Results 271 to 280 of about 40,214 (287)

Polygenic Risk Scores

Current Protocols, 2021
AbstractAs genome‐wide association studies have continued to identify loci associated with complex traits, the implications of and necessity for proper use of these findings, including prediction of disease risk, have become apparent. Many complex diseases have numerous associated loci with detectable effects implicating risk for or protection from ...
Michael D, Osterman, Tyler G, Kinzy, Jessica N Cooke, Bailey   +2 more
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Polygenic scores in biomedical research

Nature Reviews Genetics, 2022
Public health strategies aimed at disease prevention or early detection and intervention have the potential to advance human health worldwide. However, their success depends on the identification of risk factors that underlie disease burden in the general population.
Iftikhar J. Kullo, Cathryn M. Lewis, Michael Inouye, Alicia R. Martin, Samuli Ripatti, Nilanjan Chatterjee   +5 more
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Polygenic Risk Scores

2022
Coronary artery disease (CAD) is highly heritable. The technological advances over the past decade have enabled faster and more comprehensive genetic analysis with a simultaneous lowering of costs. This has resulted in a better understanding of the genetic determinants of atherosclerosis and CAD, and thus an increasing interest in and demand for ...
Christoffersen, Mette, Tybjærg-hansen, Anne   +1 more
openaire   +2 more sources

Boosting polygenic risk scores

2022
AbstractPolygenic risk scores (PRS) evaluate the individual genetic liability to a certain trait and are expected to play an increasingly important role in the field of clinical risk stratification. Most often, PRS are estimated based on summary statistics of univariate effects derived from genome-wide association studies.
Hannah Klinkhammer, Christian Staerk, Carlo Maj, Peter M. Krawitz, Andreas Mayr   +4 more
openaire   +1 more source

Polygene risk scores and randomized experiments

Behavioral and Brain Sciences, 2023
Abstract We explore Madole & Harden's (2022) suggestion that single-nucleotide polymorphism (SNP)/trait correlations are analogous to randomized experiments and thus can be given a causal interpretation.
Lauren N. Ross, Kenneth S. Kendler, James F. Woodward   +2 more
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Polygenic risk score in prostate cancer

Current Opinion in Urology, 2022
Purpose of review This study was conducted in order to review the outcomes regarding polygenic risk score (PRS) in prediction of prostate cancer (PCa). With the increasing proficiency of genetic analysis, assessment of PRS for prediction of PCa has been performed in numerous studies.
Jong Jin, Oh, Sung Kyu, Hong
openaire   +2 more sources

Multi-PGS enhances polygenic prediction: weighting 937 polygenic scores

2022
AbstractThe predictive performance of polygenic scores (PGS) is largely dependent on the number of samples available to train the PGS. Increasing the sample size for a specific phenotype is expensive and takes time, but this sample size can be effectively increased by using genetically correlated phenotypes. We propose a framework to generate multi-PGS
Clara Albiñana, Zhihong Zhu, Andrew J. Schork, Andrés Ingason, Hugues Aschard, Isabell Brikell, Cynthia M. Bulik, Liselotte V. Petersen, Esben Agerbo, Jakob Grove, Merete Nordentoft, David M. Hougaard, Thomas Werge, Anders D. Børglum, Preben Bo Mortensen, John J. McGrath, Benjamin M. Neale, Florian Privé, Bjarni J. Vilhjálmsson   +18 more
openaire   +1 more source

Polygenic Risk Scores in Human Disease

Clinical Chemistry
Abstract Background Polygenic risk scores (PRS) are measures of genetic susceptibility to human health traits. With the advent of large data repositories combining genetic data and phenotypic information, PRS are providing valuable insights into the genetic architecture of complex diseases and are ...
Dimitri J, Maamari, Roukoz, Abou-Karam, Akl C, Fahed   +2 more
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Polygenic risk scores in kidney transplantation

Current Opinion in Organ Transplantation
Purpose of review Estimation of genetic risk is crucial for understanding heritable diseases but also transplant outcomes. Polygenic risk scores (PRSs) are constructed from genome-wide association studies (GWAS) summing an individual's risk alleles weighted by their effect size.
Kira, Jelencsics, Rainer, Oberbauer
openaire   +2 more sources

Interpreting Alzheimer disease polygenic scores

Annals of Neurology, 2018
Chin Hong, Tan, Rahul S, Desikan
openaire   +2 more sources