Results 341 to 350 of about 420,886 (376)
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Optimizing investigation of suspected allergy to polyethylene glycols.
Journal of Allergy and Clinical Immunology, 2021Maria A Bruusgaard-Mouritsen +4 more
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Toxicity of topical polyethylene glycol
Toxicology and Applied Pharmacology, 1982Abstract An animal model was developed to study the potential toxicity resulting from repeated, topical applications of a polyethylene glycol-based antimicrobial cream. Applications of this cream to open wounds in rabbits produced the same syndrome observed in the burn patients treated with this agent.
Richard F. Edlich +5 more
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Precipitation of collagens by polyethylene glycols
Analytical Biochemistry, 1984Types I, II, and III collagens are readily precipitated at neutral pH by polyethylene glycols (PEG). As the molecular weight fraction of the polyethylene glycols increases, they become more effective as precipitants on a weight basis. The amount of PEG required for precipitation depends on the pH, the ionic strength, and the nature of the buffer or ...
John F. Bateman +2 more
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Use of Polyethylene Glycol in Biology
Nature, 1961IN a recent paper, I. Mackenzie Lamb1 directed attention to the use of polyethylene glycol (‘Carbowax’) for the permanent preservation of algal material for microscopic study. He shows that it is practicable to preserve algae in the dry state embedded in polyethylene glycol and mounted on cards. When a portion is required for study, part of the card is
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The Immunogenicity of Polyethylene Glycol: Facts and Fiction
Pharmaceutical Research, 2013An increasing number of pegylated therapeutic proteins and drug targeting compounds are being introduced in the clinic. Pegylation is intended to increase circulation time and to reduce an immunogenic response. Recently however a number of publications have appeared claiming that the polyethylene glycol (PEG) moiety of these products in itself may be ...
Huub Schellekens +2 more
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The absorption and excretion of the solid polyethylene glycols; (carbowax compounds).
Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1947The extent of gastrointestinal absorption of several solid polyethylene glycols including those designated as “Carbowax” compounds 1000, 1540, 4000, and 6000 has been determined following their administration to rats and to humans.
C. B. Shaffer, F. Critchfield
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The chronic oral toxicology of the polyethylene glycols.
Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1955Polyethylene glycols were fed in the diet to rats for two years and to dogs for one year.Apparently a compound with a mean molecular weight of 6,000 is definitely less toxicby mouth than those of lower molecular weights.This work supports the view that ...
H. F. Smyth, C. P. Carpenter, C. S. Weil
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SENSITIZATION TO POLYETHYLENE GLYCOLS (CARBOWAXES®)
Archives of Dermatology, 1950THE POLYETHYLENE glycols are condensation or polymerization products of ethylene glycol of relatively high molecular weights. The heavier and more solid of these have been called carbowaxes.® The polyethylene glycols commonly used range from polyethylene glycol 400, a thick liquid of a consistency similar to glycerin, through carbowax® 1500, an ...
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Accelerated Clearance of Polyethylene Glycol-Modified Proteins by Anti-Polyethylene Glycol IgM
Bioconjugate Chemistry, 1999Tumor therapy by the preferential activation of a prodrug at tumor cells targeted with an antibody-enzyme conjugate may allow improved treatment efficacy with reduced side effects. We examined antibody-mediated clearance of poly(ethylene glycol)-modified beta-glucuronidase (betaG-sPEG) as a method to reduce serum concentrations of enzyme and minimize ...
Pin-Yi Wu +4 more
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Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1947
Results of administering oral doses of high molecular weight polyethylene glycols to rats over a two‐year period are reported. The single dose toxicity for several of these compounds by intraperitoneal administration to rats and intravenously to rabbits ...
H. F. Smyth +2 more
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Results of administering oral doses of high molecular weight polyethylene glycols to rats over a two‐year period are reported. The single dose toxicity for several of these compounds by intraperitoneal administration to rats and intravenously to rabbits ...
H. F. Smyth +2 more
semanticscholar +1 more source