Results 81 to 90 of about 32,092 (318)

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Tunable Thermoshrinkable Hydrogels for 4D Fabrication of Cell‐Seeded Channels

Advanced Functional Materials, EarlyView.
A thermoresponsive polymer with methacrylate groups for photo‐cross‐linking, based on polyethylene glycol, N‐isopropylacrylamide, and 2‐hydroxyethyl acrylate is synthetized to yield hydrogels that shrink upon temperature increase. The new polymer enables the fabrication of cell‐laden perfusable channels with diameters below 200 µm by combining ...
Greta Di Marco, Marc Falandt, Myriam Neumann, Martina Viola, Thibault Sampon, Marta G. Valverde, Anne Metje van Genderen, Silvia M. Mihaila, Cornelus F. van Nostrum, Bas G. P. van Ravensteijn, Riccardo Levato, Rosalinde Masereeuw, Tina Vermonden   +12 more
wiley   +1 more source

Ultrasoft Iontronics: Stretchable Diodes Enabled by Ionically Conductive Bottlebrush Elastomers

Advanced Functional Materials, EarlyView.
This work introduces a solvent‐free, ultrasoft, and stretchable ionic diode based on oppositely charged bottlebrush elastomers (BBEs). The BBE diode exhibits an ultralow Young's modulus (<23 kPa), a high rectification ratio of 46, and stretchability over 400%.
Xia Wu, Pengfei Xu, Zefang Zhang, Qi Yang, Xi Huang, Peng Pan, Xinyu Liu   +6 more
wiley   +1 more source

Study of the Stability of a Viscous Solution of Naftifin Hydrochloride with a Combination of Polyethylene Glycols for External Use

Разработка и регистрация лекарственных средств, 2020
Introduction. An innovative antifungal viscous solution based on naftifine hydrochloride with a combination of polyethylene glycols (PEG) was developed in the laboratory of Sechenov University. The developed preparation intended for external use.
S. I. Kosenkova, I. I. Krasnyuk, I. I. Krasnyuk (jr.), A. V. Belyatskaya, O. I. Stepanova, E. V. Mazyarkin, T. V. Korochkina, Yu. Ya. Kharitonov   +7 more
doaj   +1 more source

Precision Photothermal Therapy at Mild Temperature: NIR‐II Imaging‐Guided, H2O2‐Responsive Stealth Nanobomb

Advanced Healthcare Materials, EarlyView.
The new generation nanobomb, termed the stealth nanobomb, is fabricated through self‐assembly using a polymeric carbon monoxide carrier (PLGA(CO)), small molecule near‐infrared‐active agents (2TT‐OC46B), and phospholipid polyethylene glycol (DSPE‐mPEG2000). The stealth nanobomb can circulate in the bloodstream and specifically target pancreatic cancer,
Gongcheng Ma, Qihang Ding, Yue Wang, Zhiwei Zhang, Yuding Zhang, Hui Shi, Lintao Cai, Ping Gong, Pengfei Zhang, Zhen Cheng, Jong Seung Kim   +10 more
wiley   +1 more source

Synthetic Chemicals as Potential Tracers of Impacts of Fracturing Fluids on Groundwater

Pollutants
Application of hydraulic fracturing to produce “unconventional” oil and gas from shale formations and other low-permeability geological units has raised concerns about the potential environmental impacts, including potential adverse effects of fracturing
Dale R. Van Stempvoort, Susan Brown, Priyantha Kulasekera, Pamela Collins   +3 more
doaj   +1 more source

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

An In Situ Curing, Shear‐Responsive Biomaterial Designed for Durable Embolization of Microvasculature

Advanced Healthcare Materials, EarlyView.
NeoCast is a next‐generation, solvent‐free, non‐adhesive liquid embolic designed for indications where deep occlusion is desired (e.g., tumors and chronic subdural hematoma). This novel agent offers ideal embolic properties: injectability, controllability, excellent visibility, and biocompatibility.
Quynh P. Pham, Jeffrey V. Groom II, Chander Sadasivan, David J. Fiorella, David C. Madoff, Lee‐Jae Guo, Michael Fornaciari, Courtney Guertin, Craig Wiltsey, Lee Core, Jonathan Merlo, William Wustenberg, Renu Virmani, Adam S. Arthur, Robert S. Langer, George M. Whitesides, Upma Sharma   +16 more
wiley   +1 more source