
Background Polycythemia vera is a myeloproliferative disease that sometimes evolves to myelofibrosis, causing splenomegaly and neutropenia. In this case report, we describe a patient with polycythemia vera and unexplained neutropenia who later turned out
Andreas Hanssønn Habberstad, Hoa Thi Tuyet Tran, Ulla Randen, Signe Spetalen, Ingunn Dybedal, Geir E. Tjønnfjord, Anders Erik Astrup Dahm   +6 more
doaj   +1 more source

Preleukemia: hematological disorders prior to onset of leukemia [PDF]

, 1975
Published data on Japanese leukemia patients with a preleukemic hematological disorder were assessed. The reexamined cases were from the "Japona Centra Revuo Medicina" reported during the period from 1952 to 1971.
Hiraki, Kiyoshi, Kitajima, Koichi, Mikochi, Hiroshi, Nakanishi, Toshio, Sakato, Junya, Takahashi, Isao   +5 more
core   +1 more source

Concurrent Polycythemia Vera with Newly Diagnosed Multiple Myeloma: Case Report and Literature Review

Journal of Inflammation Research, 2023
Jing Yuan, Xuan Liu, Zhenzhen Wang, Liyuan Li, Fuxu Wang Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of ChinaCorrespondence: Fuxu Wang, Department of Hematology, The Second ...
Yuan J, Liu X, Wang Z, Li L, Wang F
doaj