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Current Protocols, 2021
AbstractAs genome‐wide association studies have continued to identify loci associated with complex traits, the implications of and necessity for proper use of these findings, including prediction of disease risk, have become apparent. Many complex diseases have numerous associated loci with detectable effects implicating risk for or protection from ...
Michael D, Osterman +2 more
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AbstractAs genome‐wide association studies have continued to identify loci associated with complex traits, the implications of and necessity for proper use of these findings, including prediction of disease risk, have become apparent. Many complex diseases have numerous associated loci with detectable effects implicating risk for or protection from ...
Michael D, Osterman +2 more
openaire +2 more sources
2022
Coronary artery disease (CAD) is highly heritable. The technological advances over the past decade have enabled faster and more comprehensive genetic analysis with a simultaneous lowering of costs. This has resulted in a better understanding of the genetic determinants of atherosclerosis and CAD, and thus an increasing interest in and demand for ...
Christoffersen, Mette +1 more
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Coronary artery disease (CAD) is highly heritable. The technological advances over the past decade have enabled faster and more comprehensive genetic analysis with a simultaneous lowering of costs. This has resulted in a better understanding of the genetic determinants of atherosclerosis and CAD, and thus an increasing interest in and demand for ...
Christoffersen, Mette +1 more
openaire +2 more sources
Boosting polygenic risk scores
2022AbstractPolygenic risk scores (PRS) evaluate the individual genetic liability to a certain trait and are expected to play an increasingly important role in the field of clinical risk stratification. Most often, PRS are estimated based on summary statistics of univariate effects derived from genome-wide association studies.
Hannah Klinkhammer +4 more
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Polygene risk scores and randomized experiments
Behavioral and Brain Sciences, 2023Abstract We explore Madole & Harden's (2022) suggestion that single-nucleotide polymorphism (SNP)/trait correlations are analogous to randomized experiments and thus can be given a causal interpretation.
Lauren N. Ross +2 more
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Polygenic risk score in prostate cancer
Current Opinion in Urology, 2022Purpose of review This study was conducted in order to review the outcomes regarding polygenic risk score (PRS) in prediction of prostate cancer (PCa). With the increasing proficiency of genetic analysis, assessment of PRS for prediction of PCa has been performed in numerous studies.
Jong Jin, Oh, Sung Kyu, Hong
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Polygenic risk scores in coronary artery disease
Current Opinion in Cardiology, 2022Purpose of review Recent advances in genetics have facilitated the calculation of polygenic risk scores (PRSs) based on common genetic risk variants of coronary artery disease (CAD). Here, we provide an explanation of the genetic basis for PRSs and review recent literature investigating PRSs and the clinical utility for ...
Christiansen, Morten Krogh +2 more
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Polygenic Risk Scores in Human Disease
Clinical ChemistryAbstract Background Polygenic risk scores (PRS) are measures of genetic susceptibility to human health traits. With the advent of large data repositories combining genetic data and phenotypic information, PRS are providing valuable insights into the genetic architecture of complex diseases and are ...
Dimitri J, Maamari +2 more
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Polygenic risk scores in kidney transplantation
Current Opinion in Organ TransplantationPurpose of review Estimation of genetic risk is crucial for understanding heritable diseases but also transplant outcomes. Polygenic risk scores (PRSs) are constructed from genome-wide association studies (GWAS) summing an individual's risk alleles weighted by their effect size.
Kira, Jelencsics, Rainer, Oberbauer
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Polygenic risk scores in bipolar disorder subgroups
Journal of Affective Disorders, 2015Bipolar disorder (BD) is a genetically and clinically heterogeneous disorder. Current classifications of BD rely on clinical presentations without any validating biomarkers, making homogenous and valid subtypes warranted. This study aims at investigating whether a BD polygenic risk score (PGRS) can validate BD subtypes including diagnostic sub ...
Sofie Ragnhild, Aminoff +7 more
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