Results 171 to 180 of about 1,650,847 (244)

Whole exome sequencing and 12-SNP LDL polygenic score in South Indian patients with familial hypercholesterolemia. [PDF]

Sci Rep
Abraham N, P PV, Menon U, Bhavani N, Nair V, Futema M, Bhaskaran R, Menon R, Sekhar S, Krishnan S, Kumar H, Nair DR.   +11 more
europepmc   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

S4-multi: Enhancing polygenic score prediction in ancestrally diverse populations. [PDF]

HGG Adv
Baierl J, Tyrer JP, Lai PH, Gayther SA, Hsiao YW, Jones M, Pharoah PDP, Peng PC.   +7 more
europepmc   +1 more source

Chromatin Accessibility Profiling of the Canine Brain Reveals Regulatory Programs Associated With Dog‐Wolf Divergence and Human Psychiatric Risk

Integrative Zoology, EarlyView.
The dog is a valuable model for studying social behavior and neuropsychiatric disease. We generated an ATAC‐seq atlas of 7 brain regions and pituitary from 4 beagles, identifying 251,492 CREs. Integrating dog‐wolf divergence revealed tissue‐specific CREs overlapping divergent loci, including neuronal and neuroendocrine genes.
Biao Deng, Junze Wu, Ye Liu, Xuan Li, Yuanfang Xu, Rongjie Duan, Yibo Tong, Jinsheng Xu, Mengyang Ni, Zijie Scott Zhang, Dan Xue, Bowen Zhou, Yanhu Liu, Rui Cheng, Yuedong Zhang, Ya‐Ping Zhang   +15 more
wiley   +1 more source

Blood Pressure Polygenic Score Predicts Long-Term Blood Pressure Control and Treatment-Resistant Hypertension. [PDF]

Hypertension
Cho SMJ, Ruan Y, Lee HH, Koyama S, Juraschek SP, Allen NB, Yang E, McEvoy JW, Secemsky EA, Honigberg MC, Fahed AC, Patel AP, Hornsby WE, Natarajan P.   +13 more
europepmc   +1 more source

Joint associations of recovery capital and polygenic risk with electronic health record observed remission and relapse in substance use disorder: Longitudinal evidence from the All of Us research program

Addiction, EarlyView.
Abstract Background and aims Recovery capital and genetic liability may be related to substance use disorder (SUD) remission through psychosocial and biologic pathways, but their joint association with remission course remains poorly understood. This question is clinically important because people entering remission differ in recovery resources and ...
Janaka V. Kosgolla, Douglas C. Smith
wiley   +1 more source

Comprehensive benchmarking single and multi ancestry polygenic score methods with the PGS-hub platform. [PDF]

Nat Commun
Chen X, Wang F, Zhao H, Hao J, A Y, Yang X, Xu T, Zhou Y, Chen Q, Zhang R, Yu K, Zaib K, Fahed AC, Zhai G, Wang M.   +14 more
europepmc   +1 more source

Polygenic prediction of cannabis‐related outcomes: Evidence from the Avon Longitudinal Study of Parents and Children longitudinal cohort and the European gene–environment interaction case–control study

Addiction, EarlyView.
Abstract Background and aims Polygenic risk scores (PRSs) for cannabis use disorder (CUD), major depressive disorder (MDD), insomnia and chronic pain, and early age at cannabis initiation might be linked to problematic cannabis use. We tested whether: (1) higher PRS for CUD, MDD, insomnia and chronic pain are associated with earlier initiation and ...
Edoardo Spinazzola, Isabelle Austin‐Zimmerman, Giulia Trotta, Zhikun Li, Perry B. M. Leung, Edward Chesney, Qiang Li, Luis Alameda, Celso Arango, Michael O'Donovan, Jim van Os, Pak C. Sham, Craig Morgan, Evangelos Vassos, Diego Quattrone, Tom Freeman, Marta Di Forti, Robin M. Murray   +17 more
wiley   +1 more source

Polygenic Score Identifies Athletes at Increased Risk for Slower Recovery After Sport-Related Concussion: A Concussion Assessment, Research, and Education (CARE) Consortium Study. [PDF]

Sports Med
Zhang Z, Reiter JL, Nudelman KNH, Lai D, McAllister TW, McCrea MA, Broglio SP, Pasquina PF, Ren J, Liu Y, CARE Consortium Investigators.   +10 more
europepmc   +1 more source

Evaluation of Genetics in the Association Between Cardiorespiratory Fitness and Health: Insights from a Genome-Wide Polygenic Score for Cardiorespiratory Fitness in the FinnGen and HUNT cohorts. [PDF]

Scand J Med Sci Sports
Joensuu L, Lukander V, Herranen P, Tynkkynen NP, Kujala U, Lopéz-Bueno R, Nordeidet AN, Klevjer M, Øvretveit K, Wisløff U, Bye A, Ekelund U, Ollikainen M, FinnGen, Sillanpää E.   +14 more
europepmc   +1 more source