Results 141 to 150 of about 1,650,847 (244)

Joint Risk Factor Combinations with Additive Interaction Increase the Risk of Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Combined effects of multiple risk factors on incident late‐onset Parkinson's disease (PD; LOPD) remain poorly characterized. Objective The objective of this study was to quantify the impact of joint risk exposures and estimate the contribution of potentially modifiable factors to incident LOPD risk.
Andrea Quattrone, Basilio Vescio, Fulvia Arcuri, Giuseppe Chiarella, Jolanda Buonocore, Aldo Quattrone   +5 more
wiley   +1 more source

Blood pressure polygenic score, cardiorespiratory fitness and odds of dementia: the HUNT Study. [PDF]

Age Ageing
Lerfald M, Øvretveit K, Nilsen TIL, Eldholm RS, Grøtting N, Wolford BN, Selbaek G, Ernstsen L.   +7 more
europepmc   +1 more source

Ursodeoxycholic Acid and Parkinson's Disease Risk: An Emulated Target Trial in UK Electronic Health Records

Movement Disorders, EarlyView.
Abstract Background Ursodeoxycholic acid (UDCA) has shown mitochondrial and neuroprotective effects and has been proposed as a treatment for Parkinson's disease (PD). However, population‐level evidence on its effect on PD risk is lacking. Objectives To compare the risk of incident PD among UDCA initiators versus matched non‐initiators within a ...
Chengsheng Ju, Anette Schrag, Camille Carroll, Xi Xiong, James Carpenter, Oliver Bandmann, Thomas Foltynie, Li Wei   +7 more
wiley   +1 more source

α‐Synuclein Seeding Discriminates Between LRRK2 G2019S Variant Carriers with and Without Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Reliable biomarkers for Parkinson's disease (PD) pathology detection are essential for research. α‐Synuclein (aSyn) seed amplification assay (SAA) is a validated biomarker for misfolded aSyn. Objective The aim was to assess the association between aSyn SAA and LRRK2‐related PD (LRRK2‐PD) and its link to mitochondrial genetic burden.
Theresa Lüth, Carolin Gabbert, Teresa Kleinz, Christoph Much, Björn‐Hergen Laabs, Sebastian Sendel, Inke R. König, Amke Caliebe, Matthew Farrer, Brian Fiske, Cornelis Blauwendraat, Christine Klein, Joanne Trinh, Global Parkinson's Genetics Program (GP2)   +13 more
wiley   +1 more source

Genetic and non-genetic determinants of vitamin D status: a polygenic score analysis in elite athletes. [PDF]

Front Genet
Hacker S, Reichert L, Lenz C, Henne S, David F, Heilmann-Heimbach S, Zentgraf K, Krüger K.   +7 more
europepmc   +1 more source

Effect-Allele Frequencies at Cardiometabolic Risk Loci in an Uzbek Cohort from Tashkent: A Central Asian Reference and Priorities for Polygenic Score Validation. [PDF]

Genes (Basel)
Abdullaev AA, Zakirova DV, Kosushkin SA, Xonboev FZ, Abdullaeva GJ, Alieva RB, Turdikulova SU.   +6 more
europepmc   +1 more source

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Non-cognitive skills mediate education-related polygenic score associations with academic achievement across development. [PDF]

Nat Commun
Zhou Q, Liao W, Allegrini AG, Rimfeld K, Wertz J, Morris TT, Raffington L, Plomin R, Malanchini M.   +8 more
europepmc   +1 more source

Molecular, spatial, and AI‐enabled technologies for predicting neoadjuvant therapy response in locally advanced rectal cancer

The Journal of Pathology, EarlyView.
Abstract Pretreatment prediction of neoadjuvant response remains an unresolved challenge in locally advanced rectal cancer, where management is moving towards risk‐adapted and response‐oriented treatment strategies. Prediction remains difficult because response reflects interacting tumour‐intrinsic, immune, stromal, and spatial processes that are ...
Gina F Boot, Cibele Masotti, Claudia Corrò, Cédric Schraepen, Hannah L Williams, Thomas A Wright, Fiza Ishaqwala, Colin W Steele, Gertjan Rasschaert, Maxime W Lafarge, Enric Domingo, Inti Zlobec, Rodrigo Oliva Perez, Campbell SD Roxburgh, Timothy S Maughan, Sabine Tejpar, Thibaud Koessler, Viktor H Koelzer   +17 more
wiley   +1 more source

Transferability of polygenic risk score among diverse ancestries

Clinical and Translational Discovery, 2023
Xi Cheng, Sen Zhao
doaj   +1 more source