Results 151 to 160 of about 1,650,847 (244)

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Exploration of the causal relationship between inflammatory cytokines and type 2 diabetes via mendelian randomization and polygenic score. [PDF]

Front Immunol
Zhang C, Zhao Y, Pang H, Li N, Zheng H, Dong J, Liu Y, Li WT, Li H, Zhang N, Zhao M, Zhao L.   +11 more
europepmc   +1 more source

Genomic architecture and breeding trade‐offs of coconut drought tolerance

PLANTS, PEOPLE, PLANET, EarlyView.
The coconut palm is an extremely popular and economically important crop, with around 65 million tonnes produced in 2023. Although Africa's coconut sector is growing rapidly, it—and the livelihoods that depend on it—is threatened by climate change, particularly increased drought.
Theodore S. Brook, Tom Versluys, Bi Tra Serges Doubi, Sam Acors, Jahcub Trew, Kyle Macleod, Louis Bell‐Roberts, Katarina Piponi, Jean Louis Konan, Konan Engueran Djaha, Hala N'klo, Benjamin J. Roberts, Catherine M. Collins, Matteo Fumagalli, Julien Godwin, Vincent Savolainen   +15 more
wiley   +1 more source

Sex-specific impact of vitamin D and B9 concentrations on neuroticism: a polygenic score-based study. [PDF]

Front Psychiatry
Alfimova M, Golimbet V, Semina E, Chaika Y.   +3 more
europepmc   +1 more source

GenProb‐PCSM: A Simplified Weighted Germline Score for Prostate Cancer‐Specific Mortality

The Prostate, EarlyView.
ABSTRACT Background We previously developed a tier‐based germline classification using the National Comprehensive Cancer Network (NCCN)‐recommended DNA damage repair (DDR) genes and KLK3 I179T to predict prostate cancer (PCa)‐specific mortality (PCSM).
Jun Wei, Zhuqing Shi, Lucy Lu, John Wang, Julian Xu, Ashley J. Mulford, Huy Tran, Annabelle Ashworth, S. Lilly Zheng, Alan R. Sanders, William B. Issacs, Jun Luo, Brian Helfand, Jim Lu, Jianfeng Xu   +14 more
wiley   +1 more source

Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score. [PDF]

Diabetes
Deutsch AJ, Bell AS, Michalek DA, Burkholder AB, Nam S, Kreienkamp RJ, Sharp SA, Huerta-Chagoya A, Mandla R, Nanjala R, Luo Y, Oram RA, Florez JC, Onengut-Gumuscu S, Rich SS, Ng MCY, Motsinger-Reif AA, Manning AK, Mercader JM, Udler MS.   +19 more
europepmc   +1 more source

Identifying resistance‐conferring cytochrome P450s in weeds: experimental strategies and practical considerations

Pest Management Science, EarlyView.
Identifying resistance‐conferring cytochrome P450s requires integrating weed characterization, gene discovery and functional validation. No single approach is sufficient to distinguish causal resistance genes from herbicide‐metabolizing enzymes. Abstract Cytochrome P450 monooxygenases (P450s) play a pivotal role in metabolic herbicide resistance, yet ...
Satoshi Iwakami, Takuya Yamaguchi
wiley   +1 more source

The polygenic score for age at menopause is independently associated with the response of controlled ovarian hyperstimulation in women undergoing IVF. [PDF]

EBioMedicine
van Zwol-Janssens C, Lamballais S, Loehrer EA, Laven JSE, Kleefstra T, Louwers YV.   +5 more
europepmc   +1 more source

Characterization of Cry2Ab2 resistance in Crocidosema sp. (Lepidoptera: Tortricidae): resistance selection, inheritance, cross‐resistance patterns, and fitness costs

Pest Management Science, EarlyView.
This article reports the first characterization of Cry2Ab2 resistance in Crocidosema sp. Resistance appears to be autosomal and incompletely recessive, with a major‐gene contribution and potential involvement of additional genetic factors, and did not confer cross‐resistance to Cry1Ac or Cry1A.105. Abstract BACKGROUND The soybean bud borer, Crocidosema
Venicius E Pretto, Jéssica LS Grzybowski, Otavio Liberalesso, Daniela N Godoy, Arthur Dallanora, Marylia P Cargnin, Renato J Horikoshi, Sandy S Silva, Ramiro FL Ovejero, Leonardo Miraldo, Samuel Martinelli, Graham P Head, Oderlei Bernardi   +12 more
wiley   +1 more source

Genetic and Phenotypic Associations of the Polygenic Score of Delay Discounting and Life History Traits. [PDF]

Am J Hum Biol
Fieder M, Huber S.
europepmc   +1 more source