Results 291 to 300 of about 2,929,620 (353)

Leveraging large-scale datasets and single cell omics data to develop a polygenic score for cisplatin-induced ototoxicity. [PDF]

Hum Genomics
Miao DNR, Wilke MAP, Pham J, Ladha F, Singh M, Arsenio J, Luca E, Dabdoub A, Yang W, Yang JJ, Drögemöller BI.   +10 more
europepmc   +1 more source

The DCIDE framework: systematic investigation of evolutionary hypotheses, exemplified with autism

Biological Reviews, EarlyView.
ABSTRACT Evolutionary explanations of mental disorders are a longstanding aim of evolutionary psychiatry, but have suffered from complexities including within‐disorder heterogeneity and environmental effects of contemporary societies obscuring possible ancestral functions.
Adam D. Hunt, Adrian V. Jaeggi
wiley   +1 more source

Associations between air pollution and surrounding greenness with internalizing and externalizing behaviors among schoolchildren

Child and Adolescent Mental Health, EarlyView.
Background Air pollution and greenness are emerging as modifiable risk and protective factors, respectively, in child psychopathology. However, research shows inconsistencies. Here, we examined associations between air pollution and surrounding greenness with internalizing and externalizing behaviors.
Uxue Zubizarreta‐Arruti, Rosa Bosch, María Soler Artigas, Judit Cabana‐Domínguez, Natalia Llonga, Pau Carabí‐Gassol, Valeria Macias‐Chimborazo, Laura Vilar‐Ribó, Josep Antoni Ramos‐Quiroga, Mireia Pagerols, Raquel Prat, Cristina Rivas, Èlia Pagespetit, Júlia Puigbó, Gemma Español‐Martín, Bruno Raimbault, Antonia Valentín, Jordi Sunyer, Maria Foraster, Mireia Gascón, Miquel Casas, Marta Ribasés, Silvia Alemany   +22 more
wiley   +1 more source

Decision letter: An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

, 2018

openalex   +1 more source

Expanding the Phenotypic Spectrum of SPG7 Rare Damaging Variants: Insights From a Hungarian Cohort

Clinical Genetics, EarlyView.
Rare damaging SPG7 variants were detected in 58 patients with spastic paraplegia, ataxia, mitochondrial dysfunction, or motoneuron lesions. The cumulative prevalence of SPG7‐related conditions in Hungary was estimated. Phenotypic spectra and mitochondrial dysfunction were assessed in monoallelic and biallelic cases, contributing to the understanding of
Idris Janos Jimoh, Peter Balicza, Tamas Szlepak, Dora Csaban, Aniko Gal, Adrienn Geresi, Zoltan Grosz, Agnes Palasti, Judit Boczan, Peter Klivenyi, Maria Judit Molnar   +10 more
wiley   +1 more source

Lipoprotein(a) Concentrations Are Independent of Polygenic Score for Coronary Artery Disease. [PDF]

JACC Adv
Trinh MN, Pournamdari A, Small AM, Peloso GM, Patel AP, Natarajan P.   +5 more
europepmc   +1 more source

Environmental Drivers of Malignant Clonal Selection in Precancerous Lesion Evolution

Cell Proliferation, EarlyView.
ABSTRACT Somatic mutations accumulation and subsequent malignant clonal selection are the processes that lead to cancer. The intricacy includes exposure to carcinogens as well as the ways in which these exposures interact with genetic, polygenic, or epigenetic predispositions.
Yancheng Lai, Shaosen Zhang
wiley   +1 more source

Polygenic score for educational attainment captures DNA variants shared between personality traits and educational achievement.

, 2019
Emily Smith‐Woolley, Saskia Selzam, Robert Plomin   +2 more
openalex   +1 more source

Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations. [PDF]

Psychol Med
Paul SE, Baranger DAA, Johnson EC, Jackson JJ, Gorelik AJ, Miller AP, Hatoum AS, Thompson WK, Strube M, Dick DM, Kamarajan C, Kramer JR, Plawecki MH, Chan G, Anokhin AP, Chorlian DB, Kinreich S, Meyers JL, Porjesz B, Edenberg HJ, Agrawal A, Bucholz KK, Bogdan R.   +22 more
europepmc   +1 more source

Alcohol Use Disorder Polygenic Score Compared With Family History and ADH1B.

JAMA Netw Open
Lai D, Zhang M, Abreu M, Schwantes-An TH, Chan G, Dick DM, Kamarajan C, Kuang W, Nurnberger JI, Plawecki MH, Rice J, Schuckit M, Porjesz B, Liu Y, Foroud T.   +14 more
europepmc   +1 more source