Results 251 to 260 of about 3,197,012 (359)

Validation of a genome-wide polygenic score for body mass index in South Asians. [PDF]

Front Genet
Menon R, Khan N, Charugulla S, Bassi A, Dangare P, Dedaniya A, Pant A, Anjanappa R, Samson PL, Satagopan U, Murugan S, Naikawadi A, Ramprasad VL, Gupta R.   +13 more
europepmc   +1 more source

Medical haematology: Repositioning haematology at the centre of medicine

British Journal of Haematology, EarlyView.
The complementary domains of Medical Haematology and Haemato‐Oncology share a biological framework. The left panel depicts red cells, platelets, coagulation, thrombosis and innate immunity, while the right panel shows lymphoid and myeloid malignancies.
Cheng Hock Toh, Imelda Bates, Sue Pavord
wiley   +1 more source

Evaluation of a Mitochondrial Polygenic Score for Parkinson's Disease Across Ancestries. [PDF]

Mov Disord
Ooi JCE, Tay YW, Tan AH, Lin CH, Brolin KA, Laabs BH, Sendel S, König IR, Caliebe A, Gabbert C, Andersh KM, Jones L, Lange LM, Fiske B, Sue C, Klein C, Trinh J, Lüth T, Global Parkinson's Genetics Program (GP2).   +18 more
europepmc   +1 more source

Late‐Holocene evolution of a small Sub‐Arctic glacier, Gljúfurárjökull (Tröllaskagi, northern Iceland)

Boreas, EarlyView.
Gljúfurárjökull, located on the Tröllaskagi Peninsula in northern Iceland, is a small glacier approximately 3.8 km in length. This study analyses the glacier's evolution through a combination of methods including: (i) geomorphological mapping, (ii) Cosmic‐Ray Exposure (CRE) dating, (iii) lichenometry and (iv) palaeoglacier reconstruction (volume ...
Nuria Andrés, José M. Fernández‐Fernández, David Palacios, Irene Schimmelpfennig, Leopoldo G. Sancho, Skafti Brynjólfsson, Þorsteinn Sæmundsson, Wesley R. Farnsworth, Luis M. Tanarro, Mariano Brito, Javier Santos‐González, Rosa B. González‐Gutiérrez, ASTER Team, Georges Aumaître, Karim Keddadouche   +14 more
wiley   +1 more source

Maternal parity modifies the association of birthweight polygenic score with fetal growth. [PDF]

Sci Rep
Wijesiriwardhana P, Habtewold TD, Wang G, Gleason JL, Wapner RJ, Grantz KL, Tekola-Ayele F.   +6 more
europepmc   +1 more source

Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians.

Journal of the American College of Cardiology, 2020
Minxian Wang, R. Menon, Sanghamitra Mishra, A. Patel, M. Chaffin, Deepak Tanneeru, Manjari Deshmukh, Oshin Mathew, Sanika Apte, Christina S Devanboo, Sumathi Sundaram, P. Lakshmipathy, S. Murugan, K. Sharma, K. Rajendran, S. Santhosh, R. Thachathodiyl, Hisham Ahamed, Aniketh Vijay Balegadde, T. Alexander, K. Swaminathan, R. Gupta, A. Mullasari, A. Sigamani, M. Kanchi, A. Peterson, A. Butterworth, J. Danesh, E. di Angelantonio, A. Naheed, M. Inouye, Rajiv Chowdhury, Ramprasad Vedam, S. Kathiresan, Ravi Gupta, A. Khera   +35 more
semanticscholar   +1 more source

The use of different types of networks, alone and in combination, for drug target identification

British Journal of Pharmacology, EarlyView.
Current therapeutic approaches often focus on targeting clinical symptoms or peripheral phenotypes rather than the underlying molecular mechanisms, or endophenotypes, that drive diseases. While symptom‐based drugs can alleviate discomfort, they do not necessarily alter disease progression and may overlook opportunities for prevention or early ...
Paolo Parini
wiley   +1 more source

PGSFusion streamlines polygenic score construction and epidemiological applications in biobank-scale cohorts. [PDF]

Genome Med
Yang S, Ye X, Ji X, Li Z, Tian M, Huang P, Cao C.   +6 more
europepmc   +1 more source

Breast cancer polygenic risk scores derived in White European populations are not calibrated for women of Ashkenazi Jewish descent

, 2023
Eleanor Roberts, Elke M. van Veen, Helen L. Byers, Ofra Barnett‐Griness, Naomi Gronich, Flavio Lejbkowicz, Mila Pinchev, Miriam J. Smith, Anthony Howell, William G. Newman, Emma R. Woodward, Elaine F. Harkness, Adam R. Brentnall, Jack Cuzick, Gad Rennert, Sacha J. Howell, D. Gareth Evans   +16 more
openalex   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source