Results 241 to 250 of about 3,197,012 (359)

Neoplasm Polygenic Risk Score [PDF]

, 2020
openaire   +1 more source

Transferability of polygenic risk score among diverse ancestries

Clinical and Translational Discovery, 2023
Xi Cheng, Sen Zhao
doaj   +1 more source

Genetics of infertility and “assisted fertilization” in the Bible: The case of Abraham and his family

Andrology, EarlyView.
Abstract Couple infertility is a very ancient medical condition. One of the first descriptions of familial infertility/subfertility is contained in the first book of the Bible, Genesis, written in the 10th century BC and reporting tales from the oral tradition even occurred about 800 years earlier.
Manuela Simoni, Frank Tüttelmann, Livio Casarini   +2 more
wiley   +1 more source

Advances in the genetics of refractive errors: Contributions from the CREAM consortium

Acta Ophthalmologica, EarlyView.
Abstract The Consortium for Refractive Error and Myopia (CREAM) was established in 2011, bringing together an international team of researchers studying more than 30 cohorts. Since its establishment, CREAM has played a pivotal role in research investigating the genetics of myopia and other refractive errors, serving as a key driver of progress in the ...
Sze Wai Rosa Li, Xi He, Louise Terry, Virginie J. M. Verhoeven, Samantha Sze‐Yee Lee, Gareth Lingham, Jeremy A. Guggenheim, David A. Mackey, Seang‐Mei Saw, Caroline C. W. Klaver, Chi Pui Pang, CREAM Consortium   +11 more
wiley   +1 more source

Supplementary Figure S4 from Development of a breast cancer risk prediction model incorporating polygenic risk scores and non-genetic risk factors for Korean women

Jihye Choi, Tae-Woong Ha, Hye‐Mi Choi, Han‐Byoel Lee, Hee-Chul Shin, Woosung Chung, Wonshik Han   +6 more
openalex   +1 more source

Joint relative risks for estrogen receptor-positive breast cancer from a clinical model, polygenic risk score, and sex hormones

, 2017
Yiwey Shieh, Donglei Hu, Lin Ma, Scott Huntsman, Charlotte C. Gard, Jessica W. T. Leung, Jeffrey A. Tice, Elad Ziv, Karla Kerlikowske, Steven R. Cummings   +9 more
openalex   +2 more sources

The Alpha‐1 Pi*MZ Genotype Is an Independent Risk Factor for Hepatocellular Carcinoma Development in Patients With ACLD

Alimentary Pharmacology &Therapeutics, EarlyView.
Alpha‐1 antitrypsin deficiency is a genetic disease that affects the lungs and the liver. The role of the heterozygous genetic defect in the development of liver cancer in patients with cirrhosis is unclear. Our study found that carrying the Pi*MZ genotype increases the risk of developing liver cancer.
Lorenz Balcar, Georg Semmler, Bernhard Scheiner, Rafael Paternostro, Benedikt Simbrunner, Tina Jasmin Haunold, Mathias Jachs, Lukas Hartl, Benedikt Silvester Hofer, Nina Dominik, Michael Schwarz, Georg Kramer, Christian Sebesta, Paul Thöne, Matthias Pinter, Michael Trauner, Thomas Reiberger, Albert Friedrich Stättermayer, Mattias Mandorfer   +18 more
wiley   +1 more source

Statistical construction of calibrated prediction intervals for polygenic score-based phenotype prediction. [PDF]

Nat Genet
Xu C, Ganesh SK, Zhou X.
europepmc   +1 more source

Supplemental Table S8 from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage

Xiaosong Huang, Paul C. Lott, Donglei Hu, Valentina A. Zavala, Zoeb N. Jamal, Tatiana Vidaurre, Sandro Casavilca‐Zambrano, Jeannie Navarro Vásquez, Carlos A. Castañeda, Guillermo Valencia, Zaida Morante, Mónica Calderón, Julio E. Abugattas, Hugo Fuentes, Ruddy Liendo-Picoaga, José M. Cotrina, Silvia P. Neciosup, Patricia Rioja, Luis A. Salinas, Marco Gálvez-Niño, Scott Huntsman, Sixto E. Sánchez, Michelle A. Williams, Bizu Gelaye, Ana P. Estrada-Florez, Guadalupe Polanco‐Echeverry, Magdalena Echeverry, Alejandro Vélez Hoyos, Jenny A. Carmona-Valencia, Mábel Bohórquez, Javier Torres, Miguel Cruz, Weang-Kee Ho, Soo‐Hwang Teo, Mei-Chee Tai, Esther M. John, Christopher A. Haiman, David V. Conti, Fei Chen, Gabriela Torres-Mejı́a, Lawrence H. Kushi, Susan L. Neuhausen, Elad Ziv, Luis G. Carvajal‐Carmona, Laura Fejerman   +44 more
openalex   +1 more source

Existentialism and My ‘Postwolf’ Dachshund: Authenticity in the Age of Genetic Engineering

Bioethics, EarlyView.
ABSTRACT Human genetic engineering has the potential to profoundly alter the traits of future generations, raising critical ethical questions about authenticity and identity. Essentialist perspectives reject genetic engineering, claiming it inherently compromises authenticity by deviating from a species‐typical genome.
Donrich Thaldar
wiley   +1 more source