Results 121 to 130 of about 1,650,847 (244)

Genetic Biomarkers in the Risk Assessment of Sudden Cardiac Events: A Personalized Approach

iNew Medicine, EarlyView.
Genetic insights into the risk assessment of sudden cardiac events. ABSTRACT Sudden cardiac events are the leading cause of death worldwide. Conventional risk stratification methods, which largely depend on clinical history, imaging, and electrocardiography, are usually inadequate for identifying high‐risk individuals, especially those without visible ...
Shrikant Verma, Sushma Verma, Mohammad Abbas, Tabrez Faruqui, Bashir Ahmad Mir, Farzana Mahdi   +5 more
wiley   +1 more source

Irritability in preschool children with attention‐deficit/hyperactivity disorder: Analysis of family environmental factors

JCPP Advances, EarlyView.
Abstract Background Irritability affects one‐third of children and adolescents with attention‐deficit/hyperactivity disorder (ADHD) and is associated with negative outcomes. The family environment plays a prominent role in the child's development, and therefore on the risk for irritability, especially during the preschool period.
Analin Ono Baraniuk, Giovanni Abrahão Salum, David Daley, Erika Mendonça de Morais, Filipe Jaeger Zabala, Luiz Eduardo de Souza, Guilherme V. Polanczyk, Luisa Shiguemi Sugaya   +7 more
wiley   +1 more source

Polygenic Risk Score in Clinical Practice: A Review

Indian Journal of Clinical Cardiology
Cardiovascular diseases continue to be the leading cause of mortality and morbidity in the world. The prevalence has been changing with time in the developing and developed world.
Karthik Tummala
doaj   +1 more source

The role of rare copy number variants in early‐onset depression

JCPP Advances, EarlyView.
Abstract Background Depression is a highly heterogeneous condition. Depression with an onset in childhood and early adolescence has a worse clinical course, is more heritable, and shows a lower genetic correlation with other depression subtypes, than does later‐onset depression.
Charlotte A. Dennison, Ida Sønderby, Miguel Garcia‐Argibay, Victoria Powell, Amy Shakeshaft, Lucy Riglin, Elliott Rees, Michael O’Donovan, Henrik Larsson, Ole Andreassen, Alexandra Havdahl, Joanna Martin, Anita Thapar   +12 more
wiley   +1 more source

Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders

JCPP Advances, EarlyView.
Abstract Background Evidence indicates substantial genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder‐specific genetic architecture and patterns of comorbidity. Methods We applied genomic structural equation modeling to genome‐wide association study summary statistics from 11 ...
Engin Keser, Wangjingyi Liao, Andrea G. Allegrini, Kaili Rimfeld, Thalia C. Eley, Robert Plomin, Margherita Malanchini   +6 more
wiley   +1 more source

Common cause versus dynamic mutualism: Insights into ADHD's common comorbidities

JCPP Advances, EarlyView.
Abstract Background Contemporary classification systems differ in their conceptualization of ADHD as either an externalizing or neurodevelopmental condition, with both perspectives promoting the common cause model as an explanation of ADHD's comorbidity.
Zheyue Peng, Ashley L. Watts
wiley   +1 more source

Stacked neural network for predicting polygenic risk score

Scientific Reports
In recent years, the utility of polygenic risk scores (PRS) in forecasting disease susceptibility from genome-wide association studies (GWAS) results has been widely recognised.
Sun bin Kim, Joon Ho Kang, MyeongJae Cheon, Dong Jun Kim, Byung-Chul Lee   +4 more
doaj   +1 more source

Shared genetics between ADHD and reading/language abilities: Genome‐wide correlations, stratified enrichment, cross‐trait association, and mendelian randomization

JCPP Advances, EarlyView.
Abstract Background Attention‐deficit/hyperactivity disorder (ADHD) and language/reading difficulties frequently co‐occur. The extent of shared genetic architecture remains incompletely defined. We investigated genome‐wide overlap between ADHD and four core skills: word reading, nonword reading, spelling, and phoneme awareness.
Jinzhu Zhao, Shi Huang, Wei Liu, Feng Wang, Hong Qian, Xiaolin Hu   +5 more
wiley   +1 more source

Multivariate genetic analyses test for the presence of a general ‘n’ factor underlying neurodevelopmental conditions

JCPP Advances, EarlyView.
Abstract Background Neurodevelopmental conditions often emerge early in life and have substantial genetic influences. There are significant genetic correlations between neurodevelopmental conditions, such as between autism spectrum disorder (Autism) and attention deficit‐hyperactivity disorder (ADHD), and they are listed together in diagnostic manuals.
Morgan James Morgan, Margherita Malanchini, Elise B. Robinson, Angelica Ronald   +3 more
wiley   +1 more source

Categories or dimensions? A critical systematic review of taxometric evidence in autism, ADHD, and language disorders

JCPP Advances, EarlyView.
Abstract Background Taxometric analysis is designed to test whether the latent structure underlying clinical conditions is categorical (taxonic) or dimensional. Despite its relevance to ongoing debates on neurodevelopmental conditions, its application to this field remains limited.
Enrico Toffalini, Margherita Calderan, Riccardo Pagan, Valentina Tobia, Edmund Sonuga‐Barke   +4 more
wiley   +1 more source