Results 111 to 120 of about 40,214 (287)

Using polygenic scores in combination with symptom rating scales to identify attention-deficit/hyperactivity disorder

BMC Psychiatry
Background The inclusion of biomarkers could improve diagnostic accuracy of attention-deficit/hyperactivity disorder (ADHD). One potential biomarker is the ADHD polygenic score (PGS), a measure of genetic liability for ADHD.
André Høberg, Berit Skretting Solberg, Tor-Arne Hegvik, Jan Haavik   +3 more
doaj   +1 more source

Polygenic Risk Score Analysis of Alzheimer's Disease in Cases without APOE4 or APOE2 Alleles [PDF]

, 2019
Valentina Escott‐Price, A. Myers, MJ Huentelman, Maryam Shoai, John Hardy   +4 more
openalex   +1 more source

Reshaping study design for faster extrapolation‐based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN–NASPGHAN position paper

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Children with inflammatory bowel diseases (IBD) have limited access to the available advanced therapies, given the lengthy gap between adult and pediatric approval. We aimed to review key hurdles for pediatric trials and recommend practical solutions.
Dan Turner, Amit Assa, Mikkel Malham, Shira Yuval Bar‐Asher, Carla Rayan, Jeffrey S. Hyams, Holm H. Uhlig, Brad Pasternak, David C. Wilson, Hilary K. Michel, Lissy de Ridder, Eric Zuckerman, Marina Aloi, Peter Szitanyi, Marla C. Dubinsky, Anne M. Griffiths, Roberto Saldana, Javier Martín‐de‐Carpi, Eytan Wine, Richard K. Russell, Jeremy Adler, Joseph Picoraro   +21 more
wiley   +1 more source

Association Between Body Mass Index and Depression/Anxiety in an East Asian Population: A Mendelian Randomization Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Obesity and psychiatric disorders are the leading causes of global morbidity. Epidemiological studies suggest a bidirectional link between higher body mass index (BMI) and mental health outcomes, but the direction of causality remains uncertain due to confounding and reverse causation. We performed a Mendelian randomization (MR) analysis using
Perl Han Lee, Szu‐Chia Chen, Chien‐Hung Lee, Jiun‐Hung Geng, Chih‐Hung Ko   +4 more
wiley   +1 more source

Polygenic risk scores [PDF]

Journal of Advanced Nursing, 2019
openaire   +3 more sources

Applications and Challenges of Digital Health in Rheumatology

iNew Medicine, EarlyView.
Xiao‐Xiao Li, Xue‐Er Cheng, Ming‐Ming Zhang, Peng Wang, Hai‐Feng Pan   +4 more
wiley   +1 more source

Towards Comprehensive Chronic Disease Control: Prevention, Early Detection, and Integrated Management

Medicine Bulletin, EarlyView.
ABSTRACT Chronic non‐communicable diseases (NCDs), including cardiovascular disease, diabetes, cancer, and chronic respiratory conditions, represent the leading causes of morbidity and mortality worldwide. This review examines comprehensive strategies across the continuum of care (from primary prevention and early screening to timely diagnosis ...
Ping Sun, Zhengwei Wan, Yuping Liu
wiley   +1 more source

Using LDpred2 to adapt polygenic risk score techniques for methylation score creation

BMC Research Notes
Objective This study sought to determine if the R package LDpred2, designed for polygenic risk score creation for genome-wide association studies using summary statistics, could be adapted for deriving DNA methylation scores from methylome-wide ...
Kristoffer Sandås, Leticia Spindola, Solveig Løkhammer, Anne-Kristin Stavrum, Ole Andreassen, Markos Tesfaye, Stéphanie Le Hellard   +6 more
doaj   +1 more source

Movement Disorders Associated with 22q11.2 Microdeletion: A Scoping Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Movement disorders have recently emerged as important neurologic manifestations of the 22q11.2 microdeletion that affects nearly one in every 2000 live births. Objective We aimed to map the existing evidence regarding the spectrum, diagnosis and treatment, and etiopathogenesis of movement disorders associated with 22q11.2 ...
Nikolai Gil D. Reyes, Daniel G. Di Luca, Connie Marras, Erik Boot, Ryan K.C. Yuen, Anthony E. Lang, Anne S. Bassett   +6 more
wiley   +1 more source

Stacked neural network for predicting polygenic risk score

Scientific Reports
In recent years, the utility of polygenic risk scores (PRS) in forecasting disease susceptibility from genome-wide association studies (GWAS) results has been widely recognised.
Sun bin Kim, Joon Ho Kang, MyeongJae Cheon, Dong Jun Kim, Byung-Chul Lee   +4 more
doaj   +1 more source