Results 111 to 120 of about 2,929,620 (353)

A polygenic risk score and age of diagnosis of COPD

European Respiratory Journal, 2022
Background Genetic susceptibility may be associated with earlier onset of chronic obstructive pulmonary disease (COPD). We hypothesised that a polygenic risk score (PRS) for COPD would be associated with earlier age of diagnosis of COPD.
Jingzhou Zhang, Hanfei Xu, D. Qiao, D. Demeo, E. Silverman, G. O'Connor, B. Hobbs, J. Dupuis, M. Cho, M. Moll   +9 more
semanticscholar   +1 more source

Problems With Using Polygenic Scores to Select Embryos

Obstetrical & Gynecological Survey, 2021
(Abstracted from N Engl J Med 2021;385:78–86) Embryo selection based on polygenic scores (ESPS) is the principle wherein one can select individualized embryos to transfer as part of in vitro fertilization based on predictions of health and other outcomes derived from genome-wide association studies (GWASs).
Peter M. Visscher, Steven E. Hyman, Steven E. Hyman, Louise Wilkins-Haug, Nancy Wang, David Cesarini, Evelynn Hammonds, Alicia R. Martin, Heidi L. Rehm, Heidi L. Rehm, David Laibson, David Laibson, Daniel J. Benjamin, Daniel J. Benjamin, Patrick Turley, Michelle N. Meyer, Benjamin M. Neale, Benjamin M. Neale   +17 more
openaire   +6 more sources

Identification of Transdiagnostic Childhood Externalizing Pathology Within an Electronic Medical Records Database and Application to the Analysis of Rare Copy Number Variation

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Externalizing traits and behaviors are broadly defined by impairments in self‐regulation and impulse control that typically begin in childhood and adolescence. Externalizing behaviors, traits, and symptoms span a range of traditional psychiatric diagnostic categories.
India A. Reddy, Lide Han, Sandra Sanchez‐Roige, Maria Niarchou, Douglas M. Ruderfer, Lea K. Davis   +5 more
wiley   +1 more source

Prostate cancer polygenic risk score and prediction of lethal prostate cancer

npj Precision Oncology, 2022
Polygenic risk scores (PRS) for prostate cancer incidence have been proposed to optimize prostate cancer screening. Prediction of lethal prostate cancer is key to any stratified screening program to avoid excessive overdiagnosis. Herein, PRS for incident
R. Klein, E. Vertosick, D. Sjoberg, D. Ulmert, Ann-Charlotte Rönn, Christel Häggström, Elin Thysell, G. Hallmans, A. Dahlin, P. Stattin, O. Melander, A. Vickers, H. Lilja   +12 more
semanticscholar   +1 more source

Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive‐Compulsive Disorder

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT A large proportion of patients undergoing cognitive behavior therapy (CBT) for obsessive‐compulsive disorder (OCD) do not respond sufficiently to treatment. Identifying predictors for change in symptom severity after treatment could inform clinical decision‐making, allow for better‐tailored interventions, and avoid treatment failure.
Julia Bäckman, John Wallert, Matthew Halvorsen, Bjorn Roelstraete, Elles de Schipper, Nora I. Strom, Thorstein Olsen Eide, Kira D. Höffler, Manuel Mattheisen, Bjarne Hansen, Gerd Kvale, Kristen Hagen, Jan Haavik, Nordic OCD and Related Disorders Consortium (NORDiC), Julia Bäckman, Long Long Chen, James J. Crowley, Elles de Schipper, Diana Pascal, Jan Haavik, Kristen Hagen, Matthew W. Halvorsen, Bjarne Hansen, Kira D. Höffler, Fredrik Johansson, Anna K. Kähler, Elinor K. Karlsson, Gerd Kvale, Paul Lichtenstein, Kerstin Lindblad‐Toh, Manuel Mattheisen, David Mataix‐Cols, Kathleen Morrill, Christian Rück, Thorstein Olsen Eide, Nora I. Strom, John Wallert, David Mataix‐Cols, Christian Rück, James J. Crowley   +39 more
wiley   +1 more source

Psychological problems, biomedical models, and stigma: A commentary on Lahey et al. (2022)

, 2022
JCPP Advances, Volume 2, Issue 4, December 2022.
Stephen P. Hinshaw
wiley   +1 more source

Penalized regression and model selection methods for polygenic scores on summary statistics.

PLoS Computational Biology, 2020
Polygenic scores quantify the genetic risk associated with a given phenotype and are widely used to predict the risk of complex diseases. There has been recent interest in developing methods to construct polygenic risk scores using summary statistic data.
Jack Pattee, Wei Pan
doaj   +1 more source

Psychoses of Epilepsy: Unravelling the Phenotypic and Genotypic Features

Annals of Neurology, EarlyView.
Objectives We analyzed the genotypic and phenotypic features of patients with psychosis of epilepsy (POE). Methods Patients with POE recruited to an epilepsy genetics research program underwent phenotyping and genetic analysis. The latter included screening for rare pathogenic variants in epilepsy genes, and polygenic risk score (PRS) calculation for ...
Genevieve Rayner, Eliza Honybun, Melanie Bahlo, Karen L. Oliver, Ingrid E. Scheffer   +4 more
wiley   +1 more source

Reading tea leaves? Polygenic scores and differences in traits among groups [PDF]

arXiv, 2019
In the past decade, Genome-Wide Association Studies (GWAS) have delivered an increasingly broad view of the genetic basis of human phenotypic variation. One of the major developments from GWAS is polygenic scores, a genetic predictor of an individual's genetic predisposition towards a trait constructed from GWAS.
arxiv  

Deep Phenotyping of Non-Alcoholic Fatty Liver Disease Patients with Genetic Factors for Insights into the Complex Disease [PDF]

arXiv, 2023
Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disorder characterized by the excessive accumulation of fat in the liver in individuals who do not consume significant amounts of alcohol, including risk factors like obesity, insulin resistance, type 2 diabetes, etc.
arxiv